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449 research outcomes, page 2 of 45
  • publication . Article . 2009
    Open Access English
    Authors:
    Wei Guo; Chin-yuan Liang; Shili Lin;
    Publisher: Springer Nature
    Project: NIH | Genetic Analysis of Commo... (5R01GM031575-22), NIH | Statistical Methods for G... (5R01HG002657-03)

    <p>Abstract</p> <p>The Genetic Analysis Workshop 16 rheumatoid arthritis data include a set of 868 cases and 1194 controls genotyped at 545,080 single-nucleotide polymorphisms (SNPs) from the Illumina 550 k chip. We focus on investigating chromosomes 6 and 18, which hav...

  • publication . Article . 2005
    Open Access
    Authors:
    Bailey-Wilson, Joan E; Almasy, Laura; de Andrade, Mariza; Bailey, Julia; Bickeböller, Heike; Cordell, Heather J; Daw, E Warwick; Goldin, Lynn; Goode, Ellen L; Gray-McGuire, Courtney; ...
    Publisher: Springer Nature
    Project: NIH | Genetic Analysis of Commo... (5R01GM031575-22), NIH | GENOTYPING FOR LOCATING H... (N01HG065403-001), NIH | COLLABORATIVE STUDY ON TH... (5U10AA008403-15)

    ss Open Acce Introduction Genetic Analysis Workshop 14: microsatellite and single-nucleotide polymorphism marker loci for genome-wide scans Joan E Bailey-Wilson*1, Laura Almasy2, Mariza de Andrade3, Julia Bailey4, Heike Bickeboller5, Heather J Cordell6, E Warwick Daw7, ...

  • publication . Article . 2018
    Open Access English
    Authors:
    Biqi Wang; Anita L. DeStefano; Honghuang Lin;
    Publisher: BioMed Central
    Project: NIH | Genetic Analysis of Commo... (5R01GM031575-22)

    Epigenome-wide association studies (EWAS) have traditionally focused on the association test of single epigenetic markers with complex traits. However, it is possible that multiple cytosine-phosphate-guanine (CpG) sites at the same locus could jointly exert their effect...

  • publication . Article . 2011
    Open Access English
    Authors:
    Yan, Aimin; Laird, Nan M.; Li, Cheng;
    Publisher: BMC
    Project: NIH | dChip:Analysis and Visual... (3R01GM077122-02S1), NIH | Genetic Analysis of Commo... (5R01GM031575-22)

    <p>Abstract</p> <p>Recent advances in next-generation sequencing technologies have made it possible to generate large amounts of sequence data with rare variants in a cost-effective way. Statistical methods that test variants individually are underpowered to detect rare...

  • publication . Article . 2014
    Open Access English
    Authors:
    Wang S; Gao W; Ngwa J; Catherine Allard; Ct, Liu; La, Cupples;
    Publisher: Springer Nature
    Project: NIH | Genetic Analysis of Commo... (5R01GM031575-22), NIH | PHYSICAL EXAMINATION/TEST... (N01HC038038-029), NIH | Identifying variants caus... (5U01DK085545-02), NIH | GENETICS OF GALLBLADDER D... (5R01DK053889-04), NIH | Discovery of Functional V... (5U01DK085524-05), NIH | Multiethnic Study of Type... (5U01DK085526-05), NIH | Identifying T2D Variants ... (1U01DK085584-01), NIH | Identification and Replic... (5U01DK085501-02), NIH | NIDDM Susceptibility Gene... (5R01DK047482-13)

    In recent years, longitudinal family-based studies have had success in identifying genetic variants that influence complex traits in genome-wide association studies. In this paper, we suggest that longitudinal analyses may contain valuable information that can enable id...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Mariza de Andrade; E. Warwick Daw; Aldi T. Kraja; Virginia Fisher; Lan Wang; Ke Hu; Jing Li; Razvan Romanescu; Jenna Veenstra; Rui Sun; ...
    Publisher: BioMed Central
    Project: NIH | Genetic Analysis of Commo... (5R01GM031575-22)

    Background GAW20 working group 5 brought together researchers who contributed 7 papers with the aim of evaluating methods to detect genetic by epigenetic interactions. GAW20 distributed real data from the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study, ...

  • publication . Article . 2011
    Open Access English
    Authors:
    Mingxiang Teng; Yadong Wang; Guohua Wang; Jeesun Jung; Howard J Edenberg; Jeremy R Sanford; Yunlong Liu;
    Publisher: BMC
    Project: NIH | Data Management Core (5U10AA008401-27), NIH | Genetic Determinants of B... (3P01AG018397-10S1), NIH | Genetic Analysis of Commo... (5R01GM031575-22), NIH | Genomic analysis of RNA b... (5R01GM085121-02), NIH | Elucidating CIS-Acting El... (5R21AA017941-02)

    <p>Abstract</p> <p>Recent evidence suggests that many complex diseases are caused by genetic variations that play regulatory roles in controlling gene expression. Most genetic studies focus on nonsynonymous variations that can alter the amino acid composition of a prote...

  • publication . Article . 2009
    Open Access
    Authors:
    Wang, Minghui; Chen, Xiang; Zhang, Meizhuo; Zhu, Wensheng; Cho, Kelly; Zhang, Heping;
    Publisher: Springer Nature
    Project: NIH | Genetic Analysis of Commo... (5R01GM031575-22), NIH | Analysis of Genomic Data ... (5R01DA016750-07), NIH | Methodological Research o... (1K02DA017713-01), NIH | RESEARCH TRAINING IN MENT... (5T32MH014235-14)

    <p>Abstract</p> <p>Random forest is an efficient approach for investigating not only the effects of individual markers on a trait but also the effect of the interactions among the markers in genetic association studies. This approach is especially appealing for the anal...

  • publication . Article . 2009
    Open Access
    Authors:
    Pankratz Nathan D;
    Publisher: Springer Nature
    Project: NIH | Genetic Analysis of Commo... (5R01GM031575-22), NIH | Parkinson Disease Collabo... (2R01NS037167-06)

    <p>Abstract</p> <p>After performing a genome-wide association study, it is often difficult to know which regions to follow up, especially when no one marker reaches genome-wide significance. Researchers frequently focus on their top <it>N </it>findings, knowing that tru...

  • publication . Article . 2011
    Open Access English
    Authors:
    Joel B Fontanarosa; Yang Dai;
    Publisher: BMC
    Project: NIH | Genetic Analysis of Commo... (5R01GM031575-22)

    <p>Abstract</p> <p>We use least absolute shrinkage and selection operator (LASSO) regression to select genetic markers and phenotypic features that are most informative with respect to a trait of interest. We compare several strategies for applying LASSO methods in risk...

449 research outcomes, page 2 of 45
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