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187 research outcomes, page 5 of 19
  • publication . Article . 2018
    Open Access English
    Authors:
    Amar Dhand; W. T. Longstreth; Paulo H. M. Chaves; Mandip S. Dhamoon;
    Publisher: John Wiley and Sons Inc.
    Project: NIH | Exceptional aging: 12 yea... (5R01AG023629-03), NIH | CHS research resources fo... (3U01HL130114-03S1), NIH | CORONARY HEART DISEASE AN... (N01HC085079-023), NIH | CENTRAL BLOOD ANALYSIS LA... (N01HC085086-019), NIH | CHS Events Follow-up Stud... (1U01HL080295-01), NIH | Impact of Social Network ... (7K23HD083489-02), NIH | CORONARY HEART DISEASE AN... (N01HC085082-024), NIH | CORONARY HEART DISEASE &S... (N01HC085080-018), NIH | CORONARY HEART DISEASE &S... (N01HC085083-021), NIH | CHS-Transition Phase -268... (N01HC055222-001),...

    Background Changes in social networks are rarely examined before and after various diseases because of insufficient data. CHS (The Cardiovascular Health Study) offers an opportunity to compare social network trajectories surrounding well‐adjudicated myocardial infarctio...

  • publication . Article . 2009
    Open Access English
    Authors:
    Dan E. Arking; Amit Khera; Chao Xing; W. H. Linda Kao; Wendy Post; Eric Boerwinkle; Aravinda Chakravarti;
    Publisher: Public Library of Science
    Project: NIH | CCSP - FIELD CENTER (N01HC055020-003), NIH | CORONARY HEART DISEASE AN... (N01HC085079-023), NIH | CHS-ULTRASOUND READING (N01HC045133-004), NIH | GENERAL CLINICAL RESEARCH... (5M01RR000633-31), NIH | MRI READING CENTER FOR TH... (N01HC015103-007), NIH | CENTRAL BLOOD ANALYSIS LA... (N01HC085086-019), NIH | CHS Events Follow-up Stud... (1U01HL080295-01), NIH | CARDIOVASCULAR HEALTH STU... (N01HC035129-010), NIH | CHS RETINAL READING CENTE... (N01HC075150-001), NIH | COMMUNITY AND COHORT SURV... (N01HC055015-028),...

    Extremes of electrocardiographic QT interval are associated with increased risk for sudden cardiac death (SCD); thus, identification and characterization of genetic variants that modulate QT interval may elucidate the underlying etiology of SCD. Previous studies have re...

  • publication . Article . 2013
    Open Access English
    Authors:
    Morrison, Alanna C.; Voorman, Arend; Johnson, Andrew D.; Liu, Xiaoming; Yu, Jin; Li, Alexander; Muzny, Donna; Yu, Fuli; Rice, Kenneth; Zhu, Chengsong; ...
    Project: NIH | MRI READING CENTER FOR TH... (N01HC015103-007), NIH | CHARGE consortium: gene d... (2R01HL105756-07), NIH | CHS-ULTRASOUND READING (N01HC045133-004), NIH | Hormonal trajectories in ... (5R01AG027058-04), NIH | THE FRAMINGHAM HEART STUD... (N01HC025195-005), NIH | CORONARY HEART DISEASE AN... (N01HC085079-023), NIH | Alzheimers Disease in Mil... (5R01AG020098-05), NIH | Building on GWAS for NHLB... (1RC2HL102419-01), NIH | CHS-Transition Phase -268... (N01HC055222-001), NIH | CENTRAL BLOOD ANALYSIS LA... (N01HC085086-019),...

    We describe initial steps for interrogating whole genome sequence (WGS) data to characterize the genetic architecture of a complex trait, such as high density lipoprotein cholesterol (HDL-C). We estimate that common variation contributes more to HDL-C heritability than ...

  • publication . Article . 2020
    Open Access
    Authors:
    Kulminski, Alexander M.; Shu, Leonardo; Loika, Yury; He, Liang; Nazarian, Alireza; Arbeev, Konstantin; Ukraintseva, Svetlana; Yashin, Anatoliy; Culminskaya, Irina;
    Publisher: Wiley
    Project: NIH | MRI READING CENTER FOR TH... (N01HC015103-007), NIH | Health and Retirement Stu... (3U01AG009740-24S2), NIH | Exceptional aging: 12 yea... (5R01AG023629-03), NIH | THE FRAMINGHAM HEART STUD... (N01HC025195-005), NIH | Expanding a National Reso... (3RC4AG039029-01S1), NIH | Life Course and Genetic a... (5R01AG047310-04), NIH | CTSA INFRASTRUCTURE FOR A... (1UL1RR033176-01), NIH | CHS-ULTRASOUND READING (N01HC045133-004), NIH | EPIDEMIOLOGY OF DEMENTIA ... (5R01AG008122-04), NIH | CORONARY HEART DISEASE AN... (N01HC085079-023),...

