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112 research outcomes, page 1 of 12
  • publication . Preprint . Other literature type . 2018
    Open Access English
    Authors:
    Galilee, Meytal; Alian, Akram;
    Persistent Identifiers
    Publisher: Cold Spring Harbor Laboratory
    Project: EC | iNEXT (653706)

    ABSTRACTNew anti-AIDS treatments must be continually developed in order to overcome resistance mutations including those emerging in the newest therapeutic target, the viral integrase (IN). Multimerization of IN is functionally imperative and provides a forthcoming ther...

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  • publication . Article . 2020
    Open Access
    Authors:
    Gabriele Stevanato; Gilles Casano; Dominik J. Kubicki; Yu Rao; Laura Esteban Hofer; Georges Menzildjian; Hakim Karoui; Didier Siri; Manuel Cordova; Maxim Yulikov; ...
    Persistent Identifiers
    Project: SNSF | Extending NMR crystallogr... (200020_178860), EC | Oligo-DNP (796904)

    The development of magic-angle spinning dynamic nuclear polarization (MAS DNP) has allowed atomic-level characterization of materials for which conventional solid-state NMR is impractical due to the lack of sensitivity. The rapid progress of MAS DNP has been largely ena...

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  • publication . Article . 2017
    Open Access
    Authors:
    Michal Pellach; Sudipta Mondal; Karl Harlos; Deni Mance; Marc Baldus; Ehud Gazit; Linda J. W. Shimon;
    Publisher: Wiley
    Project: EC | BISON (694426), NWO | Infrastructure for high-r... (2300154217), WT | Understanding the genetic... (090532)

    The crystal structure of a designed phospholipid-inspired amphiphilic phosphopeptide at 0.8 A resolution is presented. The phosphorylated β-hairpin peptide crystallizes to form a lamellar structure that is stabilized by intra- and intermolecular hydrogen bonding, includ...

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  • publication . Article . Other literature type . Preprint . 2017
    Open Access English
    Authors:
    McMurry, Julie A; Juty, Nick; Blomberg, Niklas; Burdett, Tony; Conlin, Tom; Conte, Nathalie; Courtot, Mélanie; Deck, John; Dumontier, Michel; Fellows, Donal K; ...
    Project: EC | BIOMEDBRIDGES (284209), UKRI | Delivering ELIXIR-UK (BB/L005069/1), EC | BioExcel (675728), UKRI | Enriching Metabolic PATHw... (BB/M006891/1), NIH | The Monarch Initiative: L... (5R24OD011883-07), NIH | Center for Expanded Data ... (1U54AI117925-01), NIH | UniProt: A centralized pr... (3U41HG007822-04S1), UKRI | DMMCore: Data and Model M... (BB/M013189/1), EC | ISBE (312455), NIH | Gene Ontology Consortium (5P41HG002273-08),...

    AbstractIn many disciplines, data is highly decentralized across thousands of online databases (repositories, registries, and knowledgebases). Wringing value from such databases depends on the discipline of data science and on the humble bricks and mortar that make inte...

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  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Snir, O.; Chen, X.; Gidoni, M.; Fleur du Pré, M.; Zhao, Y.; Steinsbø, Ø.; Lundin, K.E.A.; Yaari, G.; Sollid, L.M.;
    Persistent Identifiers
    Publisher: American Society for Clinical Investigation (ASCI)
    Project: WT , EC | BIOSTRUCT-X (283570), EC | AUTO-CD (268541)

    The role of B cells and posttranslational modifications in pathogenesis of organ-specific immune diseases is increasingly envisioned but remains poorly understood, particularly in human disorders. In celiac disease, transglutaminase 2–modified (TG2-modified; deamidated)...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Conrad V. Simoben; Dina Robaa; Alokta Chakrabarti; Karin Schmidtkunz; Martin Marek; Julien Lancelot; Srinivasaraghavan Kannan; Jelena Melesina; Tajith B. Shaik; Raymond J. Pierce; ...
    Persistent Identifiers
    Publisher: MDPI
    Project: EC | SETTREND (241865), EC | A-PARADDISE (602080)

    International audience; A promising means in the search of new small molecules for the treatment of schistosomiasis (amongst other parasitic ailments) is by targeting the parasitic epigenome. In the present study, a docking based virtual screening procedure using the cr...

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  • publication . Article . 2015
    Open Access English
    Authors:
    Dmitry Bratanov; Taras Balandin; Ekaterina Round; Vitaly Shevchenko; Ivan Gushchin; Vitaly Polovinkin; Valentin Borshchevskiy; Valentin Gordeliy;
    Publisher: HAL CCSD
    Project: EC | EDICT (201924)

    Published by PLoS, Lawrence

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  • publication . Article . 2017
    Open Access
    Authors:
    Kapishnikov, Sergey; Grolimund, Daniel; Schneider, Gerd; Pereiro, Eva; McNally, James G.; Als-Nielsen, Jens; Leiserowitz, Leslie;
    Persistent Identifiers
    Publisher: Springer Nature
    Project: EC | BIOSTRUCT-X (283570), EC | ELISA (226716)

    Abstract A key drug target for malaria has been the detoxification pathway of the iron-containing molecule heme, which is the toxic byproduct of hemoglobin digestion. The cornerstone of heme detoxification is its sequestration into hemozoin crystals, but how this occurs...

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  • publication . Article . 2017
    Open Access English
    Authors:
    de las Rivas, Matilde; Lira-Navarrete, Erandi; Daniel, Earnest James Paul; Compañón, Ismael; Coelho, Helena; Diniz, Ana; Jiménez-Barbero, Jesús; Peregrina, Jesús M.; Clausen, Henrik; Corzana, Francisco; ...
    Persistent Identifiers
    Project: NIH | Initiation and regulation... (5U01GM113534-03), FCT | UID/Multi/04378/2013 (147258), EC | LTFCOFUND2013 (609409), EC | BIOSTRUCT-X (283570)

    GalNAc transferases’ (GalNAc-Ts) catalytic domains are connected to a lectin domain through a flexible linker. Here the authors present a structural analysis of GalNAc-T4 that implicates the linker region as modulator of the orientations of the lectin domain, which in t...

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  • publication . Article . 2019
    Open Access English
    Authors:
    Norman E. Davey; M. Madan Babu; Martin Blackledge; Alan Bridge; Salvador Capella-Gutierrez; Zsuzsanna Dosztányi; Rachel Drysdale; Richard J. Edwards; Arne Elofsson; Isabella C. Felli; ...
    Publisher: F1000 Research Limited
    Project: EC | IDPfun (778247), UKRI | Bioinformatics Resources ... (BB/P024092/1), NIH | UniProt supporting an int... (3U24HG007822-05S1), WT | Protein Data Bank in Euro... (104948)

    Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) are now recognised as major determinants in cellular regulation. This white paper presents a roadmap for future e-infrastructure developments in the field of IDP research within the ELI...

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112 research outcomes, page 1 of 12