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82,114 publications, page 4 of 8,212
  • Preprint English OPEN
    Xing, Yanru; Yang, Xi; Chen, Haixiao; Zhu, Sujun; Xu, Jinjin; Chen, Yuan; Zeng, Juan; Chen, Fang; Johnson, Mark Richard; Jiang, Hui; Wang, Wen-Jing;
    (2020)
    Publisher: Cold Spring Harbor Laboratory
    Abstract Introduction Peripheral blood leukocytes are essential components of the innate and adaptive immune responses. Their transcriptome reflects an individual’s physiological and pathological state, consequently bulk and single-cell RNA sequencing have been used ...
  • Preprint English OPEN
    Zhan, Jianan; Arking, Dan E.; Bader, Joel S.;
    (2019)
    Publisher: Cold Spring Harbor Laboratory
    Abstract Biological experiments often involve hypothesis testing at the scale of thousands to millions of tests. Alleviating the multiple testing burden has been a goal of many methods designed to boost test power by focusing tests on the alternative hypotheses most li...
  • Preprint English OPEN
    Gong, Chen; Zhang, Meng; Zhang, Yanjie; Liu, Xiang; Liu, Pan; Liao, Xiaoling; Zhou, Yi; Shi, Zhiyue; Liu, Xue;
    (2020)
    Publisher: Cold Spring Harbor Laboratory
    Abstract Environment is capable of affecting our learning ability. Existing studies reported that learning ability can be enhanced by enriched environment and impaired by stressful context. However, it is still unclear whether diversified environment can reverse or ame...
  • Preprint English OPEN
    Bromig, Lukas; Kremling, Andreas; Marin-Sanguino, Alberto;
    (2020)
    Publisher: Cold Spring Harbor Laboratory
    Abstract Systems biology applies concepts from engineering in order to understand biological networks. If such an understanding was complete, biologists would be able to design ad hoc biochemical components tailored for different purposes, which is the goal of synthe...
  • Preprint English OPEN
    Chakrabarti, Anob M.; Henser-Brownhill, Tristan; Monserrat, Josep; Poetsch, Anna R.; Luscombe, Nicholas M.; Scaffidi, Paola;
    (2018)
    Publisher: Cold Spring Harbor Laboratory
    ABSTRACT The CRISPR-Cas9 system has successfully been adapted to edit the genome of various organisms. However, our ability to predict editing accuracy, efficacy and outcome at specific sites is limited by an incomplete understanding of how the bacterial system interac...
  • Preprint English OPEN
    Sim, Joan; Osborne, Kathleen A.; Garcia, Irene Argudo; Matysik, Artur S.; Kraut, Rachel;
    (2016)
    Publisher: Cold Spring Harbor Laboratory
    Abstract Drosophila melanogaster blue cheese ( bchs ) encodes a large BEACH (Beige and Chediak-Higashi) family protein that is postulated to function as an adaptor protein with roles in vesicle trafficking. Mutation in bchs leads to the accumulation of ubiquitinate...
  • Preprint English OPEN
    Diaz, Marvin R; Johnson, Julia M; Varlinskaya, Elena I;
    (2020)
    Publisher: Cold Spring Harbor Laboratory
    Prenatal alcohol exposure (PAE) can result in physical, cognitive, and neurological deficits termed Fetal Alcohol Spectrum Disorder (FASD). Deficits in social functioning associated with PAE are frequently observed and persist throughout the lifespan. Social impairments...
  • Preprint English OPEN
    Coomer, Cagney E.; Wilson, Stephen G.; Titialii-Torres, Kayla F.; Bills, Jessica D.; Krueger, Laura A.; Petersen, Rebecca A.; Turnbaugh, Evelyn M.; Janesch, Eden L.; Morris, Ann C.;
    (2019)
    Publisher: Cold Spring Harbor Laboratory
    Abstract The intrinsic and extrinsic factors that regulate vertebrate photoreceptor specification and differentiation are complex, and our understanding of all the players is far from complete. Her9, the zebrafish ortholog of human HES4, is a basic helix-loop-helix-ora...
  • Preprint English OPEN
    Kinser, Taliesin J.; Smith, Ronald D.; Lawrence, Amelia H.; Cooley, Arielle M.; Vallejo-Marin, Mario; Conradi-Smith, G.D.; Puzey, Joshua R.;
    (2018)
    Publisher: Cold Spring Harbor Laboratory
    ABSTRACT Angiosperm endosperm requires genomic and epigenomic interactions between maternal and paternal genomes for proper seed development. Genomic imprinting, an epigenetic phenomenon where the expression of certain genes is predominantly contributed by one parent, ...
  • Preprint English OPEN
    Prior, Christopher; Davies, Owen R; Bruce, Daniel; Pohl, Ehmke;
    (2019)
    Publisher: Cold Spring Harbor Laboratory
    ABSTRACT Small angle X-ray scattering (SAXS) has become an important tool to investigate the structure of proteins in solution. In this paper we present a novel ab-initio method to represent polypeptide chains as discrete curves that can be used to derive a meaningful ...
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82,114 publications, page 4 of 8,212
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