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390 research outcomes, page 1 of 39
  • publication . Article . 2013
    Open Access English
    Authors:
    Tina Paradzik; Nives Ivić; Zelimira Filic; Babu A. Manjasetty; Paul Herron; Marija Luić; Dušica Vujaklija;
    Persistent Identifiers
    Project: EC | BIOSTRUCT-X (283570), MZOS | Protein-ligand interactio... (098-1191344-2943), MZOS | Fundamental molecular stu... (098-0982913-2877)

    The linear chromosome of Streptomyces coelicolor contains two paralogous ssb genes, ssbA and ssbB. Following mutational analysis, we concluded that ssbA is essential, whereas ssbB plays a key role in chromosome segregation during sporulation. In the ssbB mutant, ∼30% of...

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  • publication . Article . Preprint . Other literature type . 2019
    Open Access English
    Authors:
    Luke R. Lloyd-Jones; Jian Zeng; Julia Sidorenko; Loic Yengo; Gerhard Moser; Kathryn E. Kemper; Huanwei Wang; Zhili Zheng; Reedik Mägi; Tõnu Esko; ...
    Publisher: Nature Publishing Group UK
    Project: EC | ePerMed (692145), NIH | Estimating the frequencie... (5R01MH100141-02), WT | 10,000 UK genome sequence... (091310), NHMRC | Complex trait genomics (1113400), EC | CORBEL (654248), NIH | Genome-Wide Association f... (5R01HL087641-02), NIH | CANDIDATE GENE STUDIES OF... (2R01DK075787-06A1), EC | ENGAGE (201413), NIH | Increasing the power of G... (5R21ES025052-03), NIH | Analysis of Genome-Wide D... (5R01AG042568-03),...

    Accurate prediction of an individual’s phenotype from their DNA sequence is one of the great promises of genomics and precision medicine. We extend a powerful individual-level data Bayesian multiple regression model (BayesR) to one that utilises summary statistics from ...

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  • publication . Article . 2019
    Open Access English
    Authors:
    Aurelia Stangl; Paul R. Elliott; Adan Pinto-Fernandez; Sarah Bonham; Luke B. Harrison; Annalisa Schaub; Kerstin Kutzner; Kirstin Keusekotten; Paul T. Pfluger; Farid El Oualid; ...
    Persistent Identifiers
    Project: UKRI | The ubiquitin-dependent a... (MR/R008582/1), EC | UbiArchitect (724804), EC | BIOSTRUCT-X (283570)

    OTULIN (OTU Deubiquitinase With Linear Linkage Specificity) specifically hydrolyzes methionine1 (Met1)-linked ubiquitin chains conjugated by LUBAC (linear ubiquitin chain assembly complex). Here we report on the mass spectrometric identification of the OTULIN interactor...

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  • publication . Article . 2019
    Open Access English
    Authors:
    Fan, Haitian; Walker, Alexander P; Carrique, Loïc; Keown, Jeremy R; Martin, Itziar Serna; Karia, Dimple; Sharps, Jane; Hengrung, Narin; Pardon, Els; Steyaert, Jan; ...
    Persistent Identifiers
    Project: WT | Purchase of electron micr... (093305), WT | Human Genetics and Diseas... (203141), WT | A mechanistic understandi... (200835), WT | Structural Biology (092931), UKRI | Structure-function relati... (MR/R009945/1), EC | INSTRUCT-ULTRA (731005), UKRI | Replication of influenza ... (MR/K000241/1)

    Influenza A viruses (IAV) are responsible for seasonal epidemics, and pandemics can arise from novel zoonotic influenza A viruses transmitting to humans1,2. IAV contain a segmented negative sense RNA genome that is transcribed and replicated by the viral RNA-dependent R...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Daniel Stöppler; Alex Macpherson; Susanne Smith-Penzel; Nicolas Basse; Fabien Lecomte; Hervé Jean Claude Deboves; Richard D. Taylor; Timothy John Norman; John B. Porter; Lorna C. Waters; ...
    Project: EC | iNEXT (653706), EC | FASTER (741863)

