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23 research outcomes, page 1 of 3
  • publication . Article . 2017
    Open Access English
    Authors:
    Vered Israeli-Ruimy; Pedro Bule; Sadanari Jindou; Bareket Dassa; Sarah Moraïs; Ilya Borovok; Yoav Barak; Michal Slutzki; Yuval Hamberg; Vânia Cardoso; ...
    Persistent Identifiers
    Publisher: Nature Publishing Group
    Project: FCT | PTDC/BIA-PRO/103980/2008 (103980), EC | CELLULOSOMEPLUS (604530), FCT | EXPL/BIA-MIC/1176/2012 (129521), EC | WALLTRAC (263916), EC | BIOSTRUCT-X (283570)

    Protein-protein interactions play a vital role in cellular processes as exemplified by assembly of the intricate multi-enzyme cellulosome complex. Cellulosomes are assembled by selective high-affinity binding of enzyme-borne dockerin modules to repeated cohesin modules ...

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  • publication . Other literature type . Preprint . 2020
    Open Access
    Authors:
    Elee Shimshoni; Veronica Ghini; Inna Solomonov; Claudio Luchinat; Irit Sagi; Paola Turano;
    Persistent Identifiers
    Publisher: Cold Spring Harbor Laboratory

    AbstractTwo murine models for colitis were used to study multi-level changes and derive molecular signatures of colitis onset and development. By combining metabolomics data on tissues and fecal extracts with proteomics data on tissues, we provide a comprehensive pictur...

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  • publication . Article . 2015
    Open Access English
    Authors:
    Ison, J.; Rapacki, K.; Mé nager, H.; Kalaš , M.; Rydza, E.; Chmura, P.; Anthon, C.; Beard, N.; ...
    Project: EC | ELIXIR-EXCELERATE (676559), EC | BIOMEDBRIDGES (284209), NIH | Gene Ontology Consortium (5U41HG002273-14)

    Life sciences are yielding huge data sets that underpin scientific discoveries fundamental to improvement in human health, agriculture and the environment. In support of these discoveries, a plethora of databases and tools are deployed, in technically complex and divers...

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  • publication . Other literature type . Preprint . 2018
    Open Access
    Authors:
    Galilee, Meytal; Alian, Akram;
    Persistent Identifiers
    Publisher: Cold Spring Harbor Laboratory
    Project: EC | iNEXT (653706)

    ABSTRACTNew anti-AIDS treatments must be continually developed in order to overcome resistance mutations including those emerging in the newest therapeutic target, the viral integrase (IN). Multimerization of IN is functionally imperative and provides a forthcoming ther...

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  • publication . Article . 2017
    Open Access
    Authors:
    Michal Pellach; Sudipta Mondal; Karl Harlos; Deni Mance; Marc Baldus; Ehud Gazit; Linda J. W. Shimon;
    Project: EC | BISON (694426), NWO | Infrastructure for high-r... (2300154217), WT | Understanding the genetic... (090532)

    Abstract The crystal structure of a designed phospholipid‐inspired amphiphilic phosphopeptide at 0.8 Å resolution is presented. The phosphorylated β‐hairpin peptide crystallizes to form a lamellar structure that is stabilized by intra‐ and intermolecular hydrogen bondin...

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  • publication . Article . 2019
    Open Access
    Authors:
    Y. Halfon; Alicia Jiménez-Fernández; Ruggero La Rosa; Rocio Espinosa Portero; Helle Krogh Johansen; Donna Matzov; Z. Eyal; Anat Bashan; Ella Zimmerman; Matthew J. Belousoff; ...
    Persistent Identifiers
    Publisher: Proceedings of the National Academy of Sciences
    Project: EC | iNEXT (653706), EC | NOVRIB (322581)

    Resistance to antibiotics has become a major threat to modern medicine. The ribosome plays a fundamental role in cell vitality by the translation of the genetic code into proteins; hence, it is a major target for clinically useful antibiotics. We report here the cryo-el...

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  • publication . Article . 2015 . Embargo End Date: 16 Jan 2018
    Open Access
    Authors:
    Huaying Zhao; Rodolfo Ghirlando; Carlos Alfonso; Fumio Arisaka; Ilan Attali; David L. Bain; Marina Bakhtina; Donald F. Becker; Gregory J. Bedwell; Ahmet Bekdemir; ...
    Publisher: Apollo - University of Cambridge Repository
    Project: NIH | Mechanisms for Histone H2... (5R01GM095822-08), NIH | MOLECULAR INTERACTION IN ... (2R01GM029158-19), NIH | SPECIFICITY OF INTERCALAT... (5R01CA035635-13), NIH | Structure and Relations o... (5R01GM015792-39), NIH | The chaperone function of... (5F31GM105363-02), NIH | REGULATION OF UBIQUITINAT... (5R01GM109102-04), NIH | Bacterial Expression Core (5P50GM082545-02), NIH | COBRE on Membrane Protein... (5P30GM103519-04), NIH | Structure and Function of... (3R01GM067777-07S1)

    Peer reviewed

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  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Davey, Norman E.; Babu, M. Madan; Blackledge, Martin; Bridge, Alan; Capella-Gutierrez, Salvador; Dosztanyi, Zsuzsanna; Drysdale, Rachel; Edwards, Richard J.; Elofsson, Arne; Felli, Isabella C.; ...
    Publisher: F1000 Research Limited
    Project: UKRI | Bioinformatics Resources ... (BB/P024092/1), WT | Protein Data Bank in Euro... (104948), NIH | UniProt supporting an int... (3U24HG007822-05S1), EC | IDPfun (778247)

    Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) are now recognised as major determinants in cellular regulation. This white paper presents a roadmap for future e-infrastructure developments in the field of IDP research within the ELI...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Stephen D. Carter; Cheri M. Hampton; Robert Langlois; Roberto Melero; Zachary J. Farino; Michael J. Calderon; Wen Li; Callen T. Wallace; Ngoc-Han Tran; Robert A. Grassucci; ...
    Persistent Identifiers
    Publisher: American Association for the Advancement of Science
    Project: NIH | Dual-Beam Scanning Electr... (1S10RR029300-01), NIH | Request for Ultracryomicr... (1S10RR025488-01), NIH | STRUCTURAL ANALYSIS OF MA... (5R37GM029169-18), EC | QSOX1BIOFUNC (310649), NIH | National Resource for Aut... (7P41GM103310-14), NIH | Endoplasmic Reticulum Mit... (1K01AG045335-01A1), NIH | CANCER CENTER CORE SUPPOR... (3P30CA013696-21S1), NSF | Investigation of the Regu... (1408986), NIH | MICROPLATE SCINTILLATION/... (1S10RR013039-01), NIH | Pharmacologic Treatment o... (5F30NS093798-02),...

    The endoplasmic reticulum (ER) is a highly dynamic network of membranes. Here, we combine live-cell microscopy with in situ cryo-electron tomography to directly visualize ER dynamics in several secretory cell types including pancreatic β-cells and neurons under near-nat...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Assaf Gal; Andrea Sorrentino; Keren Kahil; Eva Pereiro; Damien Faivre; André Scheffel;
    Publisher: HAL CCSD
    Project: EC | BIOSTRUCT-X (283570)

    Calcium storage organelles are common to all eukaryotic organisms and play a pivotal role in calcium signaling and cellular calcium homeostasis. In most organelles, the intraorganellar calcium concentrations rarely exceed micromolar levels. Acidic organelles called acid...

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23 research outcomes, page 1 of 3