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1,308 research outcomes, page 1 of 131
  • publication . Article . 2018
    Open Access
    Authors:
    Krzysztof Drabikowski; Jacqueline Ferralli; Michal Kistowski; Jacek Oledzki; Michal Dadlez; Ruth Chiquet-Ehrismann;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Caenorhabditis Genetics C... (1P40OD010440-01)

    Abstract Post-translational modification by small ubiquitin-related modifier (SUMO) is a key regulator of cell physiology, modulating protein-protein and protein-DNA interactions. Recently, SUMO modifications were postulated to be involved in response to various stress ...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Tesfahun Dessale Admasu; Krishna Chaithanya Batchu; Li Fang Ng; Amaury Cazenave-Gassiot; Markus R. Wenk; Jan Gruber;
    Publisher: Nature Publishing Group
    Project: NIH | Caenorhabditis Genetics C... (1P40OD010440-01)

    We report the effect of four lifespan modifying drugs and of synergistic combinations of these drugs on lipid profile in Caenorhabditis elegans. We employ ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS) to compare the abundance of lipid species...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Jia, Ray; Zhang, Jiuli; Jia, Kailiang;
    Publisher: John Wiley and Sons Inc.
    Project: NIH | The novel role of autopha... (1R15HD080497-01), NIH | Caenorhabditis Genetics C... (1P40OD010440-01)

    In environments with limited food and high population density, Caenorhabditis elegans larvae may enter the dauer stage, in which metabolism is shifted to fat accumulation to allow larvae to survive for months without food. Mutations in the insulin‐like receptor gene daf...

  • publication . Article . 2014
    Open Access English
    Authors:
    Anna Y. Zinovyeva; Samir Bouasker; Martin J. Simard; Christopher M. Hammell; Victor Ambros;
    Publisher: Public Library of Science
    Project: NIH | Genetic control of animal... (5R01GM034028-28), CIHR , NIH | Caenorhabditis Genetics C... (1P40OD010440-01)

    Author Summary microRNAs are small non-coding RNAs that function in diverse processes by post-transcriptionally regulating gene expression. Argonautes form the core of the microRNA Induced Silencing Complex (miRISC) and are required for microRNA biogenesis and function....

  • publication . Article . 2017
    Open Access English
    Authors:
    Jianhua Yin; Yaling Huang; Pengfei Guo; Siqi Hu; Sawako Yoshina; Nan Xuan; Qiwen Gan; Shohei Mitani; Chonglin Yang; Xiaochen Wang;
    Publisher: The Rockefeller University Press
    Project: NIH | Caenorhabditis Genetics C... (1P40OD010440-01)

    Rab2 regulates multiple membrane traffic processes, but how it is recruited to and activated on the target membrane remains unclear. Here, Yin et al. identify a conserved protein, GOP-1, that activates UNC-108/Rab2 to promote phagosome, endosome, and DCV maturation.

  • publication . Article . 2015
    Open Access English
    Authors:
    Ding, Gang; Zou, Wenjuan; Zhang, Hu; Xue, Yadan; Cai, Yang; Huang, Guifang; Chen, Lufeng; Duan, Shumin; Kang, Lijun;
    Publisher: Public Library of Science (PLoS)
    Project: NIH | Caenorhabditis Genetics C... (1P40OD010440-01)

    Glial cells are important components of the nervous system. However, how they respond to physiological stimuli in vivo remains largely unknown. In this study, we investigated the electrophysiological activities and Ca2+ responses of the C. elegans amphid sheath glia (AM...

  • publication . Article . 2015
    Open Access
    Authors:
    Cortes, Daniel B; McNally, Karen L; Mains, Paul E; McNally, Francis J;
    Publisher: eLife Sciences Publications, Ltd
    Project: NIH | Mechanisms of asymmetric ... (3R01GM079421-03S1), NIH | TRAINING IN MOLECULAR AND... (5T32GM007377-22), NIH | Caenorhabditis Genetics C... (1P40OD010440-01)

    Trisomy, the presence of a third copy of one chromosome, is deleterious and results in inviable or defective progeny if passed through the germ line. Random segregation of an extra chromosome is predicted to result in a high frequency of trisomic offspring from a trisom...

  • publication . Article . 2020
    Open Access
    Authors:
    Haeussler, Simon; Köhler, Fabian; Witting, Michael; Premm, Madeleine F.; Rolland, Stéphane G.; Fischer, Christian; Chauve, Laetitia; Casanueva, Olivia; Conradt, Barbara;
    Publisher: Public Library of Science (PLoS)
    Project: NIH | Caenorhabditis Genetics C... (1P40OD010440-01)

    Author summary Various quality control mechanisms within the cell ensure mitochondrial homeostasis. Specifically, mitochondrial fission and fusion, the mitochondrial unfolded protein response (UPRmt) and/or mitophagy are induced upon mitochondrial stress to maintain or ...

  • publication . Article . Other literature type . 2018
    Open Access
    Authors:
    Ow, Maria C.; Borziak, Kirill; Nichitean, Alexandra M.; Dorus, Steve; Hall, Sarah E.;
    Publisher: Public Library of Science (PLoS)
    Project: NIH | Caenorhabditis Genetics C... (1P40OD010440-01)

    Environmental stress during early development in animals can have profound effects on adult phenotypes via programmed changes in gene expression. Using the nematode C. elegans, we demonstrated previously that adults retain a cellular memory of their developmental experi...

  • publication . Article . Other literature type . 2014
    Open Access English
    Authors:
    Karen McNally; Evan Berg; Daniel B Cortes; Veronica Hernandez; Paul E Mains; Francis J McNally;
    Publisher: The American Society for Cell Biology
    Project: NIH | TRAINING IN MOLECULAR AND... (5T32GM007377-22), NIH | Caenorhabditis Genetics C... (1P40OD010440-01), NIH | Mechanisms of asymmetric ... (3R01GM079421-03S1)

    Assembly of Caenorhabditis elegans female meiotic spindles requires both MEI-1 and MEI-2 subunits of the microtubule-severing ATPase katanin. Strong loss-of-function mutants assemble apolar intersecting microtubule arrays, whereas weaker mutants assemble bipolar meiotic...

1,308 research outcomes, page 1 of 131
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