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1,017 research outcomes, page 1 of 102
  • publication . Article . 2017
    Open Access English
    Authors:
    Barbara S. Remus; Yehuda Goldgur; Stewart Shuman;
    Publisher: Oxford University Press
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NIH | NE-CAT Center for Advance... (4P41GM103403-14), NIH | Pixel Array Detector for ... (1S10RR029205-01), NIH | VACCINIA VIRUS MRNA TRANS... (2R01GM042498-10)

    Abstract Fungal tRNA ligase (Trl1) is an essential enzyme that repairs RNA breaks with 2′,3′-cyclic-PO4 and 5′-OH ends inflicted during tRNA splicing and non-canonical mRNA splicing in the fungal unfolded protein response. Trl1 is composed of C-terminal cyclic phosphodi...

  • publication . Article . 2014
    Open Access English
    Authors:
    He, Mu; Subramanian, Radhika; Bangs, Fiona; Omelchenko, Tatiana; Liem, Karel F.; Kapoor, Tarun M.; Anderson, Kathryn V.;
    Project: NIH | Genetic Analysis of Mouse... (5R01NS044385-14), NIH | MOUSE GENETICS (2P30CA008748-43)

    Mammalian Hedgehog (Hh) signal transduction requires the primary cilium, a microtubule-based organelle, and the Gli/Sufu complexes that mediate Hh signaling are enriched at cilia tips. KIF7, a kinesin-4 family protein, is a conserved regulator of the Hh signaling pathwa...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Demoin, Dustin Wayne; Wyatt, Linden C.; Edwards, Kimberly J.; Abdel-Atti, Dalya; Sarparanta, Mirkka; Pourat, Jacob; Longo, Valerie A.; Carlin, Sean D.; Engelman, Donald M.; Andreev, Oleg A.; ...
    Publisher: American Chemical Society
    Project: NIH | pHLIP-based agents for pr... (1F32CA186721-01A1), NIH | Shared Instrument: Focus ... (1S10RR020892-01), NIH | PET Imaging of Cancer wit... (5R01CA138468-04), NIH | The Ivis Spectrum CT for ... (1S10OD016207-01), NIH | MOUSE GENETICS (2P30CA008748-43), AKA | New radiolabeled molecula... (278056)

    pH (low) insertion peptides (pHLIP peptides) target acidic extracellular environments in vivo due to pH-dependent cellular membrane insertion. Two variants (Var3 and Var7) and wild-type (WT) pHLIP peptides have shown promise for in vivo imaging of breast cancer. Two pos...

  • publication . Article . 2016
    Open Access English
    Authors:
    Benjamin Lok;
    Publisher: Impact Journals LLC
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    // Jennifer Ma 1 , Jeremy Setton 1 , Luc Morris 2 , Pedro Blecua Carrillo Albornoz 1 , Christopher Barker 1 , Benjamin H. Lok 1 , Eric Sherman 3 , Nora Katabi 4 , Kathryn Beal 1 , Ian Ganly 2 , Simon N. Powell 1 , Nancy Lee 1 , Timothy A. Chan 1, 5 , Nadeem Riaz 1 1 Dep...

  • publication . Article . Other literature type . 2020
    Open Access English
    Authors:
    Qiongge Li; Gino Del Ferraro; Luca Pasquini; Kyung K. Peck; Hernán A. Makse; Andrei I. Holodny;
    Publisher: The MIT Press
    Project: NIH | MOUSE GENETICS (2P30CA008748-43), NSF | CRCNS: Targeted Stimulati... (1515022), NIH | Supplement: Network Metho... (3R01EB022720-03S1), NIH | Planning and Evaluation (5U54CA137788-03), NIH | Developmental Core (5U54CA132378-03)

    Functional magnetic resonance imaging (fMRI) is widely used in clinical applications to highlight brain areas involved in specific cognitive processes. Brain impairments, such as tumors, suppress the fMRI activation of the anatomical areas they invade and, thus, brain-d...

