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187 research outcomes, page 3 of 19
  • publication . Article . 2018
    Open Access English
    Authors:
    Beecham, Gary W.; Vardarajan, Badri; Blue, Elizabeth; Bush, William; Jaworski, James; Barral, Sandra; DeStefano, Anita; Hamilton-Nelson, Kara; Kunkle, Brian; Martin, Eden R.; ...
    Publisher: Wolters Kluwer
    Project: EC | ENGAGE (201413), NIH | Sequence-based Discovery ... (5U01AG049507-03), NIH | Genomic Convergence in Al... (1R01AG027944-01A2), NIH | Data Management Core (5U10AA008401-27), NIH | COGNITIVE TESTS, APOE, BR... (1R01AG015928-01), NWO | Dissecting genetic comple... (2300137747), NIH | Impact of coding and non-... (5UG3NS104095-02), NIH | CHARGE consortium: gene d... (2R01HL105756-07), NIH | CHARGE: Identifying Risk ... (5U01AG049505-02), NIH | Consortium for Alzheimers... (1UF1AG047133-01),...

    Objective To identify genetic variation influencing late-onset Alzheimer disease (LOAD), we used a large data set of non-Hispanic white (NHW) extended families multiply-affected by LOAD by performing whole genome sequencing (WGS). Methods As part of the Alzheimer Diseas...

  • publication . Preprint . Other literature type . 2019
    Open Access English
    Authors:
    Zhao, Di; Bartz, Traci M.; Sotoodehnia, Nona; Post, Wendy S.; Heckbert, Susan R.; Alonso, Alvaro; Longchamps, Ryan J.; Castellani, Christina A.; Hong, Yun Soo; Rotter, Jerome I.; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | CORONARY HEART DISEASE AN... (N01HC085079-023), NIH | Older Americans Independe... (3P30AG021334-01S1), NIH | UCLA Clinical Translation... (3UL1TR001881-01S2), NIH | SUBCLINICAL CARDIOVASCULA... (N01HC095167-000), NIH | CHS research resources fo... (3U01HL130114-03S1), NIH | CHARGE consortium: gene d... (2R01HL105756-07), NIH | Exceptional aging: 12 yea... (5R01AG023629-03), NIH | SUBCLINICAL CARDIOVASCULA... (N01HC095161-000), NIH | Atrial fibrillation burde... (5R01HL127659-03), NIH | Genomics of Cardiac Elect... (4R01HL116747-04),...

    <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Mechanistic studies suggests that mitochondria DNA (mtDNA) dysfunction may be associated with increased risk of atrial fibrillation (AF). The association between mtDNA copy number (mtD...

  • publication . Article . 2018
    Open Access
    Authors:
    Avery, Christy L.; He, Qianchuan; North, Kari E.; Ambite, Jose L.; Boerwinkle, Eric; Fornage, Myriam; Hindorff, Lucia A.; Kooperberg, Charles; Meigs, James B.; Pankow, James S.; ...
    Publisher: Public Library of Science (PLoS)
    Project: NIH | SUBCLINICAL CARDIOVASCULA... (N01HC095160-000), NIH | SUBCLINICAL CARDIOVASCULA... (N01HC095166-002), NIH | CARDIA-ECHOCARDIOGRAPHY R... (N01HC095100-003), NIH | MRI READING CENTER FOR TH... (N01HC015103-007), NIH | CORONARY HEART DISEASE RI... (N01HC048047-022), NIH | THE FRAMINGHAM HEART STUD... (N01HC025195-005), NIH | SUBCLINICAL CARDIOVASCULA... (N01HC095161-000), NIH | SUBCLINICAL CARDIOVASCULA... (N01HC095167-000), NIH | CCSP - FIELD CENTER (N01HC055020-003), NIH | Genetic Epidemiology of C... (3U01HG004803-02S1),...

    Author Summary The metabolic syndrome represents a clustering of metabolic phenotypes (e.g. elevated blood pressure, cholesterol levels, and plasma glucose, as well as abdominal obesity) and is associated with an increased risk of atherosclerosis and type 2 diabetes. Al...

