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215 research outcomes, page 1 of 22
  • publication . Article . 2019
    Open Access English
    Authors:
    Laura Medve; Silvia Achilli; Joan Guzmán-Caldentey; Michel Thépaut; Luca Senaldi; Aline Le Roy; Sara Sattin; Christine Ebel; Corinne Vivès; Sonsoles Martín-Santamaría; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | IMMUNOSHAPE (642870)

    Abstract Chemical modification of pseudo‐dimannoside ligands guided by fragment‐based design allowed for the exploitation of an ammonium‐binding region in the vicinity of the mannose‐binding site of DC‐SIGN, leading to the synthesis of a glycomimetic antagonist (compoun...

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  • publication . Article . 2014
    Open Access English
    Authors:
    Tim Schulte; Jonas Lofling; Cecilia Mikaelsson; Alexey Kikhney; Karina Hentrich; Aurora Diamante; Christine Ebel; Staffan Normark; Dmitri I. Svergun; Birgitta Henriques-Normark; ...
    Persistent Identifiers
    Publisher: Royal Society Publishing
    Project: EC | BIOSTRUCT-X (283570)

    Streptococcus pneumoniae is a major human pathogen, and a leading cause of disease and death worldwide. Pneumococcal invasive disease is triggered by initial asymptomatic colonization of the human upper respiratory tract. The pneumococcal serine-rich repeat protein (Ps...

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  • publication . Article . 2017
    Open Access English
    Authors:
    Rasa Sukackaite; Daniela Cornacchia; Malene Ringkjøbing Jensen; Philippe J. Mas; Martin Blackledge; Elin Enervald; Guangyou Duan; Tania Auchynnikava; Maja Köhn; Darren J. Hart; ...
    Publisher: HAL CCSD
    Project: WT | How centromeres are speci... (095021), WT | Core funding renewal for ... (092076), EC | EIPOD (229597)

    International audience; Rif1 is a conserved protein that plays essential roles in orchestrating DNA replication timing, controlling nuclear architecture, telomere length and DNA repair. However, the relationship between these different roles, as well as the molecular ba...

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  • publication . Article . 2019
    Open Access English
    Authors:
    Eaazhisai Kandiah; Diego Carriel; Pierre Garcia; Jan Felix; Manuel Banzhaf; George Kritikos; Maria Bacia-Verloop; Céline Brochier-Armanet; Sylvie Elsen; Irina Gutsche;
    Persistent Identifiers
    Project: ANR | Arch-Evol (ANR-16-CE02-0005), EC | Chap4Resp (647784)

    International audience; The only enzyme responsible for cadaverine production in the major multidrug-resistant human pathogen Pseudomonas aeruginosa is the lysine decarboxylase LdcA. This enzyme modulates the general polyamine homeostasis, promotes growth, and reduces b...

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  • publication . Article . 2019
    Open Access
    Authors:
    Ildefonso Marin-Montesinos; David Goyard; Emilie Gillon; Olivier Renaudet; Anne Imberty; Sabine Hediger; Gaël De Paëpe;
    Persistent Identifiers
    Publisher: Royal Society of Chemistry (RSC)
    Project: EC | LEGO (647938), EC | ULT-MAS-DNP (682895), ANR | TransPepNMR (ANR-16-CE11-0030), ANR | ARCANE (ANR-11-LABX-0003)

    Sel-DNP allows selective recovery of high-resolution information from protein binding sites by DNP-enhanced NMR.

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  • publication . Article . 2015
    Open Access English
    Authors:
    Séverine Carrère-Kremer; Mickaël Blaise; Vipul K. Singh; Laeticia Alibaud; Edouard Tuaillon; Iman Halloum; Robert van de Weerd; Yann Guérardel; Michel Drancourt; Howard Takiff; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | BIOSTRUCT-X (283570)

    Nontuberculous mycobacteria are innately resistant to most antibiotics, although the mechanisms responsible for their drug resistance remain poorly understood. They are particularly refractory to thiacetazone (TAC), a second-line antitubercular drug. Herein, we identifi...

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  • publication . Article . 2019
    Open Access
    Authors:
    Federica Laddomada; Mayara M. Miyachiro; Matthew Jessop; Delphine Patin; Viviana Job; Dominique Mengin-Lecreulx; Aline Le Roy; Christine Ebel; Cécile Breyton; Irina Gutsche; ...
    Persistent Identifiers
    Project: EC | Chap4Resp (647784), ANR | BACSCREEN (ANR-13-BSV8-0015)

    International audience; Peptidoglycan is a major component of the bacterial cell wall and thus a major determinant of cell shape. Its biosynthesis is initiated by several sequential reactions catalyzed by cytoplasmic Mur enzymes. Mur ligases (MurC, -D, -E, and -F) are e...

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  • publication . Article . 2018
    Open Access
    Authors:
    K.K. Rasmussen; Anders K. Varming; Simon N. Schmidt; Kristian E. H. Frandsen; Peter W. Thulstrup; Malene Ringkjøbing Jensen; Leila Lo Leggio;
    Publisher: Wiley
    Project: EC | BIOSTRUCT-X (283570)

    Published by Wiley, Chichester

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  • publication . Article . 2016
    Open Access English
    Authors:
    Franck Martin; Jean-François Ménétret; Angelita Simonetti; Alexander G. Myasnikov; Quentin Vicens; Lydia Prongidi-Fix; S. Kundhavai Natchiar; Bruno P. Klaholz; Gilbert Eriani;
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | TRANSLATIONMACHINERY (243296)

    Prokaryotic translation initiation involves mRNA-ribosomal RNA base pairing interactions. Here, the authors provide evidence for a similar base pairing interactions occurring between the human h4 mRNA and helix 16 of the small subunit rRNA to position the correct AUG co...

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  • publication . Article . 2016
    Open Access English
    Authors:
    Tim Schulte; Cecilia Mikaelsson; Audrey Beaussart; Alexey Kikhney; Maya Deshmukh; Sebastian Wolniak; Anuj Pathak; Christine Ebel; Jonas Lofling; Federico Fogolari; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | BIOSTRUCT-X (283570)

    International audience; The major human pathogen Streptococcus pneumoniae is a leading cause of disease and death worldwide. Pneumococcal biofilm formation within the nasopharynx leads to long-term colonization and persistence within the host. We have previously demonst...

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215 research outcomes, page 1 of 22