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141,318 research outcomes, page 1 of 14,132
  • publication . Article . Other literature type . 2000
    Open Access
    Authors:
    Ma, Z.; John-Stephen Taylor;
    Publisher: Proceedings of the National Academy of Sciences

    We propose a concept for the rational design and synthesis of highly selective chemotherapeutic agents that makes direct use of genetic information about the disease state. The key idea is to use the mRNA or DNA specific to the disease state to trigger the catalytic rel...

  • publication . Article . Other literature type . 2010
    Open Access
    Authors:
    Hisashi Narimatsu; Takashi Sato; Yuzuru Ikehara; Akira Togayachi;
    Publisher: Proceedings of the National Academy of Sciences

    In a previous study, we demonstrated that β1,3-N-acetylglucosaminyltransferase 5 (B3gnt5) is a lactotriaosylceramide (Lc3Cer) synthase that synthesizes a precursor structure for lacto/neolacto-series glycosphingolipids (GSLs) in in vitro experiments. Here, we generated ...

  • publication . Other literature type . Article . 2019
    Open Access
    Authors:
    Tipton, Laura; Zahn, Geoffrey; Datlof, Erin; Kivlin, Stephanie N.; Sheridan, Patrick; Amend, Anthony S.; Hynson, Nicole A.;
    Publisher: Proceedings of the National Academy of Sciences

    Fungi are ubiquitous and often abundant components of virtually all ecosystems on Earth, serving a diversity of functions. While there is clear evidence that fungal-mediated processes can influence environmental conditions, and in turn select for specific fungi, it is l...

  • publication . Other literature type . Article . 2012
    Open Access
    Authors:
    Perdrizet, G. A.; Artsimovitch, I.; Furman, R.; Sosnick, T. R.; Pan, T.;
    Publisher: Proceedings of the National Academy of Sciences

    Riboswitches are cis-acting elements that regulate gene expression by affecting transcriptional termination or translational initiation in response to binding of a metabolite. A typical riboswitch is made of an upstream aptamer domain and a downstream expression platfor...

  • publication . Article . Other literature type . 2009
    Open Access
    Authors:
    Etienne Schwob; Ivan Minkov; Alexander Strunnikov;

    The CDC14 family of multifunctional evolutionarily conserved phosphatases includes major regulators of mitosis in eukaryotes and of DNA damage response in humans. The CDC14 function is also crucial for accurate chromosome segregation, which is exemplified by its absolut...

  • publication . Other literature type . Article . 1999
    Open Access English
    Authors:
    Valina Dawson;
    Publisher: The National Academy of Sciences

    Neuronal death after ischemic or traumatic injury is mediated, in large part, by excitotoxicity. Originally, it was thought that cell damage by ischemia/reperfusion and other forms of neuronal insults was caused by calcium-mediated activation of phospholipases and prote...

  • publication . Other literature type . Article . 2015
    Open Access English
    Authors:
    Benjamin Vitre; Don W Cleveland;
    Publisher: National Academy of Sciences

    <jats:p>Centrosomes are microtubule-organizing centers that facilitate bipolar mitotic spindle assembly and chromosome segregation. Recognizing that centrosome amplification is a common feature of aneuploid cancer cells, we tested whether supernumerary centrosomes are s...

  • publication . Article . Other literature type . 2006
    Open Access
    Authors:
    LAN Amaral;
    Publisher: Proceedings of the National Academy of Sciences

    Intervality of a food web is related to the number of trophic dimensions characterizing the niches in a community. We introduce here a mathematically robust measure for food web intervality. It has previously been noted that empirical food webs are not strictly interval...

  • publication . Article . Other literature type . 2000
    Open Access
    Authors:
    Liu, S.; Qu, Y.; Stewart, T. J.; Howard, M. J.; Chakrabortty, S.; Holekamp, T. F.; McDonald, J. W.;
    Publisher: Proceedings of the National Academy of Sciences

    Demyelination contributes to the loss of function consequent to central nervous system (CNS) injury. Enhanced remyelination through transplantation of myelin-producing cells may offer a pragmatic approach to restoring meaningful neurological function. An unlimited sourc...

  • publication . Article . Other literature type . 1994
    Open Access
    Authors:
    Masferrer, J L; Zweifel, B S; Manning, P T; Hauser, S D; Leahy, K M; Smith, W G; Isakson, P C; Seibert, K;
    Publisher: Proceedings of the National Academy of Sciences

    Abstract We have examined the role of cyclooxygenase 2 (COX-2) in a model of inflammation in vivo. Carrageenan administration to the subcutaneous rat air pouch induces a rapid inflammatory response characterized by high levels of prostaglandins (PGs) and leukotrienes in...

141,318 research outcomes, page 1 of 14,132
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