    PLoS Biology, 16 (5)

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  • publication . Article . 2017
    Open Access English
    Authors:
    Rasa Sukackaite; Daniela Cornacchia; Malene Ringkjøbing Jensen; Philippe J. Mas; Martin Blackledge; Elin Enervald; Guangyou Duan; Tania Auchynnikava; Maja Köhn; Darren J. Hart; ...
    Publisher: HAL CCSD
    Project: WT | How centromeres are speci... (095021), WT | Core funding renewal for ... (092076), EC | EIPOD (229597)

    International audience; Rif1 is a conserved protein that plays essential roles in orchestrating DNA replication timing, controlling nuclear architecture, telomere length and DNA repair. However, the relationship between these different roles, as well as the molecular ba...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Erika Pellegrini; Ambroise Desfosses; Arndt Wallmann; Wiebke Manuela Schulze; Kristina Rehbein; Philippe Mas; Luca Signor; Stephanie Gaudon; Grasilda Zenkeviciute; Michael Hons; ...
    Persistent Identifiers

    Activation of the innate immune pattern recognition receptor NOD2 by the bacterial muramyl-dipeptide peptidoglycan fragment triggers recruitment of the downstream adaptor kinase RIP2, eventually leading to NF-κB activation and proinflammatory cytokine production. Here w...

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  • publication . Article . 2017
    Open Access English
    Authors:
    Yizhou Liu; Joshua S. Sharp; Duc Huy Tran Do; Richard A. Kahn; Harald Schwalbe; Florian Buhr; James H. Prestegard;
    Persistent Identifiers
    Project: EC | iNEXT (653706), NIH | NMR APPROACHES TO MEMBRAN... (5R01GM061268-04)

    Mistakes in translation of messenger RNA into protein are clearly a detriment to the recombinant production of pure proteins for biophysical study or the biopharmaceutical market. However, they may also provide insight into mechanistic details of the translation process...

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  • publication . Article . 2013
    Open Access
    Authors:
    Aleksandras Gutmanas; Younes Alhroub; Gary M. Battle; John M. Berrisford; Estelle Bochet; Matthew J. Conroy; Jose M. Dana; Manuel A. Fernandez Montecelo; Glen van Ginkel; Swanand P. Gore; ...
    Persistent Identifiers
    Project: UKRI | CRESTANO - Common REst ap... (BB/K016970/1), WT | Protein Data Bank in Euro... (088944), NIH | Unified Data Resource for... (5R01GM079429-05), UKRI | Validation of biomacromol... (BB/J007471/1), UKRI | GENOME-3D: a UK network p... (BB/I02576X/1), EC | BIOMEDBRIDGES (284209)

    The Protein Data Bank in Europe (pdbe.org) is a founding member of the Worldwide PDB consortium (wwPDB; wwpdb.org) and as such is actively engaged in the deposition, annotation, remediation and dissemination of macromolecular structure data through the single global arc...

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  • publication . Article . 2014
    Open Access
    Authors:
    Shuchismita Dutta; Dimitris Dimitropoulos; Zukang Feng; Irina Persikova; Sanchayita Sen; Chenghua Shao; John D. Westbrook; Jasmine Young; Marina A. Zhuravleva; Gerard J. Kleywegt; ...
    Persistent Identifiers
    Publisher: Wiley
    Project: EC | BIOMEDBRIDGES (284209), UKRI | GENOME-3D: a UK network p... (BB/I02576X/1), NSF | PDB Management by the Res... (0829586), UKRI | Validation of biomacromol... (BB/J007471/1), NIH | Unified Data Resource for... (5R01GM079429-05), UKRI | CRESTANO - Common REst ap... (BB/K016970/1), WT | Protein Data Bank in Euro... (088944)

    With the accumulation of a large number and variety of molecules in the Protein Data Bank (PDB) comes the need on occasion to review and improve their representation. The Worldwide PDB (wwPDB) partners have periodically updated various aspects of structural data represe...

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390 research outcomes, page 1 of 39