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149 research outcomes, page 1 of 15
  • publication . Article . 2020
    Open Access English
    Authors:
    Odermatt, Nina,; Lelli, Moreno; Herrmann, Torsten; Abriata, Luciano,; Japaridze, Aleksandre; Voilquin, Hubert; Singh, Rajkumar; Piton, Jérémie; Emsley, Lyndon; Dietler, Giovanni; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | iNEXT (653706)

    Abstract In bacteria, nucleoid associated proteins (NAPs) take part in active chromosome organization by supercoil management, three-dimensional DNA looping and direct transcriptional control. Mycobacterial integration host factor (mIHF, rv1388) is a NAP restricted to A...

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  • publication . Article . Other literature type . Preprint . 2021
    Open Access English
    Authors:
    Maryam Alqabandi; N. de Franceschi; Nolwenn Miguet; Sourav Maity; Marta Bally; Wouter H. Roos; Winfried Weissenhorn; Patricia Bassereau; Stéphanie Mangenot;
    Project: ANR | PSL (ANR-10-IDEX-0001), EC | ESCRT model (751715), ANR | ESCRTfission (ANR-14-CE09-0003), EC | INTERACT (751404), ANR | CBH-EUR-GS (ANR-17-EURE-0003)

    Abstract Background ESCRT-III proteins are involved in many membrane remodeling processes including multivesicular body biogenesis as first discovered in yeast. In humans, ESCRT-III CHMP2 exists as two isoforms, CHMP2A and CHMP2B, but their physical characteristics have...

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  • publication . Article . 2019
    Open Access English
    Authors:
    Koen H. G. Verschueren; Clement Blanchet; Jan Felix; Ann Dansercoer; Dirk De Vos; Yehudi Bloch; Jozef Van Beeumen; Dmitri Svergun; Irina Gutsche; Savvas N. Savvides; ...
    Publisher: HAL CCSD
    Project: EC | iNEXT (653706), EC | Chap4Resp (647784), EC | CALIPSOplus (730872)

    Abstract: Across different kingdoms of life, ATP citrate lyase (ACLY, also known as ACL) catalyses the ATP-dependent and coenzyme A (CoA)-dependent conversion of citrate, a metabolic product of the Krebs cycle, to oxaloacetate and the high-energy biosynthetic precursor ...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Conrad V. Simoben; Dina Robaa; Alokta Chakrabarti; Karin Schmidtkunz; Martin Marek; Julien Lancelot; Srinivasaraghavan Kannan; Jelena Melesina; Tajith B. Shaik; Raymond J. Pierce; ...
    Persistent Identifiers
    Publisher: MDPI
    Project: EC | A-PARADDISE (602080), EC | SETTREND (241865)

    International audience; A promising means in the search of new small molecules for the treatment of schistosomiasis (amongst other parasitic ailments) is by targeting the parasitic epigenome. In the present study, a docking based virtual screening procedure using the cr...

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  • publication . Article . 2017
    Open Access English
    Authors:
    J. Retel; Andrew J. Nieuwkoop; Matthias Hiller; Victoria A. Higman; Emeline Barbet-Massin; Jan Stanek; Loren B. Andreas; W. Trent Franks; Barth-Jan van Rossum; Kutti R. Vinothkumar; ...
    Publisher: HAL CCSD
    Project: EC | iNEXT (653706), EC | BIO-NMR (261863)

    β-barrel proteins mediate nutrient uptake in bacteria and serve vital functions in cell signaling and adhesion. For the 14-strand outer membrane protein G of Escherichia coli, opening and closing is pH-dependent. Different roles of the extracellular loops in this proces...

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  • publication . Article . 2017
    Open Access English
    Authors:
    Pavel Macek; Rime Kerfah; Elisabetta Boeri Erba; Elodie Crublet; Christine Moriscot; Guy Schoehn; Carlos Amero; Jérôme Boisbouvier;
    Persistent Identifiers
    Publisher: American Association for the Advancement of Science
    Project: EC | SEENANOLIFEINACTION (260887)

    The spontaneous formation of biological higher-order structures from smaller building blocks, called self-assembly, is a fundamental attribute of life. Although the protein self-assembly is a time-dependent process that occurs at the molecular level, its current underst...

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  • publication . Article . 2019
    Open Access English
    Authors:
    Cécile Breyton; Waqas Javed; Annelise Vermot; Charles-Adrien Arnaud; Christine Hajjar; Jérôme Dupuy; Isabelle Petit-Hartlein; Aline Le Roy; Anne L. Martel; Michel Thépaut; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: ANR | BANDIT (ANR-17-CE11-0013), EC | SINE2020 (654000), ANR | FLUOR (ANR-16-CE92-0001), NSF | IMR-MIP DANSE - Distribut... (0520547)

    International audience; Laurylmaltose neopentylglycol (LMNG) bears two linked hydrophobic chains of equal length and two hydrophilic maltoside groups. It arouses a strong interest in the field of membrane protein biochemistry, since it was shown to efficiently solubiliz...

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  • publication . Article . 2017
    Open Access English
    Authors:
    Jonathan Pansieri; Marie Plissonneau; Nathalie Martine Stransky-Heilkron; Mireille Dumoulin; Laurence Heinrich-Balard; Pascaline Rivory; Jean-François Morfin; Éva Tóth; Maria João Saraiva; Eric Allémann; ...
    Persistent Identifiers
    Project: EC | EURONANOMED (234811)

    Aim: Gadolinium-based nanoparticles were functionalized with either the Pittsburgh compound B or a nanobody (B10AP) in order to create multimodal tools for an early diagnosis of amyloidoses. Materials & methods: The ability of the functionalized nanoparticles to ta...

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  • publication . Article . 2017
    Open Access English
    Authors:
    Massimiliano Aschi; Argante Bozzi; Carla Luzi; Nadia Bouchemal; Marco Sette;
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | iNEXT (653706)

    A joint application of experimental and computational approaches has revealed the exceptionally high attitude of crabrolin, a 13-residue peptide with sequence FLPLILRKIVTAL-NH2 , to adopt alpha-helix conformation not only in membrane-mimicking solvents but also in the p...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Aurore Cabanettes; Lukas Perkams; Carolina Spies; Carlo Unverzagt; Annabelle Varrot;
    Publisher: HAL CCSD
    Project: EC | iNEXT (653706)

    International audience; We recombinantly produced and characterized the mini fungal lectin PhoSL. Despite a length of only 40 amino acids, PhoSL exclusively recognizes N-glycans with α1,6-linked fucose. Core fucosylation influences the intrinsic properties and bioactivi...

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149 research outcomes, page 1 of 15