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61,310 research outcomes, page 1 of 6,131
  • publication . Article . 2010
    Open Access
    Authors:
    Weinzinger, Anna; Knape, Kirsten; Wacker, Sören J.; Boukharta, Lars; de Groot, Bert L.;
    Publisher: Elsevier BV

    Malfunction of hERG K+ channels, due to inherited mutations or inhibition by drugs can cause long QT syndrome, which may lead to life-threatening arrhythmias. A 3-dimensional hERG structure is a prerequisite to understand the molecular basis of hERG malfunction. To achi...

  • publication . Article . Other literature type . 1972
    Open Access
    Authors:
    Kresch, Edward; Noordergraaf, Abraham;
    Publisher: Elsevier BV

    In order to quantify the collapse phenomenon in veins, this paper presents a mathematical analysis of the cross-sectional shape of a flexible tube as its internal pressure varies. Quantitative results are presented in terms of the physical parameters of the tube, such a...

  • publication . Article . 2012
    Open Access
    Authors:
    Chokshi, Rikki; Matsushita, Masayuki; Kozak, J. Ashot;
    Publisher: Elsevier BV

    TRPM7, a member of transient receptor potential superfamily of ion channels, underlies the Mg2+-inhibited cation currents highly expressed in various cell types of hematopoietic lineage. TRPM7 channels are sensitive to intracellular as well as extracellular Mg2+ and oth...

  • publication . Article . 2011
    Open Access English
    Authors:
    Patel, Hiren; Raval, Gaurav; Nazari, Mozhgan; Heerklotz, Heiko;
    Publisher: Biophysical Society. Published by Elsevier Inc.
    Project: NSERC

    Abstract We have studied the effect of two cosolvents, urea and glycerol, on the association and interactions of a surfactant, octaethyleneglycol dodecyl ether (C12EO8) and a phospholipid (POPC). We have measured the CMC, the partition coefficient, the effective mole fr...

  • publication . Article . 2012
    Open Access
    Authors:
    Catterall, William;
    Publisher: Elsevier BV

    Voltage-gated Na+ channels initiate action potentials in excitable cells and are important targets for drugs. Recent research gives new insight into the structural basis for permeation, drug-block, and voltage-dependent gating. Voltage-sensing depends on the S4 segments...

  • publication . Article . Other literature type . 2009
    Open Access
    Authors:
    Carlo Travaglini-Allocatelli; Alessandro Sicorello; Stefano Gianni; Niccolo Taddei;
    Publisher: Elsevier BV

    AbstractAmyloid fibril formation is a distinctive hallmark of a number of degenerative diseases. In this process, protein monomers self-assemble to form insoluble structures that are generally referred to as amyloid fibrils. We have induced in vitro amyloid fibril forma...

  • publication . Article . 2013
    Open Access
    Authors:
    Kevin Turner; Sidney Elmer; Yooli Light; Eizadora Yu; Aaron Highley; Krystie Nguyen; Darryl Sasaki; Ken Sale; Joseph Schoeniger;
    Publisher: Elsevier BV

    Generally, proteins are comprised of highly complex structures and fluctuations of local or global character are believed to play critical roles in protein function. In the case of E.Coli dihydrofolate reductase (DHFR), previous structural studies have already revealed ...

  • publication . Article . Other literature type . 1997
    Open Access
    Authors:
    Yang, P K; Lee, C Y; Hwang, M J;
    Publisher: Elsevier BV

    Recent studies making use of channel-blocking peptides as molecular calipers have revealed the architecture of the pore-forming region of Shaker-type potassium channels. Here we show that the low-resolution, experimentally derived geometric information can be incorporat...

  • publication . Article . 2011
    Open Access English
    Authors:
    DONG WOOG LEE; Min, Y. J.; Zasadzinski, J. A.; Israelachvili, J. N.;
    Publisher: Biophysical Society. Published by Elsevier Inc.

    Lipid domains indicate the coexistence of thermodynamic phases of lipid molecules at hydrophobic-hydrophilic interface. Domain size, shape and distribution are directly affected by the line tension (λ) and dipole density difference (m) at domain boundaries [1-2]. In thi...

  • publication . Article . 2015
    Open Access
    Authors:
    Krauson, Aram J.; Carattino, Marcelo D.;
    Publisher: Elsevier BV

    Acid sensing ion channels (ASICs) are neuronal cation selective channels that respond to sudden drops in extracellular pH and desensitize in the continuous presence of protons. The mechanism that allows these channels to sense and respond to changes in extracellular pH ...

61,310 research outcomes, page 1 of 6,131
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