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416 research outcomes, page 2 of 42
  • publication . Article . Other literature type . 2008
    Open Access English
    Authors:
    C. S. Fox; M. J. Pencina; P. W.F. Wilson; N. P. Paynter; R. S. Vasan; R. B. D'Agostino;
    Publisher: American Diabetes Association
    Project: NIH | THE FRAMINGHAM HEART STUD... (N01HC025195-005), NIH | Aldosterone in Vascular R... (2K24HL004334-04)

    OBJECTIVE—We assessed the lifetime risk of cardiovascular disease (CVD) among individuals with and without obesity and diabetes. RESEARCH DESIGN AND METHODS—Participants were drawn from the original and offspring cohorts of the Framingham Heart Study. Lifetime (30-year)...

  • publication . Article . Other literature type . 2012
    Open Access English
    Authors:
    Alex Hewitt;
    Publisher: SpringerLink
    Project: WT | ALSPAC: consolidation of ... (076467), NHMRC | Genes and Environment in ... (512423), NHMRC | DISSECTING THE GENETICS O... (350415), NIH | International Collaborati... (5R01EY018246-03), NIH | CTSA INFRASTRUCTURE FOR A... (1UL1RR033176-01), NHMRC | Eye disease, diet and vas... (974159), EC | ENGAGE (201413), NIH | Multi-Ethnic Study of Ath... (3R01HL071205-04S1), AKA | Impact of childhood growt... (134309), AKA | Center of Excellence in C... (129680),...

    Myopia is a complex genetic disorder and a common cause of visual impairment among working age adults. Genome-wide association studies have identified susceptibility loci on chromosomes 15q14 and 15q25 in Caucasian populations of European ancestry. Here, we present a co...

  • publication . Article . 2018
    Open Access English
    Authors:
    Siyouneh Baghdasarian; Hsuan-Ping Lin; Richard Pickering; Melanie Mott; Martha Singer; M. Bradlee; Lynn Moore;
    Publisher: MDPI
    Project: NIH | THE FRAMINGHAM HEART STUD... (N01HC025195-005)

    Identification of diet and lifestyle risk factors for prevention of type 2 diabetes mellitus (T2DM) is of great importance. The specific role of dietary cholesterol (DC) in T2DM risk is unclear. This study uses data from 2192 Framingham Offspring Study subjects to estim...

  • publication . Article . Other literature type . 2014
    Open Access English
    Authors:
    Wen-Hua Wei; Yunfei Guo; Alida S.D. Kindt; Tony R. Merriman; Colin A. Semple; Kai Wang; Chris S. Haley;
    Publisher: Oxford University Press
    Project: NIH | COMMUNITY AND COHORT SURV... (N01HC055015-028), NIH | Genome-Wide Association f... (5R01HL087641-02), NIH | Institute for Clinical an... (3UL1RR025005-03S2), NIH | CENTRAL HEMOSTATIS LABORA... (N01HC055022-018), NIH | A Genome-Wide Association... (5R01HL086694-05), NIH | GWA for Gene-Environment ... (5U01HG004402-02), NIH | CCSP - FIELD CENTER AND U... (N01HC055018-017), NIH | CCSP - FIELD CENTER (N01HC055020-003), NIH | Integrated Variation Dete... (7R01HG006465-06), NIH | THE FRAMINGHAM HEART STUD... (N01HC025195-005),...

    Human serum uric acid concentration (SUA) is a complex trait. A recent meta-analysis of multiple genome-wide association studies (GWAS) identified 28 loci associated with SUA jointly explaining only 7.7% of the SUA variance, with 3.4% explained by two major loci (SLC2A9...

  • publication . Article . 2013
    Open Access
    Authors:
    Mihaescu, Raluca; Pencina, Michael J; Alonso, Alvaro; Lunetta, Kathryn L; Heckbert, Susan R; Benjamin, Emelia J; JW Janssens, A;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | THE FRAMINGHAM HEART STUD... (N01HC025195-005), NIH | Risk prediction of atrial... (5RC1HL101056-02), NIH | Patterns of Health Care U... (5R01HL102214-03), NIH | Epidemiologic Study of Ri... (1RC1HL099452-01)

    textabstractBackground: It is often assumed that rare genetic variants will improve available risk prediction scores. We aimed to estimate the added predictive ability of rare variants for risk prediction of common diseases in hypothetical scenarios.Methods: In simulate...

