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90 research outcomes, page 1 of 9
  • publication . Article . 2017
    Open Access English
    Authors:
    Rasa Sukackaite; Daniela Cornacchia; Malene Ringkjøbing Jensen; Philippe J. Mas; Martin Blackledge; Elin Enervald; Guangyou Duan; Tania Auchynnikava; Maja Köhn; Darren J. Hart; ...
    Publisher: HAL CCSD
    Project: WT | How centromeres are speci... (095021), WT | Core funding renewal for ... (092076), EC | EIPOD (229597)

    International audience; Rif1 is a conserved protein that plays essential roles in orchestrating DNA replication timing, controlling nuclear architecture, telomere length and DNA repair. However, the relationship between these different roles, as well as the molecular ba...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Erika Pellegrini; Ambroise Desfosses; Arndt Wallmann; Wiebke Manuela Schulze; Kristina Rehbein; Philippe Mas; Luca Signor; Stephanie Gaudon; Grasilda Zenkeviciute; Michael Hons; ...
    Persistent Identifiers

    Activation of the innate immune pattern recognition receptor NOD2 by the bacterial muramyl-dipeptide peptidoglycan fragment triggers recruitment of the downstream adaptor kinase RIP2, eventually leading to NF-κB activation and proinflammatory cytokine production. Here w...

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  • publication . Article . 2016
    Open Access English
    Authors:
    Orla M. Dunne; M. Weidenhaupt; P. Callow; A. Martel; Martine Moulin; Stephen J. Perkins; Michael Haertlein; V.T. Forsyth;
    Persistent Identifiers
    Publisher: Springer Berlin Heidelberg
    Project: UKRI | Deuteration Initiative fo... (EP/C015452/1)

    Small-angle neutron scattering (SANS) is a powerful technique for the characterisation of macromolecular structures and interactions. Its main advantage over other solution state approaches is the ability to use D2O/H2O solvent contrast variation to selectively match ou...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Patricia Pereira Aguilar; Katrin Reiter; Viktoria Wetter; Petra Steppert; Daniel Maresch; Wai Li Ling; Peter Satzer; Alois Jungbauer;
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: FWF | Biomolecular Technology o... (W 1224)

    International audience; Downstream processing (DSP) of large bionanoparticles is still a challenge. The present study aims to systematically compare some of the most commonly used DSP strategies for capture and purification of enveloped viruses and virus-like particles ...

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  • publication . Article . 2015
    Open Access English
    Authors:
    Jacomin, Anne-Claire; Bescond, Amandine; Soleilhac, Emmanuelle; Gallet, Benoit; Schoehn, Guy; Fauvarque, Marie-Odile; Taillebourg, Emmanuel; Srinivasula, Srinivasa;
    Persistent Identifiers
    Publisher: Public Library of Science

    International audience; Autophagy is a catabolic process that delivers cytoplasmic components to the lysosomes. Protein modification by ubiquitination is involved in this pathway: it regulates the stability of autophagy regulators such as BECLIN-1 and it also functions ...

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  • publication . Article . 2015
    Open Access English
    Authors:
    Stéphanie Thébault; Morgane Agez; Xiaoke Chi; Johann Stojko; Vincent Cura; Stephanie B. Telerman; Laurent Maillet; Fabien Gautier; Isabelle Billas-Massobrio; Catherine Birck; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: ANR | INRT (ANR-10-LABX-0030), CIHR , ANR | UNISTRA (ANR-10-IDEX-0002)

    International audience; Translationally Controlled Tumor Protein (TCTP) is anti-apoptotic, key in development and cancer, however without the typical Bcl2 family members' structure. Here we report that TCTP contains a BH3-like domain and forms heterocomplexes with Bcl-x...

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  • publication . Article . 2015
    Open Access English
    Authors:
    Simon Ladevèze; Gianluca Cioci; Pierre Roblin; Lionel Mourey; Samuel Tranier; Gabrielle Potocki-Veronese;
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | BIOSTRUCT-X (283570)

    Crystal structures of the GH130 enzyme Uhgb_MP in the apo form and in complex with mannose and N-acetylglucosamine are described and the structural determinants of the functional specificities of the enzymes involved in N-glycan breakdown by human gut bacteria are ident...

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  • publication . Article . 2012
    Open Access English
    Authors:
    Tsjerk A. Wassenaar; Marc van Dijk; Nuno Loureiro-Ferreira; Gijs van der Schot; Sjoerd J. Vries; Christophe Schmitz; Johan van der Zwan; Rolf Boelens; Andrea Giachetti; Lucio Ferella; ...
    Project: EC | WENMR (261572), FCT | GRID/GRI/81809/2006 (81809), EC | E-NMR (213010)

    International audience; The WeNMR (http://www.wenmr.eu) project is a European Union funded international effort to streamline and automate analysis of Nuclear Magnetic Resonance (NMR) and Small Angle X-Ray scattering (SAXS) imaging data for atomic and near-atomic resolu...

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  • publication . Article . 2016
    Open Access English
    Authors:
    Izhar Burhan; Giulia Furini; Hugues Lortat-Jacob; Adeola G. Atobatele; Alessandra Scarpellini; Nina Schroeder; John M. Atkinson; M. Maamra; Faith Nutter; Philip F. Watson; ...
    Persistent Identifiers
    Publisher: Nature Publishing Group
    Project: WT | Does Syndecan-4 play a cr... (087163)

    Transglutaminase-2 (TG2) is a new anti-fibrotic target for chronic kidney disease, for its role in altering\ud the extracellular homeostatic balance leading to excessive build-up of matrix in kidney. However,\ud there is no confirmation that TG2 is the only transglutami...

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  • publication . Article . 2014
    English
    Authors:
    Ma, Peixiang; Haller, Jens,; Zajakala, Jérémy; Macek, Pavel; Sivertsen, Astrid C.; Willbold, Dieter; Boisbouvier, Jérôme; Schanda, Paul;
    Publisher: HAL CCSD
    Project: EC | PROTDYN2FUNCTION (311318)

    International audience; Solution-state NMR spectroscopic techniques, and in par-ticular so-called relaxation-dispersion (RD) NMR approaches, have proven very successful for studying ms–ms motion and characterizing the exchanging short-lived con-formations. [1] RD NMR te...

90 research outcomes, page 1 of 9