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82,114 publications, page 2 of 8,212
  • Preprint English OPEN
    Govinda, KC; Hassan, Md Mahmudulla; Sirimulla, Suman;
    (2019)
    Publisher: Cold Spring Harbor Laboratory
    Abstract Kinases are one of the most important classes of drug targets for therapeutic use. Algorithms that can accurately predict the drug-kinase inhibitor constant ( pK i ) of kinases can considerably accelerate the drug discovery process. In this study, we have dev...
  • Preprint English OPEN
    Kajala, Kaisa; Shaar-Moshe, Lidor; Mason, G. Alex; Gouran, Mona; Rodriguez-Medina, Joel; Kawa, Dorota; Pauluzzi, Germain; Reynoso, Mauricio; Canto-Pastor, Alex; Lau, Vincent; Artur, Mariana A. S.; West, Donnelly A.; Manzano, Concepcion; Gray, Sharon B.; Yao, Andrew I.; ...
    (2020)
    Publisher: Cold Spring Harbor Laboratory
    Abstract Plant species have evolved myriads of solutions to adapt to dynamic environments, including complex cell type development and regulation. To understand this diversity, we profiled tomato root cell type translatomes and chromatin accessibility. Using xylem diff...
  • Preprint English OPEN
    Pawlikowski, Bradley; Betta, Nicole Dalla; Antwine, Tiffany; Olwin, Bradley B.;
    (2019)
    Publisher: Cold Spring Harbor Laboratory
    Summary Skeletal muscle maintenance and repair is dependent on the resident adult muscle stem cell (MuSC). During injury, and in diseased muscle, stem cells are engaged to replace or repair damaged muscle, which requires the stem cells to exit quiescence and expand, fo...
  • Preprint English OPEN
    Lin, Meng; Caberto, Christian; Wan, Peggy; Li, Yuqing; Lum-Jones, Annette; Tiirikainen, Maarit; Pooler, Loreall; Nakamura, Brooke; Sheng, Xin; Porcel, Jacqueline; Lim, Unhee; Setiawan, Veronica Wendy; Marchand, Loïc Le; Wilkens, Lynne R.; Haiman, Christopher A.; ...
    (2019)
    Publisher: Cold Spring Harbor Laboratory
    Abstract Statistical imputation applied to genome-wide array data is the most cost-effective approach to complete the catalog of genetic variation in a study population. However, imputed genotypes in underrepresented populations incur greater inaccuracies due to ascert...
  • Preprint English OPEN
    Jain, Shanu; Pydi, Sai P.; Toti, Kiran S.; Robaye, Bernard; Idzko, Marco; Gavrilova, Oksana; Wess, Jürgen; Jacobson, Kenneth A.;
    (2020)
    Publisher: Cold Spring Harbor Laboratory
    ABSTRACT Uridine diphosphate (UDP)-activated purinergic receptor P2Y 6 (P2Y 6 R) plays a crucial role in controlling energy balance through central mechanisms. However, P2Y 6 R’s roles in peripheral tissues regulating energy and glucose homeostasis remain unexplored. ...
  • Preprint English OPEN
    Guilherme, Adilson; Pedersen, David J; Henriques, Felipe; Bedard, Alexander H.; Henchey, Elizabeth; Kelly, Mark; Rahmouni, Kamal; Morgan, Donald A.; Czech, Michael P;
    (2018)
    Publisher: Cold Spring Harbor Laboratory
    ABSTRACT White adipose tissue (WAT) secretes factors to communicate with other metabolic organs to maintain energy homeostasis. We previously reported that perturbation of adipocyte de novo lipogenesis (DNL) by deletion of fatty acid synthase (FASN) causes expansion of...
  • Preprint English OPEN
    Nardin, Luis G.; Miller, Craig R.; Ridenhour, Benjamin J.; Krone, Stephen M.; Joyce, Paul; Baumgaertner, Bert O.;
    (2016)
    Publisher: Cold Spring Harbor Laboratory
    Abstract Human behavior can change the spread of infectious disease. There is limited understanding of how the time in the future over which individuals make a behavioral decision, their planning horizon, affects epidemic dynamics. We developed an agent-based model (al...
  • Preprint English OPEN
    Sun, Chao; Nold, Andreas; Tchumatchenko, Tatjana; Heilemann, Mike; Schuman, Erin M.;
    (2020)
    Publisher: Cold Spring Harbor Laboratory
    Abstract An individual neuron hosts up to 10,000 individual synapses that can be made stronger or weaker by local and cell-wide plasticity mechanisms, both of which require protein synthesis. To address over what spatial scale a neuron allocates synaptic resources, we ...
  • Preprint English OPEN
    Pereira, Henrique M.; Rosa, Isabel M.D.; Martins, Inês S.; Kim, HyeJin; Leadley, Paul; Popp, Alexander; van Vuuren, Detlef P.; Hurtt, George; Anthoni, Peter; Arneth, Almut; Baisero, Daniele; Chaplin-Kramer, Rebecca; Chini, Louise; Di Fulvio, Fulvio; Di Marco, Moreno; ...
    (2020)
    Publisher: Cold Spring Harbor Laboratory
    Abstract Despite the scientific consensus on the extinction crisis and its anthropogenic origin, the quantification of historical trends and of future scenarios of biodiversity and ecosystem services has been limited, due to the lack of inter-model comparisons and harm...
  • Preprint English OPEN
    Kranz, Emiko; Chan, Joshua; Hashimoto, Maya; Kanazawa, Toshio; Wang, Hanlu; Kamata, Masakazu;
    (2020)
    Publisher: Cold Spring Harbor Laboratory
    Abstract The use of chimeric antigen receptor modified-T (CAR-T) cells in adoptive immunotherapy has been popularized through recent success in the field of cancer treatment research. CD4ζ CAR, which targets HIV-1-infected cells, has been developed and evaluated in pat...
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