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66,603 research outcomes, page 1 of 6,661
  • publication . Report . Preprint . 2018
    Open Access
    Authors:
    Mathis, Alexander; Warren, Richard;
    Publisher: Animal Behavior and Cognition
    Project: NIH | Circuit Mechanisms for th... (1F31DC016816-01), EC | ACTIVE SNIFFING (622943)

    <jats:p>Pose estimation is crucial for many applications in neuroscience, biomechanics, genetics and beyond. We recently presented a highly efficient method for markerless pose estimation based on transfer learning with deep neural networks called DeepLabCut. Current ex...

  • publication . Preprint . Article . Other literature type . 2018
    Open Access
    Authors:
    Richard Mooney; Jinghao Lu;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Toward causal neuroscienc... (5DP1MH103908-05), NIH | Functions of distinct tri... (1R21NS101441-01)

    <jats:title>SUMMARY</jats:title><jats:p>In vivo calcium imaging using 1-photon based miniscope and microendoscopic lens enables studies of neural activities in freely behaving animals. However, the high and fluctuating background, the inevitable movements and distortion...

  • publication . Other literature type . Preprint . 2019
    Open Access
    Authors:
    Bálint Kintses; Pramod K. Jangir; Gergely Fekete; Mónika Számel; Orsolya Méhi; Réka Spohn; Lejla Daruka; Ana Martins; Ali Hosseinnia; Alla Gagarinova; ...
    Publisher: bioRxiv
    Project: EC | resistance evolution (648364), WT , CIHR

    Antimicrobial peptides (AMPs) are crucial components of the host immune system and have been proposed as promising novel anti-infectives. However, there is a serious concern that therapeutic application of AMPs would drive bacterial cross-resistance to our own immunity ...

  • publication . Article . Preprint . Other literature type . 2019
    Open Access English
    Authors:
    Zhao Peng; Ely Oliveira-Garcia; Guifang Lin; Ying Hu; Melinda Dalby; Pierre Migeon; Haibao Tang; Mark Farman; David Cook; Frank F. White; ...
    Publisher: Public Library of Science

    Newly emerged wheat blast disease is a serious threat to global wheat production. Wheat blast is caused by a distinct, exceptionally diverse lineage of the fungus causing rice blast disease. Through sequencing a recent field isolate, we report a reference genome that in...

  • publication . Preprint . Other literature type . 2018
    Open Access
    Authors:
    Karl Scheeres; Angela Attwood;
    Publisher: Cold Spring Harbor Laboratory

    <jats:p>Drug-related cognitive biases have been positively associated with drug-craving and increased likelihood of relapse. Cognitive bias modification paradigms have been developed to attenuate cognitive biases but there have been few studies that examined neural resp...

  • publication . Preprint . 2016
    Open Access English
    Authors:
    Piaopiao Chen; Dandan Wang; Han Chen; Zhenzhen Zhou; Xionglei He;
    Publisher: Cold Spring Harbor Laboratory

    <jats:p>Essential genes refer to those whose null mutation leads to lethality or sterility. We propose that the fatal effect of inactivating an essential gene can be attributed to either the loss of indispensable core cellular function (type I), or the gain of fatal sid...

  • publication . Preprint . Other literature type . 2019
    Open Access
    Authors:
    D’Alberto, Brooke M.; Carlson, John K.; Pardo, Sebastián A.; Simpfendorfer, Colin A.;
    Publisher: Cold Spring Harbor Laboratory

    <jats:title>Abstract</jats:title><jats:p>Recent evidence of widespread and rapid declines of wedgefishes, guitarfishes, and banjo ray populations (Order Rhinopristiformes), driven by a high demand for their fins in Asian markets and the quality of their flesh, raises co...

  • publication . Preprint . Other literature type . Article . 2018
    Open Access
    Authors:
    Hillary Koch; Dmytro Starenki; Sara J. Cooper; Richard M. Myers; Qunhua Li;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Statistical methods for i... (5R01GM109453-02), NIH | Computation, Bioinformati... (5T32GM102057-02)

    Author summary A more detailed understanding of the immune response can unlock critical information concerning diagnosis and treatment of disease. Here, in particular, we study T cells through T cell receptor sequencing, as T cells play a vital role in immune response. ...

  • publication . Preprint . 2017
    Open Access
    Authors:
    Himes, Benjamin A.; Zhang, Peijun;
    Publisher: Cold Spring Harbor Laboratory
    Project: WT | Molecular mechanisms of H... (206422), NIH | Structure and function of... (5R01GM085043-05)

    <jats:title>Abstract</jats:title><jats:p>Macromolecular complexes are intrinsically flexible and often challenging to purify for structure determination by single particle cryoEM. Such complexes may be studied <jats:italic>in situ</jats:italic> using cryo-electron tomog...

  • publication . Article . Other literature type . Preprint . 2019
    Open Access
    Authors:
    Balmer, Timothy S; Trussell, Laurence O;
    Publisher: eLife Sciences Publications, Ltd
    Project: NIH | SYNAPTIC MECHANISMS IN TH... (5R01DC004450-04), NIH | Circuitry and physiology ... (5F32DC014878-03), NIH | REGULATION OF SYNAPTIC AM... (2R01NS028901-05), NIH | Identification of inputs ... (1K99DC016905-01A1)

    In vestibular cerebellum, primary afferents carry signals from single vestibular end organs, whereas secondary afferents from vestibular nucleus carry integrated signals. Selective targeting of distinct mossy fibers determines how the cerebellum processes vestibular sig...

66,603 research outcomes, page 1 of 6,661
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