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100 research outcomes, page 1 of 10
  • publication . Article . Other literature type . 2009
    Open Access English
    Authors:
    Christoph Ruckenstuhl; Sabrina Büttner; Didac Carmona-Gutierrez; Tobias Eisenberg; Guido Kroemer; Stephan J Sigrist; Kai-Uwe Fröhlich; Frank Madeo;
    Publisher: Public Library of Science
    Project: EC | APO-SYS (200767)

    BACKGROUND: Otto Warburg observed that cancer cells are often characterized by intense glycolysis in the presence of oxygen and a concomitant decrease in mitochondrial respiration. Research has mainly focused on a possible connection between increased glycolysis and tum...

  • publication . Article . 2010
    Open Access English
    Authors:
    Aho, Tommi; Almusa, Henrikki; Matilainen, Jukka; Larjo, Antti; Ruusuvuori, Pekka; Aho, Kaisa-Leena; Wilhelm, Thomas; Lähdesmäki, Harri; Beyer, Andreas; Harju, Manu; ...
    Publisher: PUBLIC LIBRARY SCIENCE
    Project: EC | APO-SYS (200767)

    Molecular interaction networks establish all cell biological processes. The networks are under intensive research that is facilitated by new high-throughput measurement techniques for the detection, quantification, and characterization of molecules and their physical in...

  • publication . Article . 2009
    Open Access
    Authors:
    Prehn, Jochen H. M.; Huber, Heinrich J.; Wellstead, Peter E.; Rehm, Markus; Kalamatianos, Dimitrios; Dü ssmann, Heiko; Wenus, Jakub; Paul, Perrine;
    Publisher: Future Science Ltd
    Project: EC | APO-SYS (200767)

    Probe photobleaching and a specimen’s sensitivity to phototoxicity severely limit the number of possible excitation cycles in time-lapse fluorescent microscopy experiments. Consequently, when a study of cellular processes requires measurements over hours or days, tempor...

  • publication . Article . 2011
    Open Access
    Authors:
    Lascorz, Jesus; Chen, Bowang; Hemminki, Kari; Forsti, Asta;
    Publisher: Public Library of Science (PLoS)
    Project: EC | APO-SYS (200767)

    Background: A large number of gene expression profiling (GEP) studies on prognosis of colorectal cancer (CRC) has been performed, but no reliable gene signature for prediction of CRC prognosis has been found. Bioinformatic enrichment tools are a powerful approach to ide...

  • publication . Other literature type . Article . 2009
    Open Access English
    Authors:
    Mille, Frédéric; Thibert, Chantal; Fombonne, Joanna; Rama, Nicolas; Guix, Catherine; Hayashi, Hideki; Corset, Véronique; Reed, John C.; Mehlen, Patrick;
    Publisher: Macmillan Magazines Ltd.
    Project: EC | APO-SYS (200767)

    International audience; Sonic hedgehog (Shh) and its main receptor, Patched (Ptc), are implicated in both neural development and tumorigenesis. Besides its classic morphogenic activity, Shh is also a survival factor. Along this line, Ptc has been shown to function as a ...

  • publication . Article . 2011
    Open Access English
    Authors:
    Shoval Yishay; Berissi Hanna; Kimchi Adi; Pietrokovski Shmuel;
    Publisher: Public Library of Science
    Project: EC | APO-SYS (200767)

    DRP-1 and ZIPk are two members of the Death Associated Protein Ser/Thr Kinase (DAP-kinase) family, which function in different settings of cell death including autophagy. DAP kinases are very similar in their catalytic domains but differ substantially in their extra-cat...

  • publication . Article . Other literature type . 2008
    Open Access
    Authors:
    Tasdemir, Ezgi; Maiuri, M. Chiara; Galluzzi, Lorenzo; Vitale, Ilio; Djavaheri-Mergny, Mojgan; D'Amelio, Marcello; Criollo, Alfredo; Morselli, Eugenia; Zhu, Changlian; Harper, Francis; ...
    Publisher: Springer Science and Business Media LLC
    Project: EC | APO-SYS (200767)

    Multiple cellular stressors, including activation of the tumour suppressor p53, can stimulate autophagy. Here we show that knockout, knockdown or pharmacological inhibition of p53 can induce autophagy in human, mouse and nematode cells. Enhanced autophagy improved the s...

  • publication . Article . Other literature type . 2010
    Open Access English
    Authors:
    Guenebeaud, Céline; Goldschneider, David; Castets, Marie; Guix, Catherine; Chazot, Guillaume; Delloye-Bourgeois, Céline; Eisenberg-Lerner, Avital; Shohat, Galit; Zhang, Mingjie; Laudet, Vincent; ...
    Publisher: HAL CCSD
    Project: EC | APO-SYS (200767)

    The UNC5H dependence receptors promote apoptosis in the absence of their ligand, netrin-1, and this is important for neuronal and vascular development and for limitation of cancer progression. UNC5H2 (also called UNC5B) triggers cell death through the activation of the ...

  • publication . Article . Review . 2012
    Open Access English
    Authors:
    Fulda, Simone;
    Publisher: Hindawi Publishing Corporation
    Project: EC | APO-SYS (200767)

    <jats:p>Resistance of rhabdomyosarcoma to current therapies remains one of the key issues in pediatric oncology. Since the success of most cytotoxic therapies in the treatment of cancer, for example, chemotherapy, depends on intact signaling pathways that mediate progra...

  • publication . Other literature type . Article . 2010
    Open Access English
    Authors:
    J. Yuan; G. Kroemer;
    Publisher: Cold Spring Harbor Laboratory Press
    Project: EC | APO-SYS (200767)

    A canonical regulatory pathway involving the members of the Bcl-2 and caspase families has been established to regulate developmental apoptosis in nematodes and flies. However, mutant mice that have major deficiencies in this apoptosis pathway show only relatively minor...

100 research outcomes, page 1 of 10
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