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82,114 publications, page 5 of 8,212
  • Preprint English OPEN
    Morquette, Barbara; Juźwik, Camille A.; Drake, Sienna S.; Charabati, Marc; Zhang, Yang; Lécuyer, Marc-André; Galloway, Dylan; Dumas, Aline; de Faria Junior, Omar; Bueno, Mardja; Rambaldi, Isabel; Moore, Craig; Bar-Or, Amit; Vallières, Luc; Prat, Alexandre; ...
    (2018)
    Publisher: Cold Spring Harbor Laboratory
    Abstract Multiple sclerosis (MS) is an autoimmune disease characterized by demyelination and neurodegeneration in the brain, spinal cord and optic nerve. Neuronal degeneration and death underlie progressive forms of MS and cognitive dysfunction. Neuronal damage is trig...
  • Preprint English OPEN
    Yang, Linfeng; Ghosh, Rajarshi. P.; Franklin, J. Matthew; You, Chenyu; Liphardt, Jan T.;
    (2019)
    Publisher: Cold Spring Harbor Laboratory
    Abstract Segmenting cell nuclei within microscopy images is a ubiquitous task in biological research and clinical applications. Unfortunately, segmenting low-contrast overlapping objects that may be tightly packed is a major bottleneck in standard deep learning-based m...
  • Preprint English OPEN
    Exposito-Alonso, Moises; Becker, Claude; Schuenemann, Verena J.; Reiter, Ella; Setzer, Claudia; Slovak, Radka; Brachi, Benjamin; Hagmann, Jörg; Grimm, Dominik G.; Chen, Jiahui; Busch, Wolfgang; Bergelson, Joy; Ness, Rob W.; Krause, Johannes; Burbano, Hernán A.; ...
    (2016)
    Publisher: Cold Spring Harbor Laboratory
    ABSTRACT By following the evolution of populations that are initially genetically homogeneous, much can be learned about core biological principles. For example, it allows for detailed studies of the rate of emergence of de novo mutations and their change in frequenc...
  • Preprint English OPEN
    Liang, Liang; Fratzl, Alex; El Mansour, Omar; Reggiani, Jasmine D.S.; Chen, Chinfei; Andermann, Mark L.;
    (2020)
    Publisher: Cold Spring Harbor Laboratory
    How sensory information is processed by the brain can depend on behavioral state. In the visual thalamus and cortex, arousal/locomotion is associated with changes in the magnitude of responses to visual stimuli. Here, we asked whether such modulation of visual responses...
  • Preprint English OPEN
    Liu, Ming; Kuo, Fengshen; Capistrano, Kristelle J.; Kang, Davina; Nixon, Briana G.; Shi, Wei; Chou, Chun; Do, Mytrang H.; Li, Shun; Stamatiades, Efstathios G.; Chen, Yingbei; Hsieh, James J.; Hakimi, A. Ari; Taniuchi, Ichiro; Chan, Timothy A.; ...
    (2020)
    Publisher: Cold Spring Harbor Laboratory
    Summary The immune system employs two distinct defense strategies against infections: pathogen elimination typified by type 1 immunity, and pathogen containment exemplified by type 2 immunity in association with tissue repair. Akin to infectious diseases, cancer progre...
  • Preprint English OPEN
    Essig, Jaclyn; Hunt, Joshua B.; Felsen, Gidon;
    (2020)
    Publisher: Cold Spring Harbor Laboratory
    Abstract Decision making is critical for survival but its neural basis is unclear. Here we examine how functional neural circuitry in the output layers of the midbrain superior colliculus (SC) mediates spatial choice, an SC-dependent tractable form of decision making. ...
  • Preprint English OPEN
    Vedururu, Ravikiran; Neave, Matthew J.; Tachedjian, Mary; Gorry, Paul R.; Duchemin, Jean-Bernard; Paradkar, Prasad N.;
    (2018)
    Publisher: Cold Spring Harbor Laboratory
    Abstract Chikungunya virus (CHIKV), preferentially transmitted by Aedes mosquitoes, is an emerging pathogen around the world and causes significant morbidity in patients. A single amino acid mutation in the envelope protein of CHIKV has led to shift in vector prefere...
  • Preprint English OPEN
    Ntampaka, Pie; Nyaga, Philip Njeru; Gathumbi, James Kinuthia; Tukei, Michael; Niragire, François;
    (2018)
    Publisher: Cold Spring Harbor Laboratory
    Background: Rabies is a zoonotic viral disease that can occur in all warm-blooded mammals, including man [1]. Vaccinating dogs can protect people from contracting rabies [2]. Annual deaths due to rabies was estimated to 61000 worldwide [1], and Africa represented 35.2% ...
  • Preprint English OPEN
    Damen, Merel P.M.; Phan, Trang H.; Ummels, Roy; Rubio-Canalejas, Alba; Bitter, Wilbert; Houben, Edith N.G.;
    (2020)
    Publisher: Cold Spring Harbor Laboratory
    Abstract Type VII secretion systems (T7SSs) secrete a wide range of extracellular proteins that play important roles in bacterial viability and in host-pathogen interactions of pathogenic mycobacteria. There are five subtypes of mycobacterial T7SSs, called ESX-1 to ESX...
  • Preprint English OPEN
    Shoffner, Suzanne K.; Schnell, Santiago;
    (2015)
    Publisher: Cold Spring Harbor Laboratory
    Fibrillogenesis, the production or development of protein fibers, has been linked to protein folding diseases. The progress curve of fibrils or aggregates typically takes on a sigmoidal shape witha lag phase, a rapid growth phase, and a final plateau regime. The study o...
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