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416 research outcomes, page 4 of 42
  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Müller, Christian P; Chu, Congying; Qin, Liya; Liu, Chunyu; Xu, Bing; Gao, He; Ruggeri, Barbara; Hieber, Saskia; Schneider, Julia; Jia, Tianye; ...
    Publisher: Uppsala universitet, Institutionen för farmaceutisk biovetenskap
    Project: SFI | The Neurobiology of Volun... (16/ERCD/3797), EC | EU-AIMS (115300), NIH | Axon, Testosterone and Me... (5R01MH085772-02), EC | MATRICS (603016), NIH | THE FRAMINGHAM HEART STUD... (N01HC025195-005), EC | IMAGEMEND (602450), EC | STRATIFY (695313), NIH | ENIGMA Center for Worldwi... (3U54EB020403-04S1)

    Alcohol abuse is a major public health problem worldwide. Understanding the molecular mechanisms that control regular drinking may help to reduce hazards of alcohol consumption. While immunological mechanisms have been related to alcohol drinking, most studies reported ...

  • publication . Article . 2018
    Open Access
    Authors:
    Nayor, Matthew; Wang, Na; Larson, Martin G.; Vasan, Ramachandran S.; Levy, Daniel; Ho, Jennifer E.;
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Project: NIH | TRAINING PROGRAM IN CARDI... (2T32HL007604-06), NIH | The Role of Galectin-3 in... (7K23HL116780-04), NIH | THE FRAMINGHAM HEART STUD... (N01HC025195-005)

    Background Circulating Galectin‐3 (Gal‐3) concentrations are associated with an increased incidence of heart failure, atrial fibrillation, chronic kidney disease, and mortality. Recent evidence suggests that Gal‐3 may also be an important modulator of cardiometabolic tr...

  • publication . Article . 2014
    Open Access
    Authors:
    Dongdong eLin; Dongdong eLin; Jigang eZhang; Jigang eZhang; Jingyao eLi; Jingyao eLi; Hao eHe; Hao eHe; hong-wen eDeng; hong-wen eDeng; ...
    Publisher: Frontiers Media SA
    Project: NIH | Integration of brain imag... (5R01MH104680-03), NIH | THE FRAMINGHAM HEART STUD... (N01HC025195-005), NIH | ROBUST AND POWERFUL TEST ... (5R01AR050496-05), NIH | Genomic search for bone m... (7R01AG026564-05), NIH | Identification of Protein... (5R01AR057049-06), NIH | Biostatistics and Bioinfo... (5P50AR055081-03), NIH | Integration of multiscale... (5R01GM109068-04), NIH | Epigenomewide DNA Methyla... (5R01AR059781-02)

    A variety of high throughput genome-wide assays enable the exploration of genetic risk factors underlying complex traits. Although these studies have remarkable impact on identifying susceptible biomarkers, they suffer from issues such as limited sample size and low rep...

  • publication . Article . Other literature type . 2015
    Open Access
    Authors:
    Wang, Leyao; Murk, William; DeWan, Andrew T.;
    Publisher: Public Library of Science (PLoS)
    Project: NIH | SUBCLINICAL CARDIOVASCULA... (N01HC095161-000), CIHR , NIH | SUBCLINICAL CARDIOVASCULA... (N01HC095166-002), NIH | SUBCLINICAL CARDIOVASCULA... (N01HC095167-000), NIH | SUBCLINICAL CARDIOVASCULA... (N01HC095160-000), NIH | THE FRAMINGHAM HEART STUD... (N01HC025195-005), NIH | Adapting the RAO Model to... (3UL1RR024156-02S1), NIH | SUBCLINICAL CARDIOVASCULA... (N01HC095163-000), NIH | SUBCLINICAL CARDIOVASCULA... (N01HC095168-000), NIH | SUBCLINICAL CARDIOVASCULA... (N01HC095164-002),...

    Asthmatics have an increased risk of being overweight/obese. Although the underlying mechanisms of this are unclear, genetic factors are believed to play an essential role. To identify common genetic variants that are associated with asthma-related BMI increase, we perf...

  • publication . Article . Other literature type . 2012
    Open Access English
    Authors:
    Preis, S. R.; Pencina, M. J.; D'Agostino, R. B.; Meigs, J. B.; Vasan, R. S.; Fox, C. S.;
    Publisher: American Diabetes Association
    Project: NIH | Epidemiology of Precursor... (5K24DK080140-03), NIH | THE FRAMINGHAM HEART STUD... (N01HC025195-005), NIH | Biomarkers of Metabolic a... (5R01DK080739-03)

    Upper-body subcutaneous adipose tissue, estimated by neck circumference (NC), is a unique fat depot that may confer additional risk for metabolic risk factors over generalized and central adiposity (1). Using a prospective study design, we now evaluate whether NC improv...