    Abstract Introduction Apolipoprotein E (APOE) ε2 and ε4 alleles encoded by rs7412 and rs429358 polymorphisms, respectively, are landmark contra and pro “risk” factors for Alzheimer's disease (AD). Methods We examined differences in linkage disequilibrium (LD) structures...

  • publication . Article . Other literature type . 2019
    Open Access
    Authors:
    Pollack, Samuela; Igo, Robert P.; Jensen, Richard A.; Christiansen, Mark; Li, Xiaohui; Cheng, Ching-Yu; Ng, Maggie C.Y.; Smith, Albert V.; Rossin, Elizabeth J.; Segrè, Ayellet V.; ...
    Publisher: eScholarship, University of California
    Project: WT | Characterising causal all... (098381), NIH | SUBCLINICAL CARDIOVASCULA... (N01HC095166-002), NIH | SUBCLINICAL CARDIOVASCULA... (N01HC095167-000), NIH | Role of Leukocyte-endothe... (5R01EY023644-02), NHMRC | Genes and Environment in ... (512423), NIH | SUBCLINICAL CARDIOVASCULA... (N01HC095160-000), NIH | Exceptional aging: 12 yea... (5R01AG023629-03), NIH | Harvard-Vision Clinical S... (1K12EY016335-01), NIH | DIABETIC AND NONDIABETIC ... (5U01DK057304-03), NHMRC | Uncovering the aetiology ... (529912),...

    <p>To identify genetic variants associated with diabetic retinopathy (DR), we performed a large, multiethnic genome-wide association study (GWAS). Discovery included eight European cohorts (n = 3,246) and seven African American cohorts (n = 2,611). We meta-analyzed acro...

  • publication . Article . 2018
    Open Access English
    Authors:
    Seyerle, A A; Sitlani, C M; Noordam, R; Gogarten, S M; Li, J; Li, X; Evans, D S; Sun, F; Laaksonen, M A; Isaacs, A; ...
    Project: NIH | GWAS of Hormone Treatment... (1U01HG005152-01), NIH | DYNAMICS OF HEALTH, AGING... (N01AG062103-011), NIH | CORONARY HEART DISEASE AN... (N01HC085079-023), NIH | THE FRAMINGHAM HEART STUD... (N01HC025195-005), NIH | Genome-Wide Association f... (5R01HL087641-02), NIH | CTSA INFRASTRUCTURE FOR A... (1UL1RR033176-01), NIH | CHARGE consortium: gene d... (2R01HL105756-07), NIH | CANCER EPIDEMIOLOGY (5T32CA009001-17), NIH | Cardiovascular Disease Ep... (5T32HL007779-25), NIH | CHS research resources fo... (3U01HL130114-03S1),...

    Thiazide diuretics, commonly used antihypertensives, may cause QT interval (QT) prolongation, a risk factor for highly fatal and difficult to predict ventricular arrhythmias. We examined whether common single-nucleotide polymorphisms (SNPs) modified the association betw...

  • publication . Article . 2017
    Open Access English
    Authors:
    Weng, Lu-Chen; Lunetta, Kathryn L.; Müller-Nurasyid, Martina; Smith, Albert Vernon; Thériault, Sébastien; Weeke, Peter E.; Barnard, John; Bis, Joshua C.; Lyytikäinen, Leo-Pekka; Kleber, Marcus E.; ...
    Project: NIH | Atrial Fibrillation: Brid... (4K23HL114724-04), NWO | NCHA Subsidiebesluit 2008... (2300155116), NIH | SUBCLINICAL CARDIOVASCULA... (N01HC095168-000), NIH | CORONARY HEART DISEASE AN... (N01HC085079-023), NIH | SUBCLINICAL CARDIOVASCULA... (N01HC095166-002), NIH | A Genome-Wide Association... (5R01HL086694-05), NIH | SUBCLINICAL CARDIOVASCULA... (N01HC095163-000), NIH | GWA for Gene-Environment ... (5U01HG004402-02), NIH | WGA Study to Identify Gen... (5R01HL087652-03), NIH | SUBCLINICAL CARDIOVASCULA... (N01HC095167-000),...

