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99 research outcomes, page 1 of 10
  • publication . Article . 2016
    Open Access
    Authors:
    Ai Woon Yee; Martine Moulin; Nina Breteau; Michael Haertlein; Edward P. Mitchell; Jonathan B. Cooper; Elisabetta Boeri Erba; V. Trevor Forsyth;
    Publisher: Wiley
    Project: UKRI | Deuteration Initiative fo... (EP/C015452/1)

    Abstract It is well established that the formation of transthyretin (TTR) amyloid fibrils is linked to the destabilization and dissociation of its tetrameric structure into insoluble aggregates. Isotope labeling is used for the study of TTR by NMR, neutron diffraction, ...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Christine Orengo; Sameer Velankar; Shoshana Wodak; Vincent Zoete; Alexandre M.J.J. Bonvin; Arne Elofsson; K. Anton Feenstra; Dietland L. Gerloff; Thomas Hamelryck; John M. Hancock; ...
    Publisher: HAL CCSD
    Project: EC | BioExcel-2 (823830)

    Structural bioinformatics provides the scientific methods and tools to analyse, archive, validate, and present the biomolecular structure data generated by the structural biology community. It also provides an important link with the genomics community, as structural bi...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Conrad V. Simoben; Dina Robaa; Alokta Chakrabarti; Karin Schmidtkunz; Martin Marek; Julien Lancelot; Srinivasaraghavan Kannan; Jelena Melesina; Tajith B. Shaik; Raymond J. Pierce; ...
    Persistent Identifiers
    Publisher: MDPI
    Project: EC | SETTREND (241865), EC | A-PARADDISE (602080)

    International audience; A promising means in the search of new small molecules for the treatment of schistosomiasis (amongst other parasitic ailments) is by targeting the parasitic epigenome. In the present study, a docking based virtual screening procedure using the cr...

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  • publication . Article . 2015
    Open Access English
    Authors:
    Dmitry Bratanov; Taras Balandin; Ekaterina Round; Vitaly Shevchenko; Ivan Gushchin; Vitaly Polovinkin; Valentin Borshchevskiy; Valentin Gordeliy;
    Publisher: HAL CCSD
    Project: EC | EDICT (201924)

    Published by PLoS, Lawrence

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  • publication . Article . 2020
    Open Access English
    Authors:
    Julia Hennicke; Linda Schwaigerlehner; Clemens Grünwald-Gruber; Isabelle Bally; Wai Li Ling; Nicole M. Thielens; J.-B. Reiser; Renate Kunert;
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: ANR | C1qEffero (ANR-16-CE11-0019), FWF | Biomolecular Technology o... (W 1224), ANR | CBH-EUR-GS (ANR-17-EURE-0003)

    International audience; Recombinant production of IgM antibodies poses a special challenge due to the complex structure of the proteins and their not yet fully elucidated interactions with the immune effector proteins, especially the complement system. In this study, we...

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  • publication . Article . 2017
    Open Access English
    Authors:
    Jonathan Pansieri; Marie Plissonneau; Nathalie Martine Stransky-Heilkron; Mireille Dumoulin; Laurence Heinrich-Balard; Pascaline Rivory; Jean-François Morfin; Éva Tóth; Maria João Saraiva; Eric Allémann; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | EURONANOMED (234811)

    International audience; Gadolinium-based nanoparticles were functionalized with either the Pittsburgh compound B or a nanobody (B10AP) in order to create multimodal tools for an early diagnosis of amyloidoses.MATERIALS & METHODS:The ability of the functionalized nanopar...

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  • publication . Article . 2015
    Open Access English
    Authors:
    Afonso M.S. Duarte; Fotis Psomopoulos; Christophe Blanchet; Alexandre M. J. J. Bonvin; Manuel Corpas; Alain Franc; Rafael C. Jimenez; Jesús Marco de Lucas; Tommi Nyrönen; Gergely Sipos; ...
    Project: FCT | SFRH/BPD/78075/2011 (SFRH/BPD/78075/2011), EC | BIOMEDBRIDGES (284209), WT , AKA | ELIXIR - Data for Life Eu... (273655), FCT | EXPL/BBB-BEP/1356/2013 (134381), EC | WENMR (261572), EC | EGI-INSPIRE (261323)

    This is an open-access article.-- et al.

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  • publication . Article . Other literature type . 2012
    Open Access English
    Authors:
    Jean-Marie Bourhis; Natacha Mariano; Yuguang Zhao; Karl Harlos; Jean-Yves Exposito; E Y Jones; Catherine Moali; Nushin Aghajari; David J.S. Hulmes;
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: WT

    Numerous, often lethal, genetic disorders of bone, cartilage, blood vessels and skin have been linked to defects in the assembly of collagens1. In humans, among the 28 different genetic types of collagen2, those that form the banded fibrils seen in tissues (types I, II,...

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  • publication . Article . 2013
    Open Access English
    Authors:
    Bersch, Beate; Bougault, Catherine M; Roux, Laure; Favier, Adrien; Vernet, Thierry; Durmort, Claire;
    Persistent Identifiers
    Publisher: HAL CCSD

    International audience; Zinc (Zn(2+)) homeostasis is critical for pathogen host colonization and invasion. Polyhistidine triad (Pht) proteins, located at the surface of various streptococci, have been proposed to be involved in Zn(2+) homeostasis. The phtD gene, coding ...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Yoann Millerioux; Muriel Mazet; Guillaume Bouyssou; Stefan Allmann; Tiila Riikka Kiema; Eloïse Bertiaux; Laetitia Fouillen; Chandan J. Thapa; Marc Biran; Nicolas Plazolles; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | PARAMET (290080), ANR | GLYCONOV (ANR-15-CE15-0025), ANR | ParaFrap (ANR-11-LABX-0024)

    Author summary In this study, we have (i) determined the carbon sources used by the Trypanosoma brucei procyclic insect form to feed the essential lipid biosynthetic pathways, (ii) further characterized the metabolic pathways leading to their degradation into acetyl-CoA...

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99 research outcomes, page 1 of 10