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846 research outcomes, page 4 of 85
  • publication . Conference object . Article . Preprint . 2018
    Open Access English
    Authors:
    Antelmi, Luigi; Ayache, Nicholas; Robert, Philippe; Lorenzi, Marco;
    Publisher: HAL CCSD
    Project: NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), CIHR

    Comment: accepted for presentation at MLCN 2018 workshop, in Conjunction with MICCAI 2018, September 20, Granada, Spain

  • publication . Article . 2015
    Open Access
    Authors:
    Henley, David B; Dowsett, Sherie A; Chen, Yun-Fei; Liu-Seifert, Hong; Grill, Joshua D; Doody, Rachelle S; Aisen, Paul; Raman, Rema; Miller, David S; Hake, Ann M; ...
    Publisher: Springer Nature
    Project: NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), NIH | A Phase 2 Trial of AAV-NG... (1R01AG030048-01A1), NIH | ALZHEIMERS DISEASE COOPER... (5U01AG010483-07), NIH | VITAMIN E TRIAL IN PERSON... (5R01AG016381-07)

    © 2015 Henley et al.; licensee BioMed Central. Introduction: To facilitate enrollment and meet local registration requirements, sponsors have increasingly implemented multi-national Alzheimer's disease (AD) studies. Geographic regions vary on many dimensions that may af...

  • publication . Article . 2013
    Open Access
    Authors:
    Tong, Tong; Wolz, Robin; Coupe, Pierrick; Hajnal, Joseph V.; Rueckert, Daniel;
    Publisher: Elsevier BV
    Project: NIH | Alzheimers Disease Neuroi... (1U01AG024904-01)

    International audience; We propose a novel method for the automatic segmentation of brain MRI images by using discriminative dictionary learning and sparse coding techniques. In the proposed method, dictionaries and classifiers are learned simultaneously from a set of b...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Callahan, Brandy L.; Ramirez, Joel; Berezuk, Courtney; Duchesne, Simon; Black, Sandra E.;
    Publisher: BioMed Central
    Project: CIHR , NIH | Alzheimers Disease Neuroi... (1U01AG024904-01)

    Introduction The definition of “objective cognitive impairment” in current criteria for mild cognitive impairment (MCI) varies considerably between research groups and clinics. This study aims to compare different methods of defining memory impairment to improve predict...

  • publication . Article . 2009
    Open Access English
    Authors:
    Paul S Aisen;
    Publisher: BioMed Central
    Project: NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), NIH | ALZHEIMERS DISEASE COOPER... (5U01AG010483-07)

    The field of Alzheimer's disease therapeutic research seems poised to bring to clinic the next generation of treatments, moving beyond symptomatic benefits to modification of the underlying neurobiology of the disease. But a series of recent trials has had disappointing...

  • publication . Preprint . Other literature type . 2018
    Open Access
    Authors:
    Rachmadi, Muhammad Febrian; Valdés-Hernández, Maria del C.; Li, Hongwei; Guerrero, Ricardo; Meijboom, Rozanna; Wiseman, Stewart; Waldman, Adam; Zhang, Jianguo; Rueckert, Daniel; Komura, Taku;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), CIHR

    <jats:title>Abstract</jats:title><jats:p>We present a complete study of limited one-time sampling irregularity map (LOTS-IM), a fully automatic unsupervised approach to extract brain tissue irregularities in magnetic resonance images (MRI), including its application and...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Sue Kulason; Daniel J. Tward; Timothy Brown; Chelsea S. Sicat; Chin-Fu Liu; J. Tilak Ratnanather; Laurent Younes; Arnold Bakker; Michela Gallagher; Marilyn Albert; ...
    Publisher: Elsevier
    Project: NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), NIH | Resource for Quantitative... (8P41EB015909-12), NIH | CRCNS US- German Res Prop... (5R01DC016784-02), CIHR , NIH | Neurodegenerative and Neu... (1R01EB020062-01A1), NIH | PHASE II/III trial for Sl... (5R01AG048349-02)

    Highlights • The transentorhinal cortex is significantly thinner in subjects with mild cognitive impairment than controls. • Mildly cognitively impaired subjects show a significantly greater atrophy rate in the transentorhinal cortex than controls.

  • publication . Article . 2018
    Open Access English
    Authors:
    Christian Ledig; Andreas Schuh; Ricardo Guerrero; Rolf A. Heckemann; Daniel Rueckert;
    Publisher: Nature Publishing Group
    Project: NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), CIHR , RCUK | Dementia Diagnosis: A too... (101685), EC | PREDICTND (611005)

    Abstract Magnetic resonance (MR) imaging is a powerful technique for non-invasive in-vivo imaging of the human brain. We employed a recently validated method for robust cross-sectional and longitudinal segmentation of MR brain images from the Alzheimer’s Disease Neuroim...

  • publication . Article . 2016
    Open Access English
    Authors:
    Nho, Kwangsik; Horgusluoglu, Emrin; Kim, Sungeun; Risacher, Shannon L.; Kim, Dokyoon; Foroud, Tatiana; Aisen, Paul S.; Petersen, Ronald C.; Jack, Clifford R.; Shaw, Leslie M.; ...
    Publisher: BioMed Central
    Project: CIHR , NIH | National Cell Repository ... (5U24AG021886-09), NIH | Integration of Bio-, Medi... (4R00LM011384-02), NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), NIH | CORE-- EDUCATION AND INFO... (5P30AG010133-08), NIH | Memory Circuitry in MCI a... (2R01AG019771-06), NIH | Indiana Clinical and Tran... (3UL1TR001108-02S1)

    Background: Pathogenic mutations in PSEN1 are known to cause familial early-onset Alzheimer’s disease (EOAD) but common variants in PSEN1 have not been found to strongly influence late-onset AD (LOAD). The association of rare variants in PSEN1 with LOAD-related endophen...

  • publication . Article . Other literature type . 2011
    Open Access English
    Authors:
    Casanova Ramon; Whitlow Christopher T.; Wagner Benjamin; Williamson Jeff; Shumaker Sally A.; Maldjian Joseph A.; Espeland Mark A.;
    Publisher: Frontiers Media S.A.
    Project: WT , NIH | Alzheimers Disease Neuroi... (1U01AG024904-01)

    In this work we use a large scale regularization approach based on penalized logistic regression to automatically classify structural MRI images (sMRI) according to cognitive status. Its performance is illustrated using sMRI data from the Alzheimer Disease Neuroimaging ...

846 research outcomes, page 4 of 85
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