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110 research outcomes, page 1 of 11
  • publication . Article . 2011
    Open Access
    Authors:
    Zhernakova, Alexandra; Stahl, Eli A.; Trynka, Gosia; Raychaudhuri, Soumya; Festen, Eleanora A.; Franke, Lude; Westra, Harm-Jan; Fehrmann, Rudolf S. N.; Kurreeman, Fina A. S.; Thomson, Brian; ...
    Publisher: Public Library of Science (PLoS)
    Project: NIH | Genetic predictors of res... (1U01GM092691-01), NWO | Identifying causative cop... (2300159001), SFI | Post-genomic investigatio... (09/IN.1/B2640), NIH | Dissection of two rheumat... (1R01AR056768-01), NIH | Bioinformatics and Popula... (1K08AR055688-01A1), CIHR , NIH | AN NCRR CENTER FOR HIGH T... (5U54RR020278-04), EC | MASTERSWITCH (223404), EC | CD40RA (237280), NWO | Characterization of share... (2300160780),...

    Epidemiology and candidate gene studies indicate a shared genetic basis for celiac disease (CD) and rheumatoid arthritis (RA), but the extent of this sharing has not been systematically explored. Previous studies demonstrate that 6 of the established non-HLA CD and RA r...

  • publication . Article . 2014
    Open Access English
    Authors:
    Gisela Ruiz-Heiland; Yi Zhao; Anja Derer; Tobias Braun; Klaus Engelke; Elena Neumann; Ulf Mueller-Ladner; Yi Liu; Jochen Zwerina; Georg Schett;
    Project: EC | MASTERSWITCH (223404)

    Objective To test whether the tyrosine kinase Tyro3 affects arthritis. Tyro3, the ligand of growth arrest–specific protein 6 (GAS6) is a receptor tyrosine kinase involved in cell survival. Tyro3 and GAS6 are expressed in the arthritic synovium, and in vitro studies have...

  • publication . Article . Other literature type . 2011
    Open Access English
    Authors:
    Uderhardt S; Herrmann M; Olga Oskolkova; Voll R; Nimmerjahn F; Bochkov V; Schett G; Kroenke G;
    Publisher: Springer Nature
    Project: EC | MASTERSWITCH (223404)

    The coordinated and non-inflammatory phagocytosis of apoptotic cells is crucial to maintain immunological tolerance. During inflammation, however, ingestion of apoptotic material by inflammatory phagocytes can provoke a break in self-tolerance. Hence, and though poorly ...

  • publication . Article . 2011
    Open Access English
    Authors:
    Janko, Christina; Franz, Sandra; Luis Munoz; Siebig, Stefan; Winkler, Silke; Schett, Georg; Lauber, Kirsten; Sheriff, Ahmed; Vlag, Johan; Herrmann, Martin;
    Publisher: Frontiers Media S.A.
    Project: EC | MASTERSWITCH (223404)

    Systemic Lupus Erythematosus (SLE) is a chronic inflammatory disease characteris¬ed by the production of autoantibodies, formation of immune complexes (IC), and activation of complement that ultimately fuel acute and/or chronic inflammation. Accumulation in blood a...

  • publication . Article . 2013
    Open Access
    Authors:
    Spee, C. v.; Wassermann, N.; Humrich, J.; Riemekasten, G.;
    Publisher: BMJ
    Project: EC | MASTERSWITCH (223404)

    Background Phenotypic and quantitative abnormalities of regulatory T cells have been described in association with systemic lupus erythematosus (SLE). Further, an impaired production of IL-2, the essential cytokine for Treg homeostasis, has been described for T cells fr...

  • publication . Article . Other literature type . 2011
    Open Access English
    Authors:
    Clara Dees; Alfiya Akhmetshina; Pawel Zerr; Nicole Reich; Katrin Palumbo; Angelika Horn; Astrid Jüngel; Christian Beyer; Gerhard Krönke; Jochen Zwerina; ...
    Publisher: HAL CCSD
    Project: EC | MASTERSWITCH (223404)

    Vascular damage and platelet activation are associated with tissue remodeling in diseases such as systemic sclerosis, but the molecular mechanisms underlying this association have not been identified. In this study, we show that serotonin (5-hydroxytryptamine [5-HT]) st...

  • publication . Other literature type . Article . 2013
    Open Access English
    Authors:
    Marilena Colaianna; Stefania Schiavone; Margherita Zotti; Paolo Tucci; Maria Grazia Morgese; Liselotte Bäckdahl; Rikard Holmdahl; Karl-Heinz Krause; Vincenzo Cuomo; Luigia Trabace;
    Publisher: Mary Ann Liebert, Inc.
    Project: EC | MASTERSWITCH (223404), SNSF | NOX enzymes: focus on the... (310030B_141182)

    Aims: Psychosocial stress alters the hypothalamic-pituitary-adrenal axis (HPA-axis). Increasing evidence shows a link between these alterations and oxidant elevation. Oxidative stress is implicated in the stress response and in the pathogenesis of neurologic and psychia...

  • publication . Article . Other literature type . 2011
    Open Access
    Authors:
    Neal L Millar;
    Publisher: The American Association of Immunologists
    Project: EC | MASTERSWITCH (223404)

    IL-33 is a new member of the IL-1 family, which plays a crucial role in inflammatory response, enhancing the differentiation of dendritic cells and alternatively activated macrophages (AAM). Based on the evidence of IL-33 expression in bone, we hypothesized that IL-33 m...

  • publication . Article . 2013
    Open Access English
    Authors:
    Miller, Ashley M.; Gilchrist, Derek S.; Nijjar, Jagtar; Araldi, Elisa; Ramirez, Cristina M.; Lavery, Christopher A.; Fernández-Hernando, Carlos; McInnes, Iain B.; Kurowska-Stolarska, Mariola;
    Publisher: Public Library of Science
    Project: EC | MASTERSWITCH (223404)

    Hepatic steatosis is a global epidemic that is thought to contribute to the pathogenesis of type 2 diabetes. MicroRNAs (miRs) are regulators that can functionally integrate a range of metabolic and inflammatory pathways in liver. We aimed to investigate the functional r...

  • publication . Article . 2013
    Open Access
    Authors:
    Aradi, B.; Filkova, M.; Kasper, S.; Klein, K.; Scharl, M.; Michel, B. A.; Gay, R. E.; Buzas, E. I.; Gay, S.; Jungel, A.;
    Publisher: BMJ
    Project: EC | MASTERSWITCH (223404)

    Background and Objectives Protein Tyrosine Phosphatase Nonreceptor Type 2 (PTPN2) is a protein tyrosine phosphatase that plays a role in the development of autoimmune diseases. PTPN2 function has not been studied in rheumatoid arthritis (RA), although single nucleotide ...

110 research outcomes, page 1 of 11
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