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849 research outcomes, page 1 of 85
  • publication . Article . 2019
    Open Access
    Authors:
    Zhang, Tingting; Zhao, Zanzan; Zhang, Chao; Zhang, Junjun; Jin, Zhenlan; Li, Ling;
    Publisher: Frontiers Media SA
    Project: NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), CIHR

    Using the Pearson correlation coefficient to constructing functional brain network has been evidenced to be an effective means to diagnose different stages of mild cognitive impairment (MCI) disease. In this study, we investigated the efficacy of a classification framew...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Hanseeuw, Bernard J.; Betensky, Rebecca A.; Mormino, Elizabeth C.; Schultz, Aaron P.; Sepulcre, Jorge; Becker, John A.; Jacobs, Heidi I.L.; Buckley, Rachel F.; LaPoint, Molly R.; Vannini, Patrizia; ...
    Project: NIH | Disentangling the contrib... (5R01AG046396-05), CIHR , NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), NIH | Impact of Amyloid and Tau... (3P01AG036694-09S2)

    Introduction: Amyloid positron emission tomography (PET) data are commonly expressed as binary measures of cortical deposition. However, not all individuals with high cortical amyloid will experience rapid cognitive decline. Motivated by postmortem data, we evaluated a ...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Karin Knesaurek; Geoffrey Warnock; Lale Kostakoglu; Cyrill Burger; null for Alzheimer′s Disease;
    Publisher: Wolters Kluwer Medknow Publications
    Project: NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), CIHR

    Amyloid positron emission tomography (PET) imaging with florbetapir 18F (18F-AV-45) allows in vivo assessment of cerebral amyloid load and can be used in the evaluation of progression of Alzheimer's disease (AD) and other dementias associated with b-amyloid. However, co...

  • publication . Article . 2019
    Open Access
    Authors:
    Hao Hu; Ke-Liang Chen; Ya-Nan Ou; Xi-Peng Cao; Shi-Dong Chen; Mei Cui; Qiang Dong; Lan Tan; Jin-Tai Yu; null Alzheimer�s Disease Neuroimaging Initiative;
    Publisher: Impact Journals, LLC
    Project: CIHR , NIH | Alzheimers Disease Neuroi... (1U01AG024904-01)

    Previous studies demonstrated that plasma neurofilament light chain (NFL) played important predictive roles in disease progression and neurodegeneration in the preclinical phase of familial Alzheimer’s disease (AD). However, whether plasma NFL has the same predictive ro...

  • publication . Article . 2016
    Open Access English
    Authors:
    Matthews, Dawn C.; Lukic, Ana S.; Andrews, Randolph D.; Marendic, Boris; Brewer, James; Rissman, Robert A.; Mosconi, Lisa; Strother, Stephen C.; Wernick, Miles N.; Mobley, William C.; ...
    Publisher: Elsevier
    Project: NSF | SBIR Phase II: Early and ... (1256638), NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), CIHR

    AbstractIntroductionDown Syndrome (DS) adults experience accumulation of Alzheimer's disease (AD)–like amyloid plaques and tangles and a high incidence of dementia and could provide an enriched population to study AD-targeted treatments. However, to evaluate effects of ...

  • publication . Article . 2016
    Open Access English
    Authors:
    Bodily, Paul M.; Fujimoto, M. Stanley; Page, Justin T.; Clement, Mark J.; Ebbert, Mark T. W.; Ridge, Perry G.;
    Publisher: BioMed Central
    Project: CIHR , NIH | Alzheimers Disease Neuroi... (1U01AG024904-01)

    Background Genome-wide association studies (GWAS) have effectively identified genetic factors for many diseases. Many diseases, including Alzheimer’s disease (AD), have epistatic causes, requiring more sophisticated analyses to identify groups of variants which together...

  • publication . Article . 2019
    Open Access English
    Authors:
    Mei-Ling Tian; Xiao-Neng Ni; Jie-Qiong Li; Chen-Chen Tan; Xi-Peng Cao; Lan Tan; Lan Tan; for the Alzheimer’s Disease Neuroimaging Initiative;
    Publisher: Frontiers Media S.A.
    Project: NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), CIHR

    Background: rs9357347 located at the triggering receptor expressed on myeloid cells (TREM) gene cluster could increase TREM2 and TREM-like transcript 1 (TREML1) brain gene expression, which is considered to play a protective role against Alzheimer’s disease (AD). Object...

  • publication . Preprint . 2016
    Open Access English
    Authors:
    Hosseini-Asl, Ehsan; Gimel'farb, Georgy; El-Baz, Ayman;
    Project: CIHR , NIH | Alzheimers Disease Neuroi... (1U01AG024904-01)

    Early diagnosis, playing an important role in preventing progress and treating the Alzheimer's disease (AD), is based on classification of features extracted from brain images. The features have to accurately capture main AD-related variations of anatomical brain struct...

  • publication . Article . 2013
    Open Access English
    Authors:
    Cash, David M.; Ridgway, Gerard R.; Liang, Yuying; Ryan, Natalie S.; Kinnunen, Kirsi M.; Yeatman, Thomas; Malone, Ian B.; Benzinger, Tammie L.S.; Jack, Clifford R.; Thompson, Paul M.; ...
    Publisher: Lippincott Williams & Wilkins
    Project: NHMRC | Cognitive enhancement in ... (568807), NHMRC | Depressive and bipolar di... (1037196), NIH | TWO PRECLINICAL LATENT SC... (5R01AG034119-02), NIH | Memory Circuitry in MCI a... (2R01AG019771-06), NIH | HARDI Mapping of Disease ... (5R01EB008432-03), RCUK | Diffusion tensor imaging ... (G0900421), NIH | Administrative and Statis... (1P01NS059560-01A1), NIH | Algorithms to Map Disease... (5R21EB001561-03), NIH | Role of LRP &its ligand t... (5P50AG005681-19), NIH | BIO-INFORMATICS RESEARCH ... (1U24RR025736-01),...

    Objective: To assess regional patterns of gray and white matter atrophy in familial Alzheimer disease (FAD) mutation carriers. Methods: A total of 192 participants with volumetric T1-weighted MRI, genotyping, and clinical diagnosis were available from the Dominantly Inh...

  • publication . Article . 2015
    Open Access English
    Authors:
    Henley, David B; Dowsett, Sherie A; Chen, Yun-Fei; Liu-Seifert, Hong; Grill, Joshua D; Doody, Rachelle S; Aisen, Paul; Raman, Rema; Miller, David S; Hake, Ann M; ...
    Publisher: BioMed Central
    Project: NIH | VITAMIN E TRIAL IN PERSON... (5R01AG016381-07), NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), NIH | ALZHEIMERS DISEASE COOPER... (5U01AG010483-07), NIH | A Phase 2 Trial of AAV-NG... (1R01AG030048-01A1)

    © 2015 Henley et al.; licensee BioMed Central. Introduction: To facilitate enrollment and meet local registration requirements, sponsors have increasingly implemented multi-national Alzheimer's disease (AD) studies. Geographic regions vary on many dimensions that may af...

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