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66,642 research outcomes, page 1 of 6,665
  • publication . Article . Other literature type . Preprint . 2017
    Open Access English
    Authors:
    Carlos Eduardo G. Amorim; Ziyue Gao; Zachary Baker; José Francisco Diesel; Yuval B. Simons; Imran S. Haque; Joseph Pickrell; Molly Przeworski;
    Publisher: Public Library of Science
    Project: NIH | Storage System for High P... (1S10OD021764-01), NIH | High-performance compute ... (1S10OD012351-01), NIH | Natural selection in rece... (1R01GM121372-01), NIH | The population genetics o... (5R01GM115889-03)

    Author summary What determines the frequencies of disease mutations in human populations? To begin to answer this question, we focus on one of the simplest cases: mutations that cause completely recessive, lethal Mendelian diseases. We first review theory about what to ...

  • publication . Preprint . 2017
    Open Access
    Authors:
    Yuan, Zuobiao; Zheng, Junyuan; Mei, Zhu; Hu, Guoyong; Zeng, Yue;
    Publisher: Cold Spring Harbor Laboratory

    <jats:title>Abstract</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>The aim of the present investigation is to develop a mouse model of biliary pancreatitis with characteristics of both gallstone formation and pancreatitis, mimicking the human etiology ...

  • publication . Preprint . Other literature type . 2018
    Open Access
    Authors:
    Pertea, Mihaela; Shumate, Alaina; Pertea, Geo; Varabyou, Ales; Chang, Yu-Chi; Madugundu, Anil K.; Pandey, Akhilesh; Salzberg, Steven L.;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | The Comprehensive Proteom... (5U24CA210985-03), NSF | ABI Innovation: Computati... (1458178), NIH | Bioinformatics Software f... (2R01GM083873-05)

    <jats:title>Abstract</jats:title><jats:p>We assembled the sequences from 9,795 RNA sequencing experiments, collected from 31 human tissues and hundreds of subjects as part of the GTEx project, to create a new, comprehensive catalog of human genes and transcripts. The ne...

  • publication . Preprint . 2017
    Open Access English
    Authors:
    Mikhail V. Matz; Eric A. Treml; Galina V. Aglyamova; Madeleine J. H. van Oppen; Line K. Bay;
    Publisher: Cold Spring Harbor Laboratory
    Project: NSF | CAREER: Targets of natura... (1054766)

    Reef-building corals are extremely important for maintenance of marine biodiversity and coastal economy and are currently under severe threat from anthropogenic warming. Warming is predicted to drive preferential survival of warm-adapted genotypes that have migrated to ...

  • publication . Preprint . 2017
    Open Access
    Authors:
    Kovrigin, Evgenii L.;
    Publisher: Cold Spring Harbor Laboratory

    <jats:title>ABSTRACT</jats:title><jats:p>In this paper, I theoretically analyzed ITC profiles for three-state equilibria involving ligand binding coupled to isomerization or dimerization transitions. Simulations demonstrate that the mechanisms where the free or ligand-b...

  • publication . Preprint . Other literature type . 2019
    Open Access English
    Authors:
    Romano, Orso Maria; Cosentino-Lagomarsino, Marco;
    Publisher: Cold Spring Harbor Laboratory

    <jats:title>Abstract</jats:title><jats:p>Growing rod-shaped bacterial cells need to modulate the production rates of different surface and bulk components. Population data show that the balance between these rates is central for cell physiology, and affects cell shape, ...

  • publication . Preprint . 2017
    Open Access
    Authors:
    Rahimi-Balaei, Maryam; Jiao, Xiaodan; Parkinson, Fiona E.; Yeganeh, Behzad; Marzban, Hassan;
    Publisher: Cold Spring Harbor Laboratory

    <jats:title>ABSTRACT</jats:title><jats:p>During cerebellar development, cerebellar nuclei (CN) neurons and Purkinje cells are the earliest born among the different neuronal subtypes. Purkinje cells are the sole output of the cerebellar cortex and project to the CN. The ...

  • publication . Preprint . Other literature type . 2019
    Open Access English
    Authors:
    Bulent Arman Aksoy; Eric Czech; Chrystal Paulos; Jeff Hammerbacher;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Medical University of Sou... (3P30CA138313-02S2)

    <jats:title>Abstract</jats:title><jats:p>Bead-based activation is widely-used for <jats:italic>ex vivo</jats:italic> expansion of T cells for either research or clinical purposes. Despite its wide use, culture conditions that can potentially affect the efficiency of bea...

  • publication . Preprint . Other literature type . 2018
    Open Access English
    Authors:
    Koen J. A. Martens; Sam P. B. van Beljouw; Simon van der Els; Sander Baas; Jochem N. A. Vink; Stan J. J. Brouns; Peter van Baarlen; Michiel Kleerebezem; Johannes Hohlbein;
    Publisher: Cold Spring Harbor Laboratory

    <jats:p>Super-resolution microscopy is frequently employed in the life sciences, but the number of freely accessible and affordable microscopy frameworks, especially for single particle tracking photo-activation localization microscopy (sptPALM), remains limited. To thi...

  • publication . Article . Preprint . Other literature type . 2016
    Open Access
    Authors:
    Marcus Munafo; David Evans; George Davey Smith;
    Publisher: Oxford University Press (OUP)
    Project: RCUK | Statistics and Econometri... (MC_UU_12013/9), RCUK | Accessible resource for i... (BB/I025263/1), WT | The Avon Longitudinal Stu... (102215), RCUK | Data mining and bioinform... (MC_UU_12013/8), RCUK | Using Genetics to Identif... (MC_UU_12013/4), WT , RCUK | From Mendelian Randomizat... (MC_UU_12013/1), RCUK | Determinants, Consequence... (MC_UU_12013/6), RCUK | Epigenetic Epidemiology (MC_UU_12013/2)

    <jats:title>Abstract</jats:title><jats:p>Large-scale cross-sectional and cohort studies have transformed our understanding of the genetic and environmental determinants of health outcomes. However, the representativeness of these samples may be limited – either through ...

66,642 research outcomes, page 1 of 6,665
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