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22 research outcomes, page 2 of 3
  • publication . Article . 2017
    Open Access
    Authors:
    Wenfu Ma; Elena Goldberg; Jonathan Goldberg; Jonathan Goldberg;
    Publisher: eLife Sciences Publications, Ltd
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | MOLECULAR GENETIC ANALYSI... (5F32GM012006-03)

    Native cargo proteins exit the endoplasmic reticulum (ER) in COPII-coated vesicles, whereas resident and misfolded proteins are substantially excluded from vesicles by a retention mechanism that remains unresolved. We probed the ER retention process using the proteostas...

  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Frederick C. Streich; Christopher D. Lima; Christopher D. Lima;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | Structural Studies of SUM... (5R01GM065872-12), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Structural studies of RNA... (1R35GM118080-01)

    Summary Post-translational protein modification by ubiquitin (Ub) and ubiquitin-like (Ubl) proteins such as small ubiquitin like modifier (SUMO) regulates processes including protein homeostasis, the DNA damage response, and the cell cycle. Proliferating cell nuclear an...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Michael G. Kharas; Fraser Glickman; Gerard Minuesa; Sun Mi Park; Carolina Adura; Saroj Gourkanti; Levi N. Naden; Christina S. Leslie; Steven K. Albanese; Wei Xie; ...
    Publisher: Nature Publishing Group
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Weill Cornell/Rockefeller... (5T32GM007739-30), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | Uncovering the role for M... (5R01DK101989-03), NIH | CANCER PHARMACOLOGY (5T32CA062948-09), NIH | The role of reorganizatio... (5R01GM121505-02), NIH | Upgrade of 800 MHz Spectr... (1S10OD016432-01A1), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Characterizing MSI2 in le... (5R01CA193842-02)

    The MUSASHI (MSI) family of RNA binding proteins (MSI1 and MSI2) contribute to a wide spectrum of cancers including acute myeloid leukemia. We find that the small molecule Ro 08–2750 (Ro) binds directly and selectively to MSI2 and competes for its RNA binding in biochem...

  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Zhong Deng; Hongda Huang; Paul M. Lieberman; Fang Lu; Andreas Wiedmer; Dinshaw J. Patel; Olga Vladimirova;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | CONSOLIDATED BASIC CANCER... (5P30CA010815-28), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Chromatin Regulation of K... (1P01CA174439-01A1)

    The histone H3.3 chaperone DAXX is implicated in formation of heterochromatin and transcription silencing, especially for newly infecting DNA virus genomes entering the nucleus. Epstein-Barr virus (EBV) can efficiently establish stable latent infection as a chromatinize...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Dinshaw J. Patel; Jennifer Gebetsberger; Aiming Ren; Aiming Ren; Michael Andreas Juen; Christoph Kreutz; Ronald Micura; Nikola Vušurović; Pu Gao;
    Project: FWF | Chemical synthesis of mod... (P 27947), NIH | Biochemical and structura... (5U19CA179564-02), NIH | NE-CAT Center for Advance... (4P41GM103403-14), FWF | Single-molecule FRET inve... (I 1040), FWF | Seeing the invisible &#x9... (P 28725), SNSF | Exploring the function an... (P2BEP3_162061), FWF | Resolving excited states ... (P 26550), NIH | MOUSE GENETICS (2P30CA008748-43)

    The field of small self-cleaving nucleolytic ribozymes has been invigorated by the recent discovery of the twister, twister-sister, pistol and hatchet ribozymes. We report the crystal structure of a pistol ribozyme termed env25, which adopts a compact tertiary architect...

  • publication . Article . 2018
    Open Access English
    Authors:
    Garg, Angad; Goldgur, Yehuda; Schwer, Beate; Shuman, Stewart;
    Publisher: Oxford University Press
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | mRNA Capping Enzyme (2R01GM052470-09), NIH | Mechanisms of DNA and RNA... (1R35GM126945-01)

    Abstract Pho7, a member of the Zn2Cys6 family of fungal transcription factors, is the key transcriptional activator underlying fission yeast phosphate homeostasis, a physiological response to phosphate starvation in which the pho1, pho84 and tgp1 genes are upregulated. ...

  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Hongda Huang; Hongda Huang; Aayushi Y Jain; Dinshaw J. Patel; Dominik Hoelper; Peter W. Lewis;
    Publisher: Springer Nature
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | MOUSE GENETICS (2P30CA008748-43)

    The ATRX-DAXX histone chaperone complex incorporates H3.3 in heterochromatin in a replication-independent manner. Here, the authors present a high-resolution x-ray crystal structure of an interaction surface between ATRX and DAXX, and characterize ATRX-dependent and-ind...

  • publication . Article . 2020
    Open Access English
    Authors:
    Shreya Ghosh; Yehuda Goldgur; Stewart Shuman;
    Publisher: Oxford University Press
    Project: NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanisms of DNA and RNA... (1R35GM126945-01), NIH | DNA Ligases in Mycobacter... (5R01AI064693-03)

    <jats:title>Abstract</jats:title> <jats:p>Mycobacterial Pol1 is a bifunctional enzyme composed of an N-terminal DNA flap endonuclease/5′ exonuclease domain (FEN/EXO) and a C-terminal DNA polymerase domain (POL). Here we document additional functions of Pol1: FEN activit...

  • publication . Article . Other literature type . 2018
    Open Access
    Authors:
    Akiko Koide; Stephen B. Long; Shohei Koide; Leanne Pedi; Melinda M. Diver;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | Bridge 1: Conformational ... (2U54GM087519-06), NIH | MOLECULAR GENETIC ANALYSI... (5F32GM012006-03), NIH | MOUSE GENETICS (2P30CA008748-43)

    The X-ray structure of the integral membrane protein isoprenylcysteine carboxyl methyltransferase suggests mechanisms by which it recognizes both water-soluble and membrane-bound reactants to catalyze the methylation of RAS and other CAAX proteins at the membrane-cytoso...

  • publication . Article . 2019
    Open Access English
    Authors:
    Hann, Zachary S.; Metzger, Meredith B.; Weissman, Allan M.; Lima, Christopher D.;
    Publisher: International Union of Crystallography
    Project: NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | Structural and Functional... (5R01GM079196-07), NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Structural studies of RNA... (1R35GM118080-01)

    A 1.7 Å resolution co-crystal structure of U7BR from Schizosaccharomyces pombe in complex with Ubc7 is reported. Structural comparisons and biochemistry suggest that U7BR presents a steric impediment to E1 binding and inhibits E1-mediated charging, respectively.

22 research outcomes, page 2 of 3