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1,192 research outcomes, page 4 of 120
  • publication . Article . 2018
    Open Access English
    Authors:
    Hiroshi Qadota; Yohei Matsunaga; Pritha Bagchi; Karen I. Lange; Karma J. Carrier; William Vander Pols; Emily Swartzbaugh; Kristy J. Wilson; Martin Srayko; David C. Pallas; ...
    Publisher: The American Society for Cell Biology
    Project: NIH | Caenorhabditis Genetics C... (1P40OD010440-01), NIH | Role of UNC-89 (obscurin)... (5R01AR064307-05), NIH | Cellular Targets of Polyo... (5R01CA057327-17)

    <jats:p> Protein phosphatase 2A (PP2A) is a heterotrimer composed of single catalytic and scaffolding subunits and one of several possible regulatory subunits. We identified PPTR-2, a regulatory subunit of PP2A, as a binding partner for the giant muscle protein UNC-89 (...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Jesse Cohn; Vivek Dwivedi; Giulio Valperga; Nicole Zarate; Mario de Bono; H. Robert Horvitz; Jonathan T. Pierce;
    Publisher: Genetics Society of America
    Project: NIH | Caenorhabditis Genetics C... (1P40OD010440-01), NIH | High-speed opto-fluidics ... (5R01AG041135-05), NIH | Synergistic patterned neu... (1RF1AG057355-01)

    The BH3-only family of proteins is key for initiating apoptosis in a variety of contexts, and may also contribute to non-apoptotic cellular processes. Historically, the nematode Caenorhabditis elegans has provided a powerful system for studying and identifying conserved...

  • publication . Preprint . Other literature type . 2019
    Open Access English
    Authors:
    Park, Jaeseok; Meisel, Joshua D; Kim, Dennis H;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Caenorhabditis Genetics C... (1P40OD010440-01), NIH | Molecular Genetics of Inn... (1R01GM084477-01)

    <jats:title>Abstract</jats:title><jats:p>Dynamic gene expression in neurons shapes fundamental processes of the nervous systems of animals. But how different stimuli that activate the same neuron can lead to distinct transcriptional responses remains unclear. We have be...

  • publication . Article . 2017
    Open Access English
    Authors:
    Gokce, Sertan Kutal; Hegarty, Evan Marley; Mondal, Sudip; Zhao, Peisen; Ghorashian, Navid; Hilliard, Massimo A.; Ben-Yakar, Adela;
    Publisher: Nature Publishing Group
    Project: NIH | High-speed opto-fluidics ... (5R01AG041135-05), NIH | Microfluidic-microtiter i... (5R21NS067340-02), NIH | Caenorhabditis Genetics C... (1P40OD010440-01), NIH | Integrated Microfluidics ... (1R21NS058646-01)

    Abstract Several sophisticated microfluidic devices have recently been proposed for femtosecond laser axotomy in the nematode C. elegans for immobilization of the animals for surgery to overcome time-consuming and labor-intensive manual processes. However, nerve regener...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Alcántar-Fernández, Jonathan; Navarro, Rosa E.; Salazar-Martínez, Ana María; Pérez-Andrade, Martha Elva; Miranda-Ríos, Juan;
    Publisher: Public Library of Science
    Project: NIH | Caenorhabditis Genetics C... (1P40OD010440-01)

    High-glycemic-index diets, as well as a sedentary lifestyle are considered as determinant factors for the development of obesity, type 2 diabetes, and cardiovascular diseases in humans. These diets have been shown to shorten the life span of C. elegans in a manner that ...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Patricia Kreis; Christian Gallrein; Eugenia Rojas-Puente; Till G. A. Mack; Cristina Kroon; Viktor Dinkel; Claudia Willmes; Kai Murk; Susanne tom-Dieck; Erin M. Schuman; ...
    Publisher: Nature Publishing Group UK
    Project: NIH | Caenorhabditis Genetics C... (1P40OD010440-01)

    Drebrin is an actin-binding protein known to play a role in neuronal dendritic spines but its precise regulation is unclear. Here, the authors report that DBN is activated by oxidative stress in an ATM-kinase dependent manner and increases resistance to oxidative stress...

  • publication . Article . 2016
    Open Access English
    Authors:
    Visscher, Marieke; De Henau, Sasha; Wildschut, Mattheus H E; van Es, Robert J. J.; Dhondt, Ineke; Michels, Helen; Kemmeren, Patrick; Nollen, Ellen A; Braeckman, Bart P; Burgering, Boudewijn M T; ...
    Publisher: Elsevier
    Project: NIH | Caenorhabditis Genetics C... (1P40OD010440-01)

    SummaryThe balance between protein synthesis and protein breakdown is a major determinant of protein homeostasis, and loss of protein homeostasis is one of the hallmarks of aging. Here we describe pulsed SILAC-based experiments to estimate proteome-wide turnover rates o...

  • publication . Article . Other literature type . 2019
    Open Access
    Authors:
    Mori, Haruka; Ashida, Keita; Shidara, Hisashi; Nikai, Tatsuya; Hotta, Kohji; Oka, Kotaro;
    Publisher: Public Library of Science (PLoS)
    Project: NIH | Caenorhabditis Genetics C... (1P40OD010440-01)

    Animals change their behaviors in response to external stimuli, and numerous neurotransmitters are involved in these behavioral changes. In Caenorhabditis elegans, serotonin (5-HT) affects various behaviors such as inhibition of locomotion, stimulation of egg laying, an...

  • publication . Article . 2015
    Open Access English
    Authors:
    Lorenz Studer;
    Publisher: Public Library of Science
    Project: NIH | Caenorhabditis Genetics C... (1P40OD010440-01)

    Mammalian NOTCH1-4 receptors are all associated with human malignancy, although exact roles remain enigmatic. Here we employ glp-1(ar202), a temperature-sensitive gain-of-function C. elegans NOTCH mutant, to delineate NOTCH-driven tumor responses to radiotherapy. At ≤20...

  • publication . Preprint . 2017
    Open Access English
    Authors:
    Abigail R. Gerhold; Vincent Poupart; Jean-Claude Labbé; Paul S. Maddox;
    Publisher: Cold Spring Harbor Laboratory
    Project: CIHR , NIH | Caenorhabditis Genetics C... (1P40OD010440-01)

    <jats:title>Abstract</jats:title><jats:p>The spindle assembly checkpoint (SAC) is a conserved mitotic regulator that preserves genome stability. Despite its central role in preserving the fidelity of mitosis, the strength of the SAC varies widely between cell types. How...

1,192 research outcomes, page 4 of 120
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