  • publication . Article . 2019
    Open Access English
    Authors:
    Zheng, Sarah; Lubin, Benjamin; Au, Rhoda; Murabito, Joanne M.; Benjamin, Emelia J.; Shwartz, Michael;
    Project: NIH | Precursors and Prognosis ... (1R56NS089607-01), NIH | MRI, Cognitive, Genetic a... (2R01AG033040-06), NIH | AFGen Consortium: Atrial ... (1R01HL128914-01), NIH | THE FRAMINGHAM HEART STUD... (N01HC025195-005), NIH | American Heart Associatio... (3P50HL120163-03S1), NIH | Chronic Traumatic Encepha... (5U01NS093334-02), NIH | Re-visiting Methods for M... (1R01AG049810-01A1), NIH | MRI, Genetics & Cognitive... (4R01AG016495-15), NIH | Impact of Traumatic Brain... (1R21HD089088-01), NIH | Plasma Amylin Impact on C... (5R01AG049899-04),...

    Background: The few studies that have examined the relationship between midlife cardiovascular disease risk and longer-term costs have differentiated risk using a small number of risk categories. In this paper, we illustrate the advantages of a continuous-valued score t...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Hollander, Wouter den; Boer, Cindy G.; Hart, Deborah J.; Yau, Michelle S.; Ramos, Yolande F.M.; Metrustry, Sarah; Broer, Linda; Deelen, Joris; Cupples, L. Adrienne; Rivadeneira, Fernando; ...
    Project: NIH | THE FRAMINGHAM HEART STUD... (N01HC025195-005), EC | IDEAL (259679), NWO | NCHA Subsidiebesluit 2008... (2300155116), NIH | Translational Research in... (3T32AG023480-10S1)

    <jats:sec><jats:title>Objective</jats:title><jats:p>Osteoarthritis (OA) is the most common form of arthritis and the leading cause of disability in the elderly. Of all the joints, genetic predisposition is strongest for OA of the hand; however, only few genetic risk loc...

  • publication . Article . 2019
    Open Access English
    Authors:
    Milka Koupenova; Eric Mick; Heather A. Corkrey; Anupama Singh; Selim E. Tanriverdi; Olga Vitseva; Daniel Levy; Allison M. Keeler; Marzieh Ezzaty Mirhashemi; Mai K. ElMallah; ...
    Publisher: Elsevier
    Project: NIH | THE FRAMINGHAM HEART STUD... (N01HC025195-005), NIH | Racial and Ethnic Diversi... (5U01HL126495-04), NIH | Extracellular RNAs: Bioma... (3UH3TR000921-04S1)

    Summary The presence of nonhuman RNAs in man has been questioned and it is unclear if food-derived miRNAs cross into the circulation. In a large population study, we found nonhuman miRNAs in plasma by RNA sequencing and validated a small number of pine-pollen miRNAs by ...

  • publication . Article . 2015
    Open Access English
    Authors:
    Hochner H; Catherine Allard; Granot-Hershkovitz E; Chen J; Cm, Sitlani; Sazdovska S; Lumley T; McKnight B; Rice K; Da, Enquobahrie; ...
    Publisher: Public Library of Science
    Project: NIH | Rare Sequence Variation a... (2R01DK078616-08), EC | ENGAGE (201413), NIH | Epidemiology of Precursor... (5K24DK080140-03), NIH | THE FRAMINGHAM HEART STUD... (N01HC025195-005), NIH | Maternal Obesity, Fetal G... (1R01HL088884-01), NWO | Dissecting genetic comple... (2300137747)

    Author Summary To date, genetic variants identified in large-scale genetic studies using recent technical and methodological advances explain only a small proportion of the genetic basis of obesity, diabetes and other cardiovascular risk factors. These studies were typi...

  • publication . Preprint . Other literature type . 2018
    Open Access
    Authors:
    Dashti, Hassan S; Jones, Samuel E; Wood, Andrew R; Lane, Jacqueline M; van Hees, Vincent T.; Wang, Heming; Rhodes, Jessica A; Song, Yanwei; Patel, Krunal; Anderson, Simon G; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: WT | Using genetics to underst... (104150), NIH | Training in Sleep, Circad... (5T32HL007901-15), NIH | THE FRAMINGHAM HEART STUD... (N01HC025195-005), NIH | CARDIOVASCULAR RISK IN SL... (5U01HL053941-04), NIH | Melatonin and Receptor Ge... (5R01DK102696-02), NIH | Genetics of chronotype an... (5R01DK107859-03), NIH | Phenotypic and Molecular ... (1R35HL135818-01), NIH | EARLY LIFE CORRELATES OF ... (5R01HL035740-02), EC | GLUCOSEGENES (323195), NIH | Impact of genetic variant... (5F32DK102323-02),...

    <jats:title>Abstract</jats:title><jats:p>Sleep is an essential homeostatically-regulated state of decreased activity and alertness conserved across animal species, and both short and long sleep duration associate with chronic disease and all-cause mortality<jats:sup>1,2...

416 research outcomes, page 4 of 42
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