  • publication . Article . 2018
    Open Access English
    Authors:
    Lopez, Lorna M.; Hill, W. David; Harris, Sarah E.; Valdes Hernandez, Maria; Munoz Maniega, Susana; Bastin, Mark E.; Bailey, Emma; Smith, Colin; McBride, Martin; McClure, John; ...
    Project: NIH | MRI READING CENTER FOR TH... (N01HC015103-007), NIH | Epidemiology of Venous Th... (5R01HL059367-10), NIH | Genome-Wide Association f... (5R01HL087641-02), NIH | CTSA INFRASTRUCTURE FOR A... (1UL1RR033176-01), NIH | A Genome-Wide Association... (5R01HL093029-02), FWF | Genetics of Cerebral Smal... (P 20545), NIH | CHS-ULTRASOUND READING (N01HC045133-004), NIH | EPIDEMIOLOGY OF DEMENTIA ... (5R01AG008122-04), NIH | THE FRAMINGHAM HEART STUD... (N01HC025195-005), NIH | UCLA Clinical and Transla... (5UL1TR000124-04),...

    Background and Purpose— White matter hyperintensities (WMH) of presumed vascular origin increase the risk of stroke and dementia. Despite strong WMH heritability, few gene associations have been identified. Relevant experimental models may be informative. Methods— We te...

  • publication . Article . 2017
    Open Access English
    Authors:
    Fernández, Maria Victoria; Kim, Jong Hun; Budde, John P.; Black, Kathleen; Medvedeva, Alexandra; Saef, Ben; Deming, Yuetiva; Del-Aguila, Jorge; Ibañez, Laura; Dube, Umber; ...
    Publisher: Public Library of Science
    Project: NIH | Large Scale Genome Sequen... (3U54HG003079-03S1), NIH | Alzheimers Disease in Mil... (5R01AG020098-05), NIH | CHARGE: Identifying Risk ... (5U01AG049505-02), NIH | Consortium for Alzheimers... (1UF1AG047133-01), NIH | Sequence-based Discovery ... (5U01AG049507-03), NIH | Role of LRP &its ligand t... (5P50AG005681-19), NIH | Collaborative GWAS of Dem... (1R01AG033193-01), NIH | CORONARY HEART DISEASE AN... (N01HC085079-023), NIH | Coordinating Center for G... (3U54AG052427-03S1), NIH | CHS research resources fo... (3U01HL130114-03S1),...

    Author summary In this study we provide further genetic evidence of the clinical, pathological and molecular overlap between neurodegenerative diseases. We screened the known Mendelian genes in Alzheimer disease (AD), Frontotemporal Dementia (FTD), Parkinson disease (PD...

  • publication . Article . 2015
    Open Access English
    Authors:
    Hansen, JG; Gao, W; Dupuis, J; O’Connor, GT; Tang, W; Kowgier, M; Sood, A; Gharib, SA; Palmer, LJ; Fornage, M; ...
    Publisher: Springer Nature
    Project: NIH | Genes of the CYP450-Deriv... (5R01HL084099-04), NIH | Discovering Pathways of F... (5RC1AG035835-02), NIH | CORONARY HEART DISEASE RI... (N01HC048047-022), NIH | THE FRAMINGHAM HEART STUD... (N01HC025195-005), NIH | CORONARY ARTERY DISEASE R... (N01HC095095-028), NIH | CHARGE consortium: gene d... (2R01HL105756-07), NIH | STUDY CORONARY HEART DISE... (N01HC048048-002), NIH | CORONARY HEART DISEASE AN... (N01HC085079-023), NIH | GWAS of longitudinal bloo... (1U01HG004729-01), NIH | Genome Wide Association C... (5U01HG004446-04),...

    Background Vitamin D is associated with lung function in cross-sectional studies, and vitamin D inadequacy is hypothesized to play a role in the pathogenesis of chronic obstructive pulmonary disease. Further data are needed to clarify the relation between vitamin D stat...

  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Wild, Philipp S.; Felix, Janine F.; Schillert, Arne; Teumer, Alexander; Chen, Ming-Huei; Leening, Maarten J.G.; Völker, Uwe; Großmann, Vera; Brody, Jennifer A.; Irvin, Marguerite R.; ...
    Publisher: American Society for Clinical Investigation
    Project: NIH | CHARGE consortium: gene d... (2R01HL105756-07), NIH | The Family Blood Pressure... (5U01HL054471-13), NIH | Vascular Stiffness as a P... (1R01HL126136-01A1), NIH | GWAS of longitudinal bloo... (1U01HG004729-01), NIH | THE FRAMINGHAM HEART STUD... (N01HC025195-005), FWF | Genetics of Cerebral Smal... (P 20545), NIH | Exceptional aging: 12 yea... (5R01AG023629-03), NIH | Myocardial and Arterial A... (5R00HL107642-05), NWO | NCHA Subsidiebesluit 2008... (2300155116), NIH | WGA Study to Identify Gen... (5R01HL087652-03),...