  • publication . Article . 2017
    Open Access English
    Authors:
    S. Hong Lee; W. M. Shalanee P. Weerasinghe; Naomi R. Wray; Michael E. Goddard; Julius H. J. van der Werf;
    Publisher: Nature Publishing Group
    Project: NHMRC | Using genomics to underst... (1078901), NHMRC | Advanced whole-genome app... (1080157), NHMRC | Multivariate whole genome... (1087889), NIH | THE FRAMINGHAM HEART STUD... (N01HC025195-005), ARC | Future Fellowships - Gran... (FT160100229), ARC | Discovery Projects - Gran... (DP160102126)

    Genomic prediction shows promise for personalised medicine in which diagnosis and treatment are tailored to individuals based on their genetic profiles for complex diseases. We present a theoretical framework to demonstrate that prediction accuracy can be improved by ta...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Prins, Bram. P.; Abbasi, Ali; Wong, Anson; Vaez, Ahmad; Nolte, Ilja; Franceschini, Nora; Stuart, Philip E.; Guterriez Achury, Javier; Mistry, Vanisha; Bradfield, Jonathan P.; ...
    Publisher: Public Library of Science
    Project: NIH | Identification of Psoriat... (5R01AR050511-10), NIH | INFLAMMATION: CORRELATES ... (1R01HL064753-01), NWO | Identification of relevan... (2300179771), NIH | Combined analysis of gene... (1R01AR054966-01), NIH | LINKAGE ANALYSIS OF FAMIL... (5R01AR042742-07), WT | Wellcome Trust Sanger Ins... (098051), NIH | Fine Mapping and Function... (1DP3DK085708-01), NIH | THE FRAMINGHAM HEART STUD... (N01HC025195-005), NIH | Framingham: Inflammation,... (5R01HL076784-02), NIH | Aging and Inflammation: L... (5R01AG028321-05),...

    Using genetic instruments, Behrooz Z. Alizadeh and colleagues examine the hypothesis that increased CRP levels play a causal role in common somatic and psychiatric conditions.

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Caroline S. Fox; Shih‐Jen Hwang; Kenneth Nieto; Maureen Valentino; Karen Mutalik; Joseph M. Massaro; Emelia J. Benjamin; Joanne M. Murabito;
    Publisher: John Wiley and Sons Inc.
    Project: NIH | THE FRAMINGHAM HEART STUD... (N01HC025195-005), NIH | American Heart Associatio... (3P50HL120163-03S1), NIH | Identification of common ... (5R01HL092577-02), NIH | AFGen Consortium: Atrial ... (1R01HL128914-01)

    Background New avenues of data collection such as eHealth and mobile technology have the potential to revolutionize the way large populations can be assessed and managed outside of standard research and clinical settings. Methods and Results A digital connectedness surv...

  • publication . Article . 2019
    Open Access English
    Authors:
    Lee, Yunsung; Sun, Dianjianyi; Ori, Anil P.S.; Lu, Ake T.; Seeboth, Anne; Harris, Sarah E.; Deary, Ian J.; Marioni, Riccardo E.; Sørensen, Mette; Mengel-From, Jonas; ...
    Project: NIH | Validation and optimizati... (1U01AG060908-01), RCUK | Centre for Cognitive Agei... (MR/K026992/1), EC | IDEAL (259679), NIH | THE FRAMINGHAM HEART STUD... (N01HC025195-005), NIH | OLDEST-OLD MORTALITY AND ... (5P01AG008761-08), NIH | Exceptional Aging Across ... (5R01AG029451-03), NIH | Childhood Growth, Biologi... (1R03AG060619-01), NIH | Telomeres and Female Fecu... (5R01HL134840-02), NIH | EVOLUTION OF CARDIOVASCUL... (5R01AG016592-11)

    <p>Telomere length is associated with age-related diseases and is highly heritable. It is unclear, however, to what extent epigenetic modifications are associated with leukocyte telomere length (LTL). In this study, we conducted a large-scale epigenome-wide association ...

  • publication . Article . 2018
    Open Access English
    Authors:
    Tully, P.J.; Turnbull, D.A.; Anstey, K.J.; Beckett, N.; Beiser, A.S.; Birns, J.; Brickman, A.M.; Burns, N.R.; Cosh, S.; Leeuw, de, P.W.; ...
    Publisher: BioMed Central
    Project: NIH | CHARGE: Identifying Risk ... (5U01AG049505-02), NIH | Preclinical AD: Correlate... (5R01AG049607-05), NHMRC | Evidence based mental hea... (1053578), NIH | ADSP Follow-up in Multi-E... (1U01AG052409-01), NIH | Temporal Trends, Novel Im... (3R01AG054076-02S1), NIH | THE FRAMINGHAM HEART STUD... (N01HC025195-005), NIH | PRECURSORS OF STROKE INCI... (5R01NS017950-05), NHMRC | Research to Reduce Cognit... (1102694), NIH | Microglial, Inflammatory ... (5UH2NS100605-02)

    Background A body of empirical work demonstrates that wide fluctuations in a person’s blood pressure across consecutive measures, known as blood pressure variability (BPV), hold prognostic value to predict stroke and transient ischemic attack. However, the magnitude of ...

416 research outcomes, page 2 of 42
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