  • publication . Article . 2017
    Open Access
    Authors:
    Kavaler, Joshua; Duan, Hong; Aradhya, Rajaguru; de Navas, Luis F.; Joseph, Brian; Shklyar, Boris; Lai, Eric C.;
    Publisher: Rockefeller University Press
    Project: NIH | BEN factors are conserved... (5R01NS074037-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Mechanism and regulation ... (2R01NS083833-06), NIH | Non-canonical miRNA bioge... (2R01GM083300-06)

    Large-scale knockout studies suggest that most miRNAs are phenotypically dispensable. However, Kavaler et al. show here that developmental specification toward a non-neuronal fate in the Drosophila melanogaster peripheral sensory organ lineage depends critically on mir-...

  • publication . Article . 2017
    Open Access English
    Authors:
    Priya Nori; Theresa Madaline; Iona Munjal; Shubha Bhar; Yi Guo; Susan K. Seo; Andrea Porrovecchio; Elizabeth Gancher; Joshua Nosanchuk; Liise-anne Pirofski; ...
    Publisher: Oxford University Press
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    Abstract Background. To impart principles of antimicrobial stewardship (AS) and infection prevention and control (IPC), we developed a curriculum tailored to the diverse aptitudes of learners at our medical center. Methods. We integrated case-based modules, group learni...

  • publication . Article . 2015
    Open Access English
    Authors:
    Stefan Harmsen; Matthew A. Bedics; Matthew A. Wall; Ruimin Huang; Michael R. Detty; Moritz F. Kircher;
    Project: NSF | Collaborative Research: T... (1151379), NIH | MOUSE GENETICS (2P30CA008748-43), NSF | IGERT: Returning the Radi... (0965983), NIH | Combined Pre & Intraopera... (4K08CA163961-05), NIH | MRI-Photoacoustic-Raman N... (1R01EB017748-01A1)

    High sensitivity and specificity are two desirable features in biomedical imaging. Raman imaging has surfaced as a promising optical modality that offers both. Here, we report the design and synthesis of a group of near infrared absorbing 2-thienyl-substituted chalcogen...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Guercio, Brendan J.; Zhang, Sui; Niedzwiecki, Donna; Li, Yanping; Babic, Ana; Morales-Oyarvide, Vicente; Saltz, Leonard B.; Mayer, Robert J.; Mowat, Rex B.; Whittom, Renaud; ...
    Publisher: Public Library of Science
    Project: NIH | Network Lead Academic Par... (3U10CA180791-04S1), NIH | NCI National Clinical Tri... (5U10CA180836-02), NIH | ECOG-ACRIN Operations Cen... (3U10CA180820-02S3), NIH | NCTN Lead Academic Partic... (5U10CA180867-04), NIH | The Influence of Diet and... (5R01CA149222-05), NIH | Role of Vitamin D, Inflam... (5K07CA148894-02), NIH | MOUSE GENETICS (2P30CA008748-43), NIH | Accelerating Transdiscipl... (5R35CA197735-04), NIH | Alliance for Clinical Tri... (3U10CA180821-02S2), NIH | Multidisciplinary Trainin... (5T32HL125232-02),...

    Purpose Observational studies have demonstrated increased colon cancer recurrence and mortality in states of excess energy balance, as denoted by factors including sedentary lifestyle, diabetes, increased dietary glycemic load, and increased intake of sugar-sweetened be...

  • publication . Article . 2018
    Open Access
    Authors:
    Tollinche, Luis; Jackson, Jacob; La, Melvin; Desiderio, Dawn; Yeoh, Cindy;
    Publisher: Scitechnol Biosoft Pvt. Ltd.
    Project: NIH | MOUSE GENETICS (2P30CA008748-43)

    We report a case in which a radial arterial line was placed prior to induction of general anaesthesia in a 76 year old male with prostate cancer and multiple co-morbidities who presented for thoracoscopic resection of a right lower lobe carcinoid lung tumor. The patient...

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