Filters (4)
Download Results
114 research outcomes, page 1 of 12
  • publication . Article . 2018
    Open Access English
    Authors:
    Daniel Stöppler; Alex Macpherson; Susanne Smith-Penzel; Nicolas Basse; Fabien Lecomte; Hervé Jean Claude Deboves; Richard D. Taylor; Timothy John Norman; John B. Porter; Lorna C. Waters; ...
    Project: EC | iNEXT (653706), EC | FASTER (741863)

    PLoS Biology, 16 (5)

    Add to ORCIDorcid
  • publication . Other literature type . Article . Preprint . 2019
    Open Access
    Authors:
    Yashwanth Ashok; Moona Miettinen; Danilo Kimio Hirabae de Oliveira; Mahlet Z. Tamirat; Katja Näreoja; Avlokita Tiwari; Michael O. Hottiger; Mark S. Johnson; Lari Lehtiö; Arto T. Pulliainen;
    Publisher: Cold Spring Harbor Laboratory
    Project: AKA | ADP-ribosyltransferase in... (294085), AKA | Novel insights into toxin... (295296), AKA | ADP-ribosyltransferase in... (319299), AKA | EU-OPENSCREEN / Consortiu... (320005), AKA | ADP-ribosyltransferase in... (287063)

    ABSTRACTTargeted pathogen-selective approach to antibiotic development holds promise to minimize collateral damage to the beneficial microbiome. The AB5-topology pertussis toxin (PtxS1-S5, 1:1:1:2:1) is a major virulence factor ofBordetella pertussis, the causative agen...

    Add to ORCIDorcid
  • publication . Article . 2018
    Open Access
    Authors:
    Cecilia de Agrela Pinto; Deni Mance; Tessa Sinnige; Mark Daniëls; Markus Weingarth; Marc Baldus;
    Persistent Identifiers
    Project: EC | iNEXT (653706), NWO | Towards in-situ structura... (2300163571), NWO | Membrane proteins at work... (2300154435)

    The β-barrel assembly machinery (BAM) is a pentameric complex (BamA–E), which catalyzes the essential process of β-barrel protein insertion into the outer membrane of E. coli. Thus far, a detailed understanding of the insertion mechanism has been elusive but recent resu...

    Add to ORCIDorcid
  • publication . Article . Preprint . Other literature type . 2020
    Open Access English
    Authors:
    Brian Bockelman; Andrea Ceccanti; Ian Collier; Linda Cornwall; Thomas Dack; Jaroslav Guenther; Mario Lassnig; Maarten Litmaath; Paul Millar; Mischa Sallé; ...
    Persistent Identifiers
    Publisher: EDP Sciences
    Project: EC | EOSCpilot (739563), EC | AARC2 (730941), NSF | S2I2: Institute for Resea... (1836650), EC | EOSC-hub (777536)

    The WLCG Authorisation Working Group was formed in July 2017 with the objective to understand and meet the needs of a future-looking Authentication and Authorisation Infrastructure (AAI) for WLCG experiments. Much has changed since the early 2000s when X.509 certificate...

    Add to ORCIDorcid
  • publication . Article . 2015
    Open Access English
    Authors:
    Stéphanie Thébault; Morgane Agez; Xiaoke Chi; Johann Stojko; Vincent Cura; Stephanie B. Telerman; Laurent Maillet; Fabien Gautier; Isabelle Billas-Massobrio; Catherine Birck; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: ANR | INRT (ANR-10-LABX-0030), CIHR , ANR | UNISTRA (ANR-10-IDEX-0002)

    International audience; Translationally Controlled Tumor Protein (TCTP) is anti-apoptotic, key in development and cancer, however without the typical Bcl2 family members' structure. Here we report that TCTP contains a BH3-like domain and forms heterocomplexes with Bcl-x...

    Add to ORCIDorcid
  • publication . Article . 2020
    Open Access English
    Authors:
    Jan Mikelson; Mustafa Khammash;
    Publisher: Public Library of Science
    Project: EC | TRANSVAC2 (730964)

    The development of mechanistic models of biological systems is a central part of Systems Biology. One major challenge in developing these models is the accurate inference of model parameters. In recent years, nested sampling methods have gained increased attention in th...

    Add to ORCIDorcid
  • publication . Article . 2018
    Open Access English
    Authors:
    Simonas Masiulis; Rooma Desai; Tomasz Uchański; Itziar Serna Martin; Duncan Laverty; Dimple Karia; Tomas Malinauskas; Jasenko Zivanov; Els Pardon; Abhay Kotecha; ...
    Persistent Identifiers
    Project: SNSF | Modeling of Beam-Induced ... (P2BSP2_168735), SNSF | Le dialoque entre Jean Pa... (81GE-020724), UKRI | Structural analysis of hu... (BB/M024709/1), UKRI | The structural biology of... (MC_UP_1201/15), UKRI | The structural biology of... (MR/L009609/1), UKRI | Visualising proteins in h... (MC_UP_A025_1013)

    Summary Type-A γ-aminobutyric receptors (GABAARs) are ligand-gated chloride channels with a very rich pharmacology. Some of their modulators, including benzodiazepines and general anaesthetics, are among the most successful drugs in clinical use and common substances of...

    Add to ORCIDorcid
  • publication . Article . 2017
    Open Access English
    Authors:
    Vered Israeli-Ruimy; Pedro Bule; Sadanari Jindou; Bareket Dassa; Sarah Moraïs; Ilya Borovok; Yoav Barak; Michal Slutzki; Yuval Hamberg; Vânia Cardoso; ...
    Persistent Identifiers
    Publisher: Nature Publishing Group
    Project: FCT | PTDC/BIA-PRO/103980/2008 (103980), EC | CELLULOSOMEPLUS (604530), FCT | EXPL/BIA-MIC/1176/2012 (129521), EC | WALLTRAC (263916), EC | BIOSTRUCT-X (283570)

    Protein-protein interactions play a vital role in cellular processes as exemplified by assembly of the intricate multi-enzyme cellulosome complex. Cellulosomes are assembled by selective high-affinity binding of enzyme-borne dockerin modules to repeated cohesin modules ...

    Add to ORCIDorcid
  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Marco Schiavina; Maria Grazia Murrali; Letizia Pontoriero; Valerio Sainati; Rainer Kümmerle; Wolfgang Bermel; Roberta Pierattelli; Isabella C. Felli;
    Persistent Identifiers

    Abstract Intrinsically disordered proteins (IDPs) as well as intrinsically disordered regions (IDRs) of complex protein machineries have recently been recognized as key players in many cellular functions. NMR represents a unique tool to access atomic resolution structur...

    Add to ORCIDorcid
  • publication . Preprint . Other literature type . 2020
    Open Access English
    Authors:
    Salla Ruskamo; Oda C. Krokengen; Julia Kowal; Tuomo Nieminen; M. Lehtimaki; Arne Raasakka; Venkata P. Dandey; Ilpo Vattulainen; Henning Stahlberg; Petri Kursula;
    Persistent Identifiers
    Publisher: Cold Spring Harbor Laboratory
    Project: EC | iNEXT (653706), EC | CALIPSOplus (730872)

    AbstractMyelin protein P2 is a peripheral membrane protein of the fatty acid binding protein family. It functions in the formation and maintenance of the peripheral nerve myelin sheath, and several P2 mutations causing human Charot-Marie-Tooth neuropathy have been repor...

    Add to ORCIDorcid
114 research outcomes, page 1 of 12