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353 research outcomes, page 5 of 36
  • publication . Article . 2013
    Open Access
    Authors:
    Gross, Joachim; Baillet, Sylvain; Barnes, Gareth R.; Henson, Richard N.; Hillebrand, Arjan; Jensen, Ole; Jerbi, Karim; Litvak, Vladimir; Maess, Burkhard; Oostenveld, Robert; ...
    Publisher: Elsevier BV
    Project: WT | Natural and modulated neu... (098433), WT | Core support for the Well... (091593), WT | Neural mechanisms of sens... (091928), EC | MINDTIME (263584)

    Magnetoencephalographic (MEG) recordings are a rich source of information about the neural dynamics underlying cognitive processes in the brain, with excellent temporal and good spatial resolution. In recent years there have been considerable advances in MEG hardware de...

  • publication . Article . 2013
    Open Access
    Authors:
    Wittmann, Bianca C.; Tan, Geoffrey C.; Lisman, John E.; Dolan, Raymond J.; Düzel, Emrah;
    Publisher: Elsevier BV
    Project: WT | Core support for the Well... (091593), WT | The neurobiology of motiv... (098362)

    Previous studies have shown that appetitive motivation enhances episodic memory formation via a network including the substantia nigra / ventral tegmental area (SN/VTA), striatum and hippocampus. This functional magnetic resonance imaging (fMRI) study now contrasted the...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Rutledge, Robb B.; Moutoussis, Michael; Smittenaar, Peter; Zeidman, Peter; Taylor, Tanja; Hrynkiewicz, Louise; Lam, Jordan; Skandali, Nikolina; Siegel, Jenifer Z.; Ousdal, Olga T.; ...
    Publisher: American Medical Association (AMA)
    Project: WT | Core support for the Well... (091593), WT | The Cambridge-UCL Mental ... (095844), WT | The neurobiology of motiv... (098362)

    Importance: Major depressive disorder (MDD) is associated with deficits in representing reward prediction errors (RPEs), which are the difference between experienced and predicted reward. Reward prediction errors underlie learning of values in reinforcement learning mod...

  • publication . Article . 2013
    Open Access English
    Authors:
    Nicholas D Wright; Mkael Symmonds; Laurel S Morris; Raymond J Dolan;
    Publisher: Public Library of Science
    Project: WT | The role of emotion in de... (078865), WT | Core support for the Well... (091593)

    Asymmetry in distributions of potential outcomes (i.e. skewness), and whether those potential outcomes reflect gains or losses (i.e. their valence), both exert a powerful influence on value-based choice. How valence affects the impact of skewness on choice is unknown. H...

  • publication . Article . 2017
    Open Access English
    Authors:
    Hauser, Tobias U; Allen, Micah; Purg, Nina; Moutoussis, Michael; Rees, Geraint; Dolan, Raymond J;
    Publisher: ELIFE SCIENCES PUBLICATIONS LTD
    Project: WT | The Conscious Phenotype. (100227), WT | The neurobiology of motiv... (098362), WT | Core support for the Well... (091593), WT | The Cambridge-UCL Mental ... (095844)

    Impairments in metacognition, the ability to accurately report one’s performance, are common in patients with psychiatric disorders, where a putative neuromodulatory dysregulation provides the rationale for pharmacological interventions. Previously, we have shown how un...

  • publication . Article . 2019
    Open Access English
    Authors:
    Rigoli, F.; Michely, J.; Friston, K. J.; Dolan, R. J.;
    Publisher: Masson
    Project: WT | Functional architectures ... (088130), WT | The neurobiology of motiv... (098362), WT | Core support for the Well... (091593)

    Making inference under uncertainty requires an optimal weighting of prior expectations and observations. How this weighting is realized in the brain remains elusive. To investigate this, we recorded functional neuroimaging data while participants estimated a number base...

  • publication . Article . 2016
    Open Access English
    Authors:
    Rigoli, F.; Rutledge, R.B.; Dayan, P.; Dolan, R.J.;
    Publisher: Academic Press
    Project: WT | Core support for the Well... (091593), WT | The neurobiology of motiv... (098362)

    Decision theories mandate that organisms should adjust their behaviour in the light of the contextual reward statistics. We tested this notion using a gambling choice task involving distinct contexts with different reward distributions. The best fitting model of subject...

  • publication . Article . 2016
    Open Access English
    Authors:
    Schwartenbeck, Philipp; Friston, Karl;
    Publisher: Society for Neuroscience
    Project: WT | Core support for the Well... (091593)

    Abstract Computational psychiatry is a rapidly emerging field that uses model-based quantities to infer the behavioral and neuronal abnormalities that underlie psychopathology. If successful, this approach promises key insights into (pathological) brain function as well...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Seif, M.; Wheeler-Kingshott, C.; Cohen-Adad, J.; Flanders, A.; Freund, P.;
    Publisher: Nature Publishing Group
    Project: WT | Core support for the Well... (091593), EC | NISCI (681094), EC | CDS-QUAMRI (634541)

    Traumatic spinal cord injury (SCI) leads to immediate neuronal and axonal damage at the focal injury site and triggers secondary pathologic series of events resulting in sensorimotor and autonomic dysfunction below the level of injury. Although there is no cure for SCI,...

  • publication . Article . 2013
    Open Access English
    Authors:
    Mkael Symmonds; Nicholas D Wright; Elizabeth Fagan; Raymond J Dolan;
    Publisher: Public Library of Science
    Project: WT | Core support for the Well... (091593), WT | The neurobiology of motiv... (098362)

    In humans, dopamine is implicated in reward and risk-based decision-making. However, the specific effects of dopamine augmentation on risk evaluation are unclear. Here we sought to measure the effect of 100 mg oral levodopa, which enhances synaptic release of dopamine, ...

353 research outcomes, page 5 of 36
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