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449 research outcomes, page 2 of 45
  • publication . Article . 2016
    Open Access English
    Authors:
    Sha, Qiuying; Zhang, Kui; Zhang, Shuanglin;
    Publisher: Nature Publishing Group
    Project: NIH | Genetic Analysis of Commo... (5R01GM031575-22), NIH | QUANTITATIVE TRAIT LOCUS ... (5R01MH059490-02), NIH | Statistical Methods for R... (1R15HG008209-01A1), NIH | Next-Generation Bioinform... (1R01HG008115-01)

    Recently, there is increasing interest to detect associations between rare variants and complex traits. Rare variant association studies usually need large sample sizes due to the rarity of the variants, and large sample sizes typically require combining information fro...

  • publication . Article . 2009
    Open Access English
    Authors:
    D'Angelo Gina M; Rao DC; Gu C Charles;
    Publisher: Springer Nature
    Project: NIH | Genetic Analysis of Commo... (5R01GM031575-22), NIH | Washington University Ins... (3UL1RR024992-03S4)

    <p>Abstract</p> <p>Variable selection in genome-wide association studies can be a daunting task and statistically challenging because there are more variables than subjects. We propose an approach that uses principal-component analysis (PCA) and least absolute shrinkage...

  • publication . Article . 2014
    Open Access
    Authors:
    Mathew, George; George, Varghese; Xu, Hongyan;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Identifying T2D Variants ... (1U01DK085584-01), NIH | Identification and Replic... (5U01DK085501-02), NIH | Identifying variants caus... (5U01DK085545-02), NIH | GENETICS OF GALLBLADDER D... (5R01DK053889-04), NIH | Multiethnic Study of Type... (5U01DK085526-05), NIH | Genetic Analysis of Commo... (5R01GM031575-22), NIH | Discovery of Functional V... (5U01DK085524-05), NIH | NIDDM Susceptibility Gene... (5R01DK047482-13)

    Genome-wide association studies are very powerful in determining the genetic variants affecting complex diseases. Most of the available methods are very useful in detecting association between common variants and complex diseases. Recently, methods to detect rare varian...

  • publication . Article . 2009
    Open Access English
    Authors:
    Culverhouse Robert; Jin Wu; Jin Carol H; Hinrichs Anthony L; Suarez Brian K;
    Publisher: BioMed Central
    Project: NIH | GENETIC INTERACTIONS CONT... (1R03DA023166-01A1), NIH | Genetic Analysis of Commo... (5R01GM031575-22), NIH | Computational Methods to ... (5K25GM069590-03)

    <p>Abstract</p> <p>Many phenotypes of public health importance (e.g., diabetes, coronary artery disease, major depression, obesity, and addictions to alcohol and nicotine) involve complex pathways of action. Interactions between genetic variants or between genetic varia...

  • publication . Article . 2009
    Open Access
    Authors:
    Maren Vens; Arne Schillert; Inke R König; Andreas Ziegler;
    Publisher: Springer Nature
    Project: WT , NIH | Genetic Analysis of Commo... (5R01GM031575-22)

    <p>Abstract</p> <p>In genome-wide association studies, high-level statistical analyses rely on the validity of the called genotypes, and different genotype calling algorithms (GCAs) have been proposed. We compared the GCAs Bayesian robust linear modeling using Mahalanob...

  • publication . Article . 2014
    Open Access English
    Authors:
    Zhao Yang; Duncan C Thomas;
    Publisher: Springer Nature
    Project: NIH | GENETICS OF GALLBLADDER D... (5R01DK053889-04), NIH | Methods for Pathway Model... (5R01ES019876-02), NIH | Identifying variants caus... (5U01DK085545-02), NIH | Discovery of Functional V... (5U01DK085524-05), NIH | Design and Analysis of 2 ... (1U01HG005927-01), NIH | Genetic Analysis of Commo... (5R01GM031575-22), NIH | Identifying T2D Variants ... (1U01DK085584-01), NIH | Identification and Replic... (5U01DK085501-02), NIH | Multiethnic Study of Type... (5U01DK085526-05), NIH | NIDDM Susceptibility Gene... (5R01DK047482-13),...

