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57,352 research outcomes, page 2 of 5,736
  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Mark D. A. Cooper; Cristian Estop-Aragonés; James P. Fisher; Aaron Thierry; Mark H. Garnett; Dan J. Charman; Julian B. Murton; Gareth K. Phoenix; Rachael Treharne; Steve V. Kokelj; ...
    Publisher: Nature Publishing Group
    Project: RCUK | CYCLOPS: Carbon Cycling L... (NE/K00025X/1), RCUK | Carbon Cycling Linkages o... (NE/K000292/1), RCUK | CYCLOPS: Carbon Cycling L... (NE/K000179/1)

    Models predict that thaw of permafrost soils at northern high latitudes will release tens of billions of tonnes of carbon (C) to the atmosphere by 2100 (refs 1,2,3). The effect on the Earth’s climate depends strongly on the proportion of this C that is released as the m...

  • publication . Article . 2014
    Open Access
    Authors:
    Fernandez, Israel S.; Bai, Xiao-Chen; Murshudov, Garib; Scheres, Sjors H. W.; Ramakrishnan, V.;
    Publisher: Elsevier BV
    Project: RCUK | Visualising proteins in h... (MC_UP_A025_1013), WT | Structure and function of... (096570), RCUK | Structure and function of... (MC_U105184332)

    Summary The cricket paralysis virus internal ribosome entry site (CrPV-IRES) is a folded structure in a viral mRNA that allows initiation of translation in the absence of any host initiation factors. By using recent advances in single-particle electron cryomicroscopy, w...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Kirschner, K; Chandra, T; Kiselev, V; Flores-Santa Cruz, D; Macaulay, IC; Park, HJ; Li, Juan; Kent, David; Kumar, R; Pask, DC; ...
    Project: WT | Epigenetic reprogramming ... (095645), WT | CALR mutations and human ... (104710), RCUK | Adaptation of a high reso... (BB/K010867/1)

    Kirschner et al. describe heterogeneous aging of hematopoietic stem cells (HSCs), with a subset of old HSCs displaying signs of functional exhaustion. An increase in proliferation expands the aged HSC subgroup, linking prolonged proliferation to functional decline in HS...

  • publication . Article . Other literature type . 2019
    Open Access
    Authors:
    Macreadie, Peter I.; Anton, Andrea; Raven, John A.; Beaumont, Nicola; Connolly, Rod M.; Friess, Daniel A.; Kelleway, Jeffrey J.; Kennedy, Hilary; Kuwae, Tomohiro; Lavery, Paul S.; ...
    Publisher: Springer Science and Business Media LLC
    Project: ARC | Discovery Early Career Re... (DE170101524), ARC | Linkage Projects - Grant ... (LP160100242), NSF | LTER: FCE III - Coastal O... (1237517), RCUK | CoastWEB: Valuing the con... (NE/N013573/1), ARC | Discovery Projects - Gran... (DP160100248), RCUK | Extreme Climatic Events i... (NE/K008439/1), NSF | LTREB Renewal: Twenty-thr... (1457100), ARC | Linkage Projects - Grant ... (LP150100519), NSF | LTREB: Twenty-three years... (0950080), ARC | Linkage Infrastructure, E... (LE170100219)

    P.I.M. and C.E.L. were supported by an Australian Research Council Linkage Project (LP160100242). C.M.D. was supported by baseline funding from King Abdullah University of Science and Technology. T.K. and K.W. were supported by JSPS KAKENHI (18H04156) and the Environmen...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Ricci, Cristian; Wood, Angela; Muller, David; Gunter, Marc J; Agudo, Antonio; Boeing, Heiner; Van Der Schouw, Yvonne T; Warnakula, Samantha; Saieva, Calogero; Spijkerman, Annemieke; ...
    Project: RCUK | Large-scale integrative s... (MR/L003120/1), EC | EPICHEART (268834), RCUK | Aetiology of type 2 diabe... (MC_UU_12015/1), RCUK | Nutritional epidemiology (MC_UU_12015/5), EC | EPIC-CVD (279233), RCUK | Study of the interplay of... (G0800270)

    ABSTRACT Objective To investigate the association between alcohol consumption (at baseline and over lifetime) and non-fatal and fatal coronary heart disease (CHD) and stroke. Design Multicentre case-cohort study. Setting A study of cardiovascular disease (CVD) aetiology...

  • publication . Article . 2009
    Open Access
    Authors:
    Ghafari, Homanaz; Zhou, Yanzhou; Ali, Selman; Hanley, Quentin S.;
    Publisher: SPIE-Intl Soc Optical Eng
    Project: RCUK | Imaging fluorescence from... (EP/E013422/1)

    Optically sectioned detection of fluorescence immunoassays using a confocal microscope enables the creation of both homo- and heterogeneous planar format assays. We report a set assays requiring optically sectioned detection using a model system and analysis procedures ...

  • publication . Article . 2015
    Open Access
    Authors:
    Lopez, Felipe L; Ernest, Terry B; Tuleu, Catherine; Gul, Mine Orlu;
    Publisher: Informa Healthcare
    Project: RCUK | From Targeted Therapeutic... (EP/I01375X/1)

    Introduction: Most conventional drug delivery systems are not acceptable for pediatric patients as they differ in their developmental status and dosing requirements from other subsets of the population. Technology platforms are required to aid the development of age-app...

  • publication . Article . 2015
    Open Access English
    Authors:
    Philip Browne;
    Publisher: The Authors. Published by Elsevier Ltd.
    Project: RCUK | Climate Model Initializat... (NE/J005878/1)

    This paper details a strategy for modifying the source code of a complex model so that the model may be used in a data assimilation context, and gives the standards for implementing a data assimilation code to use such a model. The strategy relies on keeping the model s...

  • publication . Article . Other literature type . Preprint . 2019
    Open Access
    Authors:
    Elizabeth Buckingham-Jeffery; Edward M. Hill; Samik Datta; Erin Dilger; Orin Courtenay;
    Publisher: Springer Science and Business Media LLC
    Project: RCUK | MidPlus: A Centre of Exce... (EP/K000128/1), WT | Field trials of synthetic... (091689)

    <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>The parasite <jats:italic>Leishmania infantum</jats:italic> causes zoonotic visceral leishmaniasis (VL), a potentially fatal vector-borne disease of canids and humans. Zoonotic VL pose...

  • publication . Preprint . Article . 2020
    Open Access English
    Authors:
    A S Binks; R D Jeffries; N J Wright;
    Project: RCUK | ASTThe Formation and Dyna... (ST/M005569/1)

    In the last three decades several hundred nearby members of young stellar moving groups (MGs) have been identified, but there has been less systematic effort to quantify or characterise young stars that do not belong to previously identified MGs. Using a kinematically u...

57,352 research outcomes, page 2 of 5,736
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