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1,192 research outcomes, page 5 of 120
  • publication . Article . 2018
    Open Access
    Authors:
    Grimbert, Stéphanie; Vargas Velazquez, Amhed Missael; Braendle, Christian;
    Publisher: Genetics Society of America
    Project: NIH | Caenorhabditis Genetics C... (1P40OD010440-01)

    Studying how molecular pathways respond to ecologically relevant environmental variation is fundamental to understand organismal development and its evolution. Here we characterize how starvation modulates Caenorhabditis elegans vulval cell fate patterning – an environm...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Richardson, Claire E.; Yee, Callista; Shen, Kang;
    Publisher: Public Library of Science (PLoS)
    Project: NIH | Dopamine modulation of sy... (5R01NS091144-02), NIH | Dopamine Degradation Path... (1R01NS103037-01A1), NIH | Caenorhabditis Genetics C... (1P40OD010440-01)

    Neurons have a lifespan that parallels that of the organism and are largely irreplaceable. Their unusually long lifespan predisposes neurons to neurodegenerative disease. We sought to identify physiological mechanisms that delay neuron aging in Caenorhabditis elegans by...

  • publication . Article . Other literature type . 2014
    Open Access
    Authors:
    Benjamin P Weaver; Rebecca Zabinsky; Yi M Weaver; Eui Seung Lee; Ding Xue; Min Han;
    Publisher: eLife Sciences Publications, Ltd
    Project: NIH | Training in Signaling and... (2T32GM008759-11), NIH | GENES REGULATING RAS/MAP ... (3R01GM047869-04S1), NIH | Caenorhabditis Genetics C... (1P40OD010440-01), NIH | TARGETS OF THE CELL DEATH... (1R01GM059083-01)

    Genetic redundancy and pleiotropism have limited the discovery of functions associated with miRNAs and other regulatory mechanisms. To overcome this, we performed an enhancer screen for developmental defects caused by compromising both global miRISC function and individ...

  • publication . Article . 2017
    Open Access
    Authors:
    Devkota, Ranjan; Svensk, Emma; Ruiz, Mario; Ståhlman, Marcus; Borén, Jan; Pilon, Marc;
    Publisher: Public Library of Science (PLoS)
    Project: NIH | Caenorhabditis Genetics C... (1P40OD010440-01)

    Dietary fatty acids can be incorporated directly into phospholipids. This poses a specific challenge to cellular membranes since their composition, hence properties, could greatly vary with different diets. That vast variations in diets are tolerated therefore implies t...

  • publication . Article . Other literature type . Preprint . 2018
    Open Access English
    Authors:
    Partridge, Frederick A.; Brown, Anwen E.; Buckingham, Steven D.; Willis, Nicky J.; Wynne, Graham M.; Forman, Ruth; Else, Kathryn J.; Morrison, Alison A.; Matthews, Jacqueline B.; Russell, Angela J.; ...
    Project: NIH | Caenorhabditis Genetics C... (1P40OD010440-01)

    Parasitic nematodes infect hundreds of millions of people and farmed livestock. Further, plant parasitic nematodes result in major crop damage. The pipeline of therapeutic compounds is limited and parasite resistance to the existing anthelmintic compounds is a global th...

  • publication . Article . 2015
    Open Access English
    Authors:
    Aimee Jaramillo-Lambert; Abigail S. Fuchsman; Amy S. Fabritius; Harold E. Smith; Andy Golden;
    Publisher: Genetics Society of America
    Project: NIH | Caenorhabditis Genetics C... (1P40OD010440-01)

    The production of viable embryos requires the coordination of many cellular processes, including protein synthesis, cytoskeletal reorganization, establishment of polarity, cell migration, cell division, and in Caenorhabditis elegans, eggshell formation. Defects in any o...

  • publication . Preprint . 2019
    Open Access
    Authors:
    Rahman, Mizanur; Edwards, Hunter; Birze, Nikolajs; Gabrilska, Rebecca; Rumbaugh, Kendra P.; Blawzdziewicz, Jerzy; Szewczyk, Nathaniel J.; Driscoll, Monica; Vanapalli, Siva A.;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | A Strength Analysis Tool ... (5R21AG050503-02), NSF | CAREER:Collective hydrody... (1150836), NIH | Genetic Dissection of Mec... (5R01AG051995-03), NIH | Caenorhabditis Genetics C... (1P40OD010440-01)

    <jats:title>Abstract</jats:title><jats:p><jats:italic>Caenorhabditis elegans</jats:italic> is a powerful animal model in aging research. Standard longevity assays on agar plates involve the tedious task of picking and transferring animals to prevent younger progeny from...

  • publication . Article . 2016
    Open Access
    Authors:
    Abdulhameed Khan;
    Publisher: Elsevier BV
    Project: FWF | The role of specialized r... (I 2514), NIH | Caenorhabditis Genetics C... (1P40OD010440-01), FWF | ATM dependent phosphoryla... (P 24498)

    Summary Aging is accompanied by loss of subcutaneous adipose tissue. This may be due to reduced differentiation capacity or deficiency in DNA damage repair (DDR) factors. Here we investigated the role of SNEVhPrp19/hPso4, which was implicated in DDR and senescence evasi...

  • publication . Article . Other literature type . 2014
    Open Access English
    Authors:
    Nagy, Stanislav; Tramm, Nora; Sanders, Jarred; Iwanir, Shachar; Shirley, Ian A; Levine, Erel; Biron, David;
    Publisher: eLife Sciences Publications, Ltd
    Project: NSF | Graduate Research Fellows... (0638477), NIH | Caenorhabditis Genetics C... (1P40OD010440-01), NSF | The first analysis of the... (1256989)

    Biological homeostasis invokes modulatory responses aimed at stabilizing internal conditions. Using tunable photo- and mechano-stimulation, we identified two distinct categories of homeostatic responses during the sleep-like state of Caenorhabditis elegans (lethargus). ...

  • publication . Article . Other literature type . Preprint . 2018
    Open Access
    Authors:
    Bezler, Alexandra; Braukmann, Fabian; West, Sean M.; Duplan, Arthur; Conconi, Raffaella; Schütz, Frédéric; Gönczy, Pierre; Piano, Fabio; Gunsalus, Kristin; Miska, Eric A.; ...
    Publisher: Public Library of Science (PLoS)
    Project: WT | Transgenerational epigene... (104640), NIH | A systematic RNAi-based m... (1R01HD046236-01), NIH | Caenorhabditis Genetics C... (1P40OD010440-01), WT | Core support for the Well... (092096), NIH | Using Sequence and Struct... (5F32GM100614-02), NIH | Encyclopedia of C elegans... (3U01HG004276-03S1)

    Author summary Environmental factors such as heat or pathogens influence living organisms, and in some cases these experiences can be passed on to the next generation. One such environmental factor is double stranded RNA that can be taken up by some animals and induce c...

1,192 research outcomes, page 5 of 120
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