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430 research outcomes, page 1 of 43
  • publication . Article . 2019
    Open Access English
    Authors:
    Laura Medve; Silvia Achilli; Joan Guzmán-Caldentey; Michel Thépaut; Luca Senaldi; Aline Le Roy; Sara Sattin; Christine Ebel; Corinne Vivès; Sonsoles Martín-Santamaría; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | IMMUNOSHAPE (642870)

    Abstract Chemical modification of pseudo‐dimannoside ligands guided by fragment‐based design allowed for the exploitation of an ammonium‐binding region in the vicinity of the mannose‐binding site of DC‐SIGN, leading to the synthesis of a glycomimetic antagonist (compoun...

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  • publication . Article . 2014
    Open Access English
    Authors:
    Tim Schulte; Jonas Lofling; Cecilia Mikaelsson; Alexey Kikhney; Karina Hentrich; Aurora Diamante; Christine Ebel; Staffan Normark; Dmitri I. Svergun; Birgitta Henriques-Normark; ...
    Persistent Identifiers
    Publisher: Royal Society Publishing
    Project: EC | BIOSTRUCT-X (283570)

    Streptococcus pneumoniae is a major human pathogen, and a leading cause of disease and death worldwide. Pneumococcal invasive disease is triggered by initial asymptomatic colonization of the human upper respiratory tract. The pneumococcal serine-rich repeat protein (Ps...

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  • publication . Article . 2017
    Open Access English
    Authors:
    Rasa Sukackaite; Daniela Cornacchia; Malene Ringkjøbing Jensen; Philippe J. Mas; Martin Blackledge; Elin Enervald; Guangyou Duan; Tania Auchynnikava; Maja Köhn; Darren J. Hart; ...
    Publisher: HAL CCSD
    Project: WT | How centromeres are speci... (095021), WT | Core funding renewal for ... (092076), EC | EIPOD (229597)

    International audience; Rif1 is a conserved protein that plays essential roles in orchestrating DNA replication timing, controlling nuclear architecture, telomere length and DNA repair. However, the relationship between these different roles, as well as the molecular ba...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Erika Pellegrini; Ambroise Desfosses; Arndt Wallmann; Wiebke Manuela Schulze; Kristina Rehbein; Philippe Mas; Luca Signor; Stephanie Gaudon; Grasilda Zenkeviciute; Michael Hons; ...
    Persistent Identifiers

    Activation of the innate immune pattern recognition receptor NOD2 by the bacterial muramyl-dipeptide peptidoglycan fragment triggers recruitment of the downstream adaptor kinase RIP2, eventually leading to NF-κB activation and proinflammatory cytokine production. Here w...

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  • publication . Article . 2019
    Open Access English
    Authors:
    Eaazhisai Kandiah; Diego Carriel; Pierre Garcia; Jan Felix; Manuel Banzhaf; George Kritikos; Maria Bacia-Verloop; Céline Brochier-Armanet; Sylvie Elsen; Irina Gutsche;
    Persistent Identifiers
    Project: ANR | Arch-Evol (ANR-16-CE02-0005), EC | Chap4Resp (647784)

    International audience; The only enzyme responsible for cadaverine production in the major multidrug-resistant human pathogen Pseudomonas aeruginosa is the lysine decarboxylase LdcA. This enzyme modulates the general polyamine homeostasis, promotes growth, and reduces b...

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  • publication . Article . Preprint . Other literature type . 2018
    Open Access English
    Authors:
    Anne Laure Favier; Olivier Reynard; Evelyne Gout; Martin van Eijk; Henk P. Haagsman; Erika C. Crouch; Viktor E. Volchkov; Christophe N. Peyrefitte; Nicole M. Thielens;
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: ANR | EBODISREG (ANR-14-EBOL-0002)

    International audience; Since the largest 2014⁻2016 Ebola virus disease outbreak in West Africa, understanding of Ebola virus infection has improved, notably the involvement of innate immune mediators. Amongst them, collectins are important players in the antiviral inna...

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  • publication . Article . 2019
    Open Access
    Authors:
    Ildefonso Marin-Montesinos; David Goyard; Emilie Gillon; Olivier Renaudet; Anne Imberty; Sabine Hediger; Gaël De Paëpe;
    Persistent Identifiers
    Publisher: Royal Society of Chemistry (RSC)
    Project: EC | LEGO (647938), EC | ULT-MAS-DNP (682895), ANR | TransPepNMR (ANR-16-CE11-0030), ANR | ARCANE (ANR-11-LABX-0003)

    Sel-DNP allows selective recovery of high-resolution information from protein binding sites by DNP-enhanced NMR.

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  • publication . Article . 2015
    Open Access English
    Authors:
    Séverine Carrère-Kremer; Mickaël Blaise; Vipul K. Singh; Laeticia Alibaud; Edouard Tuaillon; Iman Halloum; Robert van de Weerd; Yann Guérardel; Michel Drancourt; Howard Takiff; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | BIOSTRUCT-X (283570)

    Nontuberculous mycobacteria are innately resistant to most antibiotics, although the mechanisms responsible for their drug resistance remain poorly understood. They are particularly refractory to thiacetazone (TAC), a second-line antitubercular drug. Herein, we identifi...

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  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Mariam El-Khatib; Chady Nasrallah; Julie Lopes; Que-Tien Tran; Guillaume Tetreau; Hind Basbous; Daphna Fenel; Benoit Gallet; Mathilde Lethier; Jean-Michel Bolla; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: ANR | ClickBiofilm (ANR-15-CE18-0005)

    International audience; The gram-negative pathogen Providencia stuartii forms floating communities within which adjacent cells are in apparent contact, before depositing as canonical surface-attached biofilms. Because porins are the most abundant proteins in the outer m...

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  • publication . Article . Preprint . 2017
    Open Access English
    Authors:
    Bastien Dalzon; Catherine Aude-Garcia; Véronique Collin-Faure; Hélène Diemer; David Béal; Fanny Dussert; Daphna Fenel; Guy Schoehn; Sarah Cianférani; Marie Carrière; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: ANR | PAIPITO (ANR-16-CE34-0011), ANR | SERENADE (ANR-11-LABX-0064)

    The technological and economic benefits of engineered nanomaterials may be offset by their adverse effects on living organisms. One of the highly produced nanomaterials under such scrutiny is amorphous silica nanoparticles, which are known to have an appreciable, althou...

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430 research outcomes, page 1 of 43