    BACKGROUND: Understanding the genetic architecture of cardiac structure and function may help to prevent and treat heart disease. This investigation sought to identify common genetic variations associated with inter-individual variability in cardiac structure and functi...

  • publication . Article . 2012
    Open Access
    Authors:
    Avery, CL; Sethupathy, P; Buyske, S; He, Q; Lin, DY; Arking, DE; Carty, CL; Duggan, D; Fesinmeyer, MD; Hindorff, LA; ...
    Publisher: Public Library of Science (PLoS)
    Project: NIH | CARDIOVASCULAR EVALUATION... (5U01HL065521-02), NIH | CORONARY HEART DISEASE AN... (N01HC085079-023), NIH | CORONARY HEART DISEASE RI... (N01HC048047-022), NIH | CARDIA-ECHOCARDIOGRAPHY R... (N01HC045134-001), NIH | WGA Study to Identify Gen... (5R01HL087652-03), NIH | Epidemiology of putative ... (5U01HG004790-04), NIH | CCSP - FIELD CENTER AND U... (N01HC055018-017), NIH | CARDIOVASCULAR DISEASE IN... (5U01HL041652-10), NIH | CENTRAL BLOOD ANALYSIS LA... (N01HC085086-019), NIH | CHS Events Follow-up Stud... (1U01HL080295-01),...

    The QT interval (QT) is heritable and its prolongation is a risk factor for ventricular tachyarrhythmias and sudden death. Most genetic studies of QT have examined European ancestral populations; however, the increased genetic diversity in African Americans provides opp...

  • publication . Article . Other literature type . 2012
    Open Access
    Authors:
    Patel, Sanjay R.; Goodloe, Robert; De, Gourab; Kowgier, Matthew; Weng, Jia; Buxbaum, Sarah G.; Cade, Brian; Fulop, Tibor; Gharib, Sina A.; Gottlieb, Daniel J.; ...
    Publisher: Public Library of Science (PLoS)
    Project: NIH | Epidemiology of Venous Th... (5R01HL059367-10), NIH | CORONARY HEART DISEASE AN... (N01HC085079-023), NIH | MRI READING CENTER FOR TH... (N01HC015103-007), NIH | The Genetics of Metabolic... (5K08HL081385-05), NIH | A Genome-Wide Association... (5R01HL086694-05), NIH | GWA for Gene-Environment ... (5U01HG004402-02), NIH | Obesity and Dietary Pathw... (5U54CA116867-05), NIH | Familial Aggregation and ... (3R01HL046380-12S1), NIH | CHS-ULTRASOUND READING (N01HC045133-004), NIH | CHS-Transition Phase -268... (N01HC055222-001),...

    Although obstructive sleep apnea (OSA) is known to have a strong familial basis, no genetic polymorphisms influencing apnea risk have been identified in cross-cohort analyses. We utilized the National Heart, Lung, and Blood Institute (NHLBI) Candidate Gene Association R...

  • publication . Article . Other literature type . 2018
    Open Access
    Authors:
    Wang, Henry E.; Donnelly, John P.; Yende, Sachin; Levitan, Emily B.; Shapiro, Nathan I.; Dai, Yuling; Zhao, Hong; Heiss, Gerardo; Odden, Michelle; Newman, Anne; ...
    Publisher: MDPI AG
    Project: NIH | CORONARY HEART DISEASE &S... (N01HC085081-016), NIH | Immunosuppression and Ris... (1F31GM122180-01), NIH | UAB Center for Clinical a... (3UL1RR025777-01S1), NIH | CORONARY HEART DISEASE AN... (N01HC085079-023), NIH | CORONARY HEART DISEASE AN... (N01HC085082-024), NIH | Exceptional aging: 12 yea... (5R01AG023629-03), NIH | CORONARY HEART DISEASE &S... (N01HC085083-021), NIH | CHS-Transition Phase -268... (N01HC055222-001), NIH | CHS research resources fo... (3U01HL130114-03S1), NIH | CORONARY HEART DISEASE &S... (N01HC085080-018),...

    16), CHS 10 (IQR 6&ndash

187 research outcomes, page 3 of 19
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