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104 research outcomes, page 1 of 11
  • publication . Article . Other literature type . 2012
    Open Access English
    Authors:
    Denis Shields;
    Publisher: Elsevier
    Project: EC | ATHEROREMO (201668)

    Genome-wide association studies (GWASs) have identified many SNPs underlying variations in plasma-lipid levels. We explore whether additional loci associated with plasma-lipid phenotypes, such as high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein chol...

  • publication . Article . Review . Other literature type . 2010
    Open Access
    Authors:
    Diego Diez; Am, Wheelock; Goto S; Jz, Haeggström; Paulsson-Berne G; Gk, Hansson; Hedin U; Gabrielsen A; Ce, Wheelock;
    Publisher: Royal Society of Chemistry (RSC)
    Project: EC | ATHEROREMO (201668)

    Systems biology offers the potential to provide new insights into our understanding of the pathogenesis of complex diseases such as atherosclerosis. It seeks to comprehend the system properties of the non-linear interactions of the multiple biomolecular components that ...

  • publication . Article . Other literature type . 2014
    Open Access
    Authors:
    Tuomisto, Sari; Pessi, Tanja; Collin, Pekka; Vuento, Risto; Aittoniemi, Janne; Karhunen, Pekka J;
    Publisher: Springer Science and Business Media LLC
    Project: EC | ATHEROREMO (201668)

    Background The liver is the first line of defence against continuously occurring influx of microbial-derived products and bacteria from the gut. Intestinal bacteria have been implicated in the pathogenesis of alcoholic liver cirrhosis. Escape of intestinal bacteria into...

  • publication . Article . 2017
    Open Access English
    Authors:
    de Vries, Paul S.; Sabater-Lleal, Maria; Chasman, Daniel I.; Trompet, Stella; Ahluwalia, Tarunveer S.; Teumer, Alexander; Kleber, Marcus E.; Chen, Ming-Huei; Wang, Jie Jin; Attia, John R.; ...
    Project: NIH | TRIAL OF ASPIRIN AND VITA... (5R01CA047988-10), NIH | THE FRAMINGHAM HEART STUD... (N01HC025195-005), WT | The genetics of weight, B... (076113), NIH | CORONARY HEART DISEASE AN... (N01HC085079-023), NIH | CENTRAL BLOOD ANALYSIS LA... (N01HC085086-019), NIH | Integration of Genomics &... (5RC2MH089951-02), NIH | CHS Events Follow-up Stud... (1U01HL080295-01), NHMRC | Blue Mountains Cohort Stu... (211069), NIH | Collaborative GWAS of Dem... (1R01AG033193-01), NIH | HISPANIC SECONDARY STROKE... (1R01MD009164-01),...

    <p>An increasing number of genome-wide association (GWA) studies are now using the higher resolution 1000 Genomes Project reference panel (1000G) for imputation, with the expectation that 1000G imputation will lead to the discovery of additional associated loci when com...

  • publication . Article . Review . 2012
    Open Access English
    Authors:
    Fabrizio Montecucco; Braunersreuther, Vincent; Viviani, Giorgio Luciano; Lenglet, Sebastien; Mach, Francois;
    Publisher: BENTHAM SCIENCE PUBL LTD
    Project: SNSF | Selective anti-inflammato... (310030B_133127), EC | ATHEROREMO (201668), SNSF | Role of visfatin on infla... (32003B_134963), SNSF | Management-Ethik (9010-032002)

    Acute atherosclerotic complications, such as myocardial infarction, are often provoked by the rupture of an atherosclerotic plaque and the subsequent thrombotic occlusion of the arterial lumen, which interrupts the blood flow and renders ischemic the downstream peripher...

  • publication . Article . Other literature type . 2013
    Open Access
    Authors:
    Seneviratne, A.; Hulsmans, M.; Holvoet, P.; Monaco, C.;
    Publisher: Oxford University Press (OUP)
    Project: EC | ATHEROREMO (201668)

    Thin-cap fibroatheromas (TCFAs) or vulnerable atherosclerotic plaques are considered a high-risk phenotype for acute cardiovascular events. TCFAs are identified by a thin rupture-prone fibrous cap, a large necrotic core, and a high content of leucocytes. Atherogenesis i...

  • publication . Article . Other literature type . 2013
    Open Access
    Authors:
    O'Seaghdha, Conall M.; Wu, Hongsheng; Yang, Qiong; Kapur, Karen; Guessous, Idris; Zuber, Annie Mercier; Köttgen, Anna; Stoudmann, Candice; Teumer, Alexander; Kutalik, Zoltán; ...
    Project: NIH | HEALTH ABC--COORDINATING ... (N01AG062106-019), NIH | CTSA INFRASTRUCTURE FOR A... (1UL1RR033176-01), NIH | UCLA Clinical and Transla... (5UL1TR000124-04), NIH | THE FRAMINGHAM HEART STUD... (N01HC025195-005), NIH | CORONARY HEART DISEASE AN... (N01HC085079-023), NIH | CENTRAL BLOOD ANALYSIS LA... (N01HC085086-019), WT | Genomics of quantitative ... (091746), SNSF | Renal calcium and uric ac... (PP00P3_133648), SNSF | Maintaining homeostasis o... (31003A_149440), EC | GEFOS (201865),...

    Calcium is vital to the normal functioning of multiple organ systems and its serum concentration is tightly regulated. Apart from CASR, the genes associated with serum calcium are largely unknown. We conducted a genome-wide association meta-analysis of 39,400 individual...

  • publication . Article . 2012
    Open Access English
    Authors:
    Monaco, Claudia;
    Publisher: Bentham Science Publishers B.V.
    Project: EC | ATHEROREMO (201668)

    Inflammation drives atherosclerosis. Toll-like receptor-2 and -4 are so far the strongest candidates for initiating innate immune signalling in atherosclerosis. Their signalling has implications for lesion development, foam cell formation, inflammation, matrix degradati...

  • publication . Article . Other literature type . 2013
    Open Access
    Authors:
    Markus, H. S.; Makela, K.-M.; Bevan, S.; Raitoharju, E.; Oksala, N.; Bis, J. C.; O'Donnell, C.; Hainsworth, A.; Lehtimaki, T.;
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Project: EC | ATHEROREMO (201668)

    Background and Purpose—A novel association between a single nucleotide polymorphism on chromosome 7p21.1 and large-vessel ischemic stroke was recently identified. The most likely underlying gene is histone deacetylase 9 (HDAC9). The mechanism by which HDAC9 increases st...

  • publication . Article . 2017
    Open Access English
    Authors:
    Marco Busnelli; Stefano Manzini; Mika Hilvo; Cinzia Parolini; Giulia S. Ganzetti; Federica Dellera; Kim Ekroos; Minna Jänis; Diana Escalante-Alcalde; Cesare R. Sirtori; ...
    Project: EC | RISKYCAD (305739), EC | ATHEROREMO (201668)

    The PLPP3 gene encodes for a ubiquitous enzyme that dephosphorylates several lipid substrates. Genome-wide association studies identified PLPP3 as a gene that plays a role in coronary artery disease susceptibility. The aim of the study was to investigate the effect of P...

104 research outcomes, page 1 of 11
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