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112 research outcomes, page 1 of 12
  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Alpízar, Adán; Marino, Fabio; Ramos-Fernández, Antonio; Lombardía, Manuel; Jeko, Anita; Pazos, Florencio; Paradela, Alberto; Santiago, César; Heck, Albert J. R.; Marcilla, Miguel;
    Publisher: American Society for Biochemistry & Molecular Biology (ASBMB)
    Project: EC | PRIME-XS (262067), EC | MSmed (686547), NWO | Proteins@Work; A large-sc... (2300171290)

    As aberrant protein phosphorylation is a hallmark of tumor cells, the display of tumor-specific phosphopeptides by Human Leukocyte Antigen (HLA) class I molecules can be exploited in the treatment of cancer by T-cell-based immunotherapy. Yet, the characterization and pr...

  • publication . Article . 2013
    Open Access English
    Authors:
    Hulstaert, Niels; Reisinger, Florian; Rameseder, Jonathan; Barsnes, Harald; Vizcaíno, Juan Antonio; Martens, Lennart;
    Publisher: Elsevier
    Project: EC | PRIME-XS (262067), WT | The Proteomics Identifica... (085949), EC | PROTEOMEXCHANGE (260558), EC | LIPIDOMICNET (202272)

    Graphical abstract

  • publication . Article . Other literature type . 2018
    Open Access
    Authors:
    Aiche Stephan; Sachsenberg Timo; Kenar Erhan; Walzer Mathias; Wiswedel Bernd; Kristl Theresa; Boyles Matthew; Duschl Albert; Huber Christian G.; Berthold Michael R.; ...
    Publisher: Wiley
    Project: EC | MARINA (263215), EC | NANOVALID (263147), EC | PRIME-XS (262067)

    MS-based proteomics and metabolomics are rapidly evolving research fields driven by the development of novel instruments, experimental approaches, and analysis methods. Monolithic analysis tools perform well on single tasks but lack the flexibility to cope with the cons...

  • publication . Article . Other literature type . 2012
    Open Access English
    Authors:
    Ja, Vizcaíno; Rg, Côté; Csordas A; Ja, Dianes; Fabregat A; Jm, Foster; Griss J; Alpi E; Birim M; Contell J; ...
    Publisher: Oxford University Press
    Project: WT | The Proteomics Identifica... (085949), EC | PRIME-XS (262067), EC | SLING (226073), EC | LIPIDOMICNET (202272), EC | PROTEOMEXCHANGE (260558), RCUK | PRIDE Converter - Efficie... (BB/I024204/1)

    The PRoteomics IDEntifications (PRIDE, http://www.ebi.ac.uk/pride) database at the European Bioinformatics Institute is one of the most prominent data repositories of mass spectrometry (MS)-based proteomics data. Here, we summarize recent developments in the PRIDE datab...

  • publication . Article . 2012
    Open Access English
    Authors:
    Nahnsen Sven; Kohlbacher Oliver;
    Publisher: BioMed Central
    Project: EC | PRIME-XS (262067)

    <p>Abstract</p> <p>Selected reaction monitoring (SRM)-based proteomics approaches enable highly sensitive and reproducible assays for profiling of thousands of peptides in one experiment. The development of such assays involves the determination of retention time, detec...

  • publication . Doctoral thesis . 2015
    Open Access English
    Authors:
    Corradini, E.;
    Publisher: Utrecht University
    Project: NWO | Proteins@Work; A large-sc... (2300171290), EC | PRIME-XS (262067)

    Understanding the molecular mechanisms which regulate signal transduction is fundamental to the development of therapeutic molecules for the treatment of several diseases. In particular, signaling proteins, such as cyclic nucleotide dependent enzymes are the orchestrato...

  • publication . Article . 2013
    Open Access English
    Authors:
    Fannes, Thomas; Vandermarliere, Elien; Schietgat, Leander; Degroeve, Sven; Martens, Lennart; Ramon, Jan;
    Project: EC | PROTEOMEXCHANGE (260558), EC | PRIME-XS (262067), EC | MIGRANT (240186)

    Trypsin is the workhorse protease in mass spectrometry-based proteomics experiments and is used to digest proteins into more readily analyzable peptides. To identify these peptides after mass spectrometric analysis, the actual digestion has to be mimicked as faithfully ...

  • publication . Article . Other literature type . 2012
    Open Access
    Authors:
    Franz-Wachtel Mirita; Eisler Stephan A.; Krug Karsten; Wahl Silke; Carpy Alejandro; Nordheim Alfred; Pfizenmaier Klaus; Hausser Angelika; Macek Boris;
    Publisher: American Society for Biochemistry & Molecular Biology (ASBMB)
    Project: EC | PRIME-XS (262067)

    Protein kinase D (PKD) is a cytosolic serine/threonine kinase implicated in regulation of several cellular processes such as response to oxidative stress, directed cell migration, invasion, differentiation, and fission of the vesicles at the trans-Golgi network. Its var...

  • publication . Review . Article . 2015
    Open Access English
    Authors:
    Eric Deutsch;
    Project: EC | AFFINOMICS (241481), NIH | Complete Human Peptide- a... (1RC2HG005805-01), WT | PRIDE Atlas. (101477), RCUK | PROCESS - Proteomics data... (BB/K01997X/1), EC | PRIME-XS (262067), EC | PROTEOMEXCHANGE (260558), NIH | Development of Trans Prot... (5R01GM087221-07)

    OBJECTIVE: To describe the goals of the Proteomics Standards Initiative (PSI) of the Human Proteome Organization, the methods that the PSI has employed to create data standards, the resulting output of the PSI, lessons learned from the PSI's evolution, and future direct...

  • publication . Article . Other literature type . 2015
    Open Access English
    Authors:
    Giansanti, Piero; Aye, Thin Thin; van den Toorn, Henk; Peng, Mao; van Breukelen, Bas; Heck, Albert J.R.;
    Project: NWO | Proteins@Work; A large-sc... (2300171290), EC | PRIME-XS (262067)

    Summary Although mass-