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846 research outcomes, page 3 of 85
  • publication . Preprint . 2019
    Open Access English
    Authors:
    Llano, Daniel A.; Devanarayan, Priya; Devanarayan, Viswanath;
    Publisher: Cold Spring Harbor Laboratory
    Project: CIHR , NIH | Alzheimers Disease Neuroi... (1U01AG024904-01)

    Abstract Sensitive and accurate biomarkers for the prediction of conversion from mild cognitive impairment (MCI) to Alzheimer’s Disease (AD) are needed to both support clinical care and enhance clinical trial design. Here, we examined the potential of cerebrospinal flui...

  • publication . Article . 2015
    Open Access English
    Authors:
    Kim, J; Pan, W; Initi, ADN;
    Publisher: The Authors. Published by Elsevier Inc.
    Project: NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), NIH | Statistical Methods for G... (9R01GM113250-11A1), NIH | New Machine Learning Tool... (2R01GM081535-05), NIH | Genetic Association and P... (5R01HL105397-06), NIH | CORE-- CLINICAL (3P30AG010129-11S1), CIHR , NIH | "MR Morphometrics and Cog... (5K01AG030514-02), NIH | Association analysis of r... (5R01HL116720-05)

    Highlights • Rigorous testing for genuinely altered functional networks between two groups • The proposed tests are high powered and general across a wide range of scenarios. • Data-driven penalized network estimation • Data-driven choice between correlations and partia...

  • publication . Article . 2019
    Open Access English
    Authors:
    Franzmeier, Nicolai; Rubinski, Anna; Neitzel, Julia; Ewers, Michael; Alzheimer’s Disease Neuroimaging Initiative (ADNI);
    Publisher: Nature Publishing Group UK
    Project: CIHR , NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), EC | VASCAMY (334259)

    The single nucleotide polymorphism (SNP) rs744373 in the bridging integrator-1 gene (BIN1) is a risk factor for Alzheimer’s disease (AD). In the brain, BIN1 is involved in endocytosis and sustaining cytoskeleton integrity. Post-mortem and in vitro studies suggest that B...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Xiuchao Sui; Jagath C. Rajapakse;
    Publisher: Elsevier
    Project: NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), CIHR

    The clinical presentation of Alzheimer's disease (AD) is not unitary as heterogeneity exists in the disease's clinical and anatomical characteristics. MRI studies have revealed that heterogeneous gray matter atrophy patterns are associated with specific traits of cognit...

  • publication . Article . 2016
    Open Access English
    Authors:
    Maglietta R; Amoroso N; Boccardi M; Bruno S; Chincarini A; Gb, Frisoni; Paolo Inglese; Redolfi A; Tangaro S; Tateo A; ...
    Project: CIHR , NIH | Alzheimers Disease Neuroi... (1U01AG024904-01)

    The automated identification of brain structure in Magnetic Resonance Imaging is very important both in neuroscience research and as a possible clinical diagnostic tool. In this study, a novel strategy for fully automated hippocampal segmentation in MRI is presented. It...

  • publication . Preprint . 2018
    Open Access English
    Authors:
    Marinescu, Razvan V.; Oxtoby, Neil P.; Young, Alexandra L.; Bron, Esther E.; Toga, Arthur W.; Weiner, Michael W.; Barkhof, Frederik; Fox, Nick C.; Klein, Stefan; Alexander, Daniel C.; ...
    Project: EC | EuroPOND (666992), NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), RCUK | EPSRC Centre for Doctoral... (EP/L016478/1), EC | AMYPAD (115952)

    Comment: For more details on TADPOLE Challenge, see https://tadpole.grand-challenge.org/ This paper outlines the design of the TADPOLE Challenge. Paper contains 8 pages, 2 figures, 5 tables

  • publication . Article . Preprint . Other literature type . 2019
    Open Access English
    Authors:
    Paolo Avesani; Brent McPherson; Soichi Hayashi; Cesar F. Caiafa; Robert Henschel; Eleftherios Garyfallidis; Lindsey Kitchell; Daniel Bullock; Andrew Patterson; Emanuele Olivetti; ...
    Publisher: Nature Publishing Group
    Project: NIH | Administrative Core (5P30DK089503-04), NSF | NCS-FO: Connectome mappin... (1734853), NIH | Training in Clinical Tran... (5T32MH103213-04), NIH | Older Breast Cancer Patie... (5R01CA129769-09), NIH | Bioinformatics Strategies... (5R01LM011360-03), NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), NIH | Big Data for Discovery Sc... (3U54EB020406-03S1), NSF | BD Hubs: MIDWEST: SEEDCor... (1550320), NIH | Memory Circuitry in MCI a... (2R01AG019771-06), NIH | Center for Complexity and... (5P20NR015331-02),...

    We describe the Open Diffusion Data Derivatives (O3D) repository: an integrated collection of preserved brain data derivatives and processing pipelines, published together using a single digital-object-identifier. The data derivatives were generated using modern diffusi...

  • publication . Article . 2019
    Open Access
    Authors:
    Kai-Xin Dou; Can Zhang; Chen-Chen Tan; Wei Xu; Jie-Qiong Li; Xi-Peng Cao; Lan Tan; Jin-Tai Yu; null Alzheimer�s Disease Neuroimaging Initiative (ADNI);
    Publisher: Impact Journals, LLC
    Project: NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), CIHR

    Brain amyloid deposition is an early pathological event in Alzheimer’s disease (AD), and abnormally low levels amyloid-β42 peptide (Aβ42) in cerebrospinal fluid (CSF) can be detected in preclinical AD. To identify the genetic determinants that regulate the rate of CSF A...

  • publication . Conference object . Preprint . 2018
    Open Access
    Authors:
    Shi, Shan; Nathoo, Farouk;
    Publisher: IEEE
    Project: NSERC , NIH | Alzheimers Disease Neuroi... (1U01AG024904-01)

    Due to the rapid innovation of technology and the desire to find and employ biomarkers for neurodegenerative disease, high-dimensional data classification problems are routinely encountered in neuroimaging studies. To avoid over-fitting and to explore relationships betw...

  • publication . Article . 2013
    Open Access
    Authors:
    Niklas Mattsson; Philip Insel; Duygu Tosun; Jing Zhang; Clifford R Jack; Douglas Galasko; Michael Weiner; Alzheimer’s Disease Neuroimaging Initiative;
    Publisher: eScholarship, University of California
    Project: NIH | Brain Aging and Alzheimer... (2R01AG041851-06), NIH | Large Scale Biomarker Dis... (1U01NS082137-01), NIH | Stroke and Cognitive Impa... (5R01AG037551-03), NIH | "MR Morphometrics and Cog... (5K01AG030514-02), NIH | Pacific Northwest Udall C... (1P50NS062684-01A1), NIH | CLINICAL STUDIES OF NSAID... (2P01AG020206-06A1), NIH | CORE-- CLINICAL (3P30AG010129-11S1), NIH | ARIC Neurocognitive Study... (2U01HL096917-05), CIHR , NIH | Alzheimers Disease Neuroi... (1U01AG024904-01),...

    Background: Cerebrospinal fluid (CSF) α-synuclein is reduced in synucleinopathies, including dementia with Lewy bodies, and some studies have found increased CSF α-synuclein in Alzheimer's disease (AD). No study has explored effects of CSF α-synuclein on brain atrophy. ...

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