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66,642 research outcomes, page 1 of 6,665
  • publication . Preprint . Other literature type . 2019
    Open Access English
    Authors:
    Kathy Y. Wei; Danai Moschidi; Matthew J. Bick; Santrupti Nerli; Andrew C. McShan; Lauren P. Carter; Po-Ssu Huang; Daniel A. Fletcher; Nikolaos G. Sgourakis; Scott E. Boyken; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | 800 MHz NMR Spectrometer ... (1S10OD018455-01), NIH | Molecular mechanism of an... (1R01AI143997-01), NIH | A Pixel Array Detector Sy... (1S10OD018483-01), NIH | An integrative structural... (5R35GM125034-02), NIH | ALS Efficiently Networkin... (3P30GM124169-02S2), NIH | Eliminating Critical Syst... (1R01GM124149-01)

    <jats:title>Abstract</jats:title><jats:p>The plasticity of naturally occurring protein structures, which can change shape considerably in response to changes in environmental conditions, is critical to biological function. While computational methods have been used to d...

  • publication . Preprint . 2016
    Open Access
    Authors:
    Sharda, Mohak; Seshasayee, Aswin Sai Narain; Khedkar, Supriya;
    Publisher: Cold Spring Harbor Laboratory

    <jats:title>Abstract</jats:title><jats:p>Epigenetic modifications play a key role in gene regulation and in recognition of self DNA in bacteria. In-spite of their positive role in cell survival, modifications like cytosine methylation incur a mutational cost. Cytosine m...

  • publication . Preprint . Other literature type . 2019
    Open Access
    Authors:
    Jenkins, Conor; Rinas, Aimee; Orsburn, Ben;
    Publisher: Cold Spring Harbor Laboratory

    <jats:title>Abstract</jats:title><jats:p>Reporter ion quantification techniques utilizing reagents such as TMT and iTRAQ allow proteomics studies to multiplex up to 11 different samples within a single LC-MS/MS experimental run. In these experiments, peptides derived fr...

  • publication . Article . Preprint . 2016
    Open Access English
    Authors:
    Pedro Garcia da Silva;
    Publisher: Frontiers Media S.A.
    Project: NIH | CRCNS: Theory and experim... (1R01DA036913-01), NIH | NONSPECIFIC THALAMIC INFL... (1K08NS002014-01), NIH | High-throughput DNA seque... (5R01NS073129-02), NIH | CSHL CANCER CENTER SUPPOR... (3P30CA045508-08S1)

    <jats:title>Abstract</jats:title><jats:p>Recombinant Sindbis viruses are important tools in neuroscience because they combine rapid and high transgene expression with a capacity to carry large transgenes. Currently, two packaging systems based on the DH(26S)5’SIN and th...

  • publication . Preprint . Article . 2018
    Open Access
    Authors:
    Daniel K. Okamoto; Stephen C. Schroeter; Daniel C. Reed;
    Publisher: Cold Spring Harbor Laboratory

    <jats:title>Abstract</jats:title><jats:p>Sea urchins are voracious herbivores that influence the ecological structure and function of nearshore ecosystems throughout the world. Like many species that produce planktonic larvae, their recruitment is thought to be particul...

  • publication . Preprint . 2017
    Open Access
    Authors:
    He, Kai; Wan, Tao; Koepfli, Klaus-Peter; Jin, Wei; Liu, Shao-Ying; Jiang, Xue-Long;
    Publisher: Cold Spring Harbor Laboratory

    <jats:title>ABSTRACT</jats:title><jats:p>Biodiversity hotspots should be given high priority for conservation under the situation of global climate change. The sky islands in southwestern China are characterized by extraordinarily high species diversity and are among on...

  • publication . Preprint . 2015
    Open Access
    Authors:
    Betul Kacar;
    Publisher: Cold Spring Harbor Laboratory

    <jats:p>Scientists have access to artifacts of evolutionary history (namely, the fossil record and genomic sequences of living organisms) but they have limited means with which to infer the exact evolutionary events that occurred to produce today s living world. An intr...

  • publication . Preprint . 2016
    Open Access English
    Authors:
    T. Simakova; A. Bragin; M. Zaytseva; C. Clemente; M. Lewicka; J.C. Machado; J.L. Costa; M. Hughes; C. Hertz-Fowler; N. Petrova; ...
    Publisher: Cold Spring Harbor Laboratory

    <jats:title>ABSTRACT</jats:title><jats:p>NGS is a powerful tool for the diagnostics of inherited diseases. A number of studies devoted to the development and validation of targeted NGS panels are published. Here we present not only development and validation of an assay...

  • publication . Preprint . 2019
    Open Access English
    Authors:
    Ian M McDonough; Andrew Bender; Lawrence Patihis; Elizabeth A Stinson; Sarah K Letang; William S Miller;
    Publisher: Cold Spring Harbor Laboratory

    Abstract Functional magnetic resonance imaging (fMRI) is commonly used to investigate the neural bases of behavior ranging from basic cognitive mechanisms to aging to psychological disorders. However, the BOLD signal captured by fMRI is an indirect measure of neural fun...

  • publication . Preprint . 2017
    Open Access
    Authors:
    Castroagudín, Vanina L.; Danelli, Anderson L. D.; Moreira, Silvino I.; Reges, Juliana T. A.; de Carvalho, Giselle; Maciel, João L.N.; Bonato, Ana L. V.; Forcelini, Carlos A.; Alves, Eduardo; McDonald, Bruce A.; ...
    Publisher: Cold Spring Harbor Laboratory

    <jats:title>Abstract</jats:title><jats:p>The wheat blast disease has been a serious constraint for wheat production in Latin America since the late 1980s. We used a population genomics analysis including 95 genome sequences of the wheat blast pathogen <jats:italic>Pyric...

66,642 research outcomes, page 1 of 6,665
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