    The cost of next-generation sequencing is now approaching that of the first generation of genome-wide single-nucleotide genotyping panels, but this is still out of reach for large-scale epidemiologic studies with tens of thousands of subjects. Furthermore, the anticipat...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Kang K. Yan; Hongyu Zhao; Herbert Pang;
    Publisher: BioMed Central
    Project: NIH | Characterization of Predi... (5P01CA154295-02), NIH | Identifying T2D Variants ... (1U01DK085584-01), NIH | Identification and Replic... (5U01DK085501-02), NIH | GWAS for Sleep Apnea and ... (1R01HL102830-01), NIH | Statistical Methods to Ma... (5R01GM059507-08), NIH | Genetics of Type 2 Diabet... (5R01DK073541-03), NIH | Identifying variants caus... (5U01DK085545-02), NIH | GENETICS OF GALLBLADDER D... (5R01DK053889-04), NIH | Discovery of Functional V... (5U01DK085524-05), NIH | Multiethnic Study of Type... (5U01DK085526-05),...

    Background High-throughput sequencing data are widely collected and analyzed in the study of complex diseases in quest of improving human health. Well-studied algorithms mostly deal with single data source, and cannot fully utilize the potential of these multi-omics dat...

  • publication . Article . 2003
    Open Access English
    Authors:
    Göring, Harald HH; Williams, Jeff T; Dyer, Thomas D; Blangero, John;
    Publisher: Springer Nature
    Project: NIH | Genetic Analysis of Commo... (5R01GM031575-22), NIH | QUANTITATIVE TRAIT LOCUS ... (5R01MH059490-02), NIH | CORE--FIELD AND CLINIC OP... (5P01HL045522-10), NIH | LIPID BIOCHEMISTRY--CORE (5P01HL028972-04)

    <p>Abstract</p> <p>An empirical comparison between three different methods for estimation of pair-wise identity-by-descent (IBD) sharing at marker loci was conducted in order to quantify the resulting differences in power and localization precision in variance component...

  • publication . Article . Other literature type . 2009
    Open Access English
    Authors:
    Tabangin, Meredith E; Woo, Jessica G; Martin, Lisa J;
    Publisher: Springer Nature
    Project: NIH | Genetic Analysis of Commo... (5R01GM031575-22)

    <p>Abstract</p> <p>Determining the most promising single-nucleotide polymorphisms (SNPs) presents a challenge in genome-wide association studies, when hundreds of thousands of association tests are conducted. The power to detect genetic effects is dependent on minor all...

  • publication . Article . 2014
    Open Access English
    Authors:
    Erin Austin; Wei Pan; Xiaotong Shen;
    Publisher: Springer Nature
    Project: NIH | Identifying T2D Variants ... (1U01DK085584-01), NIH | Identification and Replic... (5U01DK085501-02), NIH | Genetic Analysis of Commo... (5R01GM031575-22), NIH | Discovery of Functional V... (5U01DK085524-05), NIH | GENETICS OF GALLBLADDER D... (5R01DK053889-04), NIH | Identifying variants caus... (5U01DK085545-02), NIH | Statistical Methods for G... (5R01HL065462-06), NIH | Multiethnic Study of Type... (5U01DK085526-05), NIH | NIDDM Susceptibility Gene... (5R01DK047482-13), NIH | New Machine Learning Tool... (2R01GM081535-05),...

    Every known link between a genetic variant and blood pressure improves the understanding and potentially the risk assessment of related diseases such as hypertension. Genetic data have become increasingly comprehensive and available for an increasing number of samples. ...

449 research outcomes, page 2 of 45
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