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73 research outcomes, page 1 of 8
  • publication . Article . 2019
    Open Access English
    Authors:
    Koen H. G. Verschueren; Clement Blanchet; Jan Felix; Ann Dansercoer; Dirk De Vos; Yehudi Bloch; Jozef Van Beeumen; Dmitri Svergun; Irina Gutsche; Savvas N. Savvides; ...
    Publisher: HAL CCSD
    Project: EC | iNEXT (653706), EC | Chap4Resp (647784), EC | CALIPSOplus (730872)

    Abstract: Across different kingdoms of life, ATP citrate lyase (ACLY, also known as ACL) catalyses the ATP-dependent and coenzyme A (CoA)-dependent conversion of citrate, a metabolic product of the Krebs cycle, to oxaloacetate and the high-energy biosynthetic precursor ...

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  • publication . Article . 2017
    Open Access English
    Authors:
    J. Retel; Andrew J. Nieuwkoop; Matthias Hiller; Victoria A. Higman; Emeline Barbet-Massin; Jan Stanek; Loren B. Andreas; W. Trent Franks; Barth-Jan van Rossum; Kutti R. Vinothkumar; ...
    Publisher: HAL CCSD
    Project: EC | iNEXT (653706), EC | BIO-NMR (261863)

    β-barrel proteins mediate nutrient uptake in bacteria and serve vital functions in cell signaling and adhesion. For the 14-strand outer membrane protein G of Escherichia coli, opening and closing is pH-dependent. Different roles of the extracellular loops in this proces...

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  • publication . Article . 2019
    Open Access English
    Authors:
    Alessandro Pagliuso; To Nam Tham; Eric Allemand; Stevens Robertin; Bruno Dupuy; Quentin Bertrand; Christophe Bécavin; Mikael Koutero; Valérie Najburg; Marie-Anne Nahori; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | BacCellEpi (670823), ANR | CBH-EUR-GS (ANR-17-EURE-0003)

    Summary RNA-binding proteins (RBPs) perform key cellular activities by controlling the function of bound RNAs. The widely held assumption that RBPs are strictly intracellular has been challenged by the discovery of secreted RBPs. However, extracellular RBPs have been de...

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  • publication . Article . 2016
    Open Access English
    Authors:
    Eaazhisai Kandiah; Diego Carriel; Julien Pérard; Hélène Malet; Maria Bacia; K. Liu; Sze W. S. Chan; Walid A. Houry; Sandrine Ollagnier de Choudens; Sylvie Elsen; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: CIHR , ANR | acidstress (ANR-12-JSV8-0002), NSERC , EC | Chap4Resp (647784), ANR | ARCANE (ANR-11-LABX-0003)

    International audience; The inducible lysine decarboxylase LdcI is an important enterobacterial acid stress response enzyme whereas LdcC is its close paralogue thought to play mainly a metabolic role. A unique macromolecular cage formed by two decamers of the Escherichi...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Yoann Millerioux; Muriel Mazet; Guillaume Bouyssou; Stefan Allmann; Tiila Riikka Kiema; Eloïse Bertiaux; Laetitia Fouillen; Chandan J. Thapa; Marc Biran; Nicolas Plazolles; ...
    Persistent Identifiers
    Project: EC | PARAMET (290080), ANR | GLYCONOV (ANR-15-CE15-0025), ANR | ParaFrap (ANR-11-LABX-0024)

    Author summary In this study, we have (i) determined the carbon sources used by the Trypanosoma brucei procyclic insect form to feed the essential lipid biosynthetic pathways, (ii) further characterized the metabolic pathways leading to their degradation into acetyl-CoA...

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  • publication . Article . 2017
    Open Access English
    Authors:
    Igor Orlov; Alexander G. Myasnikov; Leonid Andronov; S. Kundhavai Natchiar; Heena Khatter; Brice Beinsteiner; Jean-François Ménétret; Isabelle Hazemann; Kareem Mohideen; Karima Tazibt; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | TRANSLATIONMACHINERY (243296)

    International audience; After gradually moving away from preparation methods prone to artefacts such as plastic embedding and negative staining for cell sections and single particles, the field of cryo electron microscopy (cryo-EM) is now heading off at unprecedented sp...

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  • publication . Article . 2019
    Open Access English
    Authors:
    Carolina Megumi Mizuno; Bina Prajapati; Soizick Lucas-Staat; Télesphore Sime-Ngando; Patrik Forterre; Dennis H. Bamford; David Prangishvili; Mart Krupovic; Hanna M. Oksanen;
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | EVOMOBIL (340440), EC | LTFCOFUND2013 (609409), ANR | ENVIRA (ANR-17-CE15-0005)

    International audience; The diversity of archaeal viruses is severely undersampled compared with that of viruses infecting bacteria and eukaryotes, limiting our understanding on their evolution and environmental impacts. Here, we describe the isolation and characterizat...

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  • publication . Article . Other literature type . 2020
    Open Access English
    Authors:
    Nicolas Flaugnatti; Chiara Rapisarda; Martial Rey; Solène G Beauvois; Viet Anh Nguyen; Stéphane Canaan; Eric Durand; Julia Chamot-Rooke; Eric Cascales; Rémi Fronzes; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | iNEXT (653706)

    International audience; The bacterial type VI secretion system (T6SS) is a macromolecular machine that injects effectors into prokaryotic and eukaryotic cells. The mode of action of the T6SS is similar to contractile phages: the contraction of a sheath structure pushes ...

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  • publication . Article . 2017
    Open Access English
    Authors:
    Céline Amadori; Yme U. van der Velden; Damien Bonnard; Igor Orlov; Nikki van Bel; Erwann Le Rouzic; Laia Miralles; Julie Brias; Francis Chevreuil; Danièle Spehner; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | HIVINNOV (305137)

    Background HIV-1 Integrase (IN) interacts with the cellular co-factor LEDGF/p75 and tethers the HIV preintegration complex to the host genome enabling integration. Recently a new class of IN inhibitors was described, the IN-LEDGF allosteric inhibitors (INLAIs). Designed...

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  • publication . Report . 2019
    English
    Authors:
    Raciti, Marco; Moranville, Yoann; Thiel, Carsten;
    Publisher: HAL CCSD
    Project: EC | DESIR (731081)
73 research outcomes, page 1 of 8