    This work is funded by the European Commision’s Horizon 2020 research and innovation programme (grant number 633196: CATCH ME to Dr. Sinner). AGES: The Age, Gene/Environment Susceptibility Reykjavik Study is funded by NIH contract N01-AG-12100. ARIC: The Atherosclerosis...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Lubitz, Steven A.; Brody, Jennifer A.; Bihlmeyer, Nathan A.; Roselli, Carolina; Weng, Lu-Chen; Christophersen, Ingrid E.; Alonso, Alvaro; Boerwinkle, Eric; Gibbs, Richard A.; Bis, Joshua C.; ...
    Publisher: Public Library of Science
    Project: NIH | CORONARY HEART DISEASE AN... (N01HC085079-023), NIH | Human Exome Sequencing in... (1RC2HL103010-01), NIH | CHARGE consortium: gene d... (2R01HL105756-07), NIH | THE FRAMINGHAM HEART STUD... (N01HC025195-005), NIH | Comprehensive Sequencing ... (1RC2HL102925-01), NIH | Exceptional aging: 12 yea... (5R01AG023629-03), NIH | Prospective meta-analyses... (1R01HL103612-01A1), NIH | CENTRAL BLOOD ANALYSIS LA... (N01HC085086-019), NIH | CHS Events Follow-up Stud... (1U01HL080295-01), NIH | Patterns of Health Care U... (5R01HL102214-03),...

    Atrial fibrillation (AF) is a morbid and heritable arrhythmia. Over 35 genes have been reported to underlie AF, most of which were described in small candidate gene association studies. Replication remains lacking for most, and therefore the contribution of coding varia...

  • publication . Article . 2014
    Open Access English
    Authors:
    Morrison, Alanna C.; Bis, Joshua C.; Hwang, Shih-Jen; Ehret, Georg B.; Lumley, Thomas; Rice, Kenneth; Muzny, Donna; Gibbs, Richard A.; Boerwinkle, Eric; Psaty, Bruce M.; ...
    Project: NIH | Hormonal trajectories in ... (5R01AG027058-04), NIH | THE FRAMINGHAM HEART STUD... (N01HC025195-005), NIH | MRI READING CENTER FOR TH... (N01HC015103-007), NIH | CORONARY HEART DISEASE AN... (N01HC085085-006), NIH | CORONARY HEART DISEASE AN... (N01HC085082-024), NIH | CHARGE consortium: gene d... (2R01HL105756-07), NIH | CHS-ULTRASOUND READING (N01HC045133-004), NIH | CORONARY HEART DISEASE AN... (N01HC085079-023), NIH | CORONARY HEART DISEASE AN... (N01HC085084-005), NIH | CORONARY HEART DISEASE &S... (N01HC085081-016),...

    Background Genome-wide association studies (GWAS) identified multiple loci for blood pressure (BP) and hypertension. Six genes – ATP2B1, CACNB2, CYP17A1, JAG1, PLEKHA7, and SH2B3 – were evaluated for sequence variation with large effects on systolic blood pressure (SBP)...

  • publication . Article . 2019
    Open Access English
    Authors:
    Evans, S; McRae-McKee, K; Hadjichrysanthou, C; Wong, MM; Ames, D; Lopez, O; De Wolf, F; Anderson, RM; Australian Imaging Biomarkers and Lifestyle flagship study of ageing; Predictors of Cognitive Decline Among Normal Individuals (BIOCARD) study; ...
    Publisher: Elsevier
    Project: NIH | Alzheimers Disease in Mil... (5R01AG020098-05), CIHR , NIH | A Proteogenomic Approach ... (2P50AG025688-11), NIH | Exceptional aging: 12 yea... (5R01AG023629-03), NIH | EDUCATION AND INFORMATION... (2P30AG008017-21), NIH | Role of LRP &its ligand t... (5P50AG005681-19), NIH | THE FRAMINGHAM HEART STUD... (N01HC025195-005), NIH | ALZHEIMERS DISEASE RESEAR... (5P50AG005136-21), NIH | CORONARY HEART DISEASE AN... (N01HC085079-023), NIH | UCLA Alzheimers Disease R... (3P50AG016570-07S1),...

    There exist a large number of cohort studies that have been used to identify genetic and biological risk factors for developing Alzheimer's disease (AD). However, there is a disagreement between studies as to how strongly these risk factors affect the rate of progressio...

187 research outcomes, page 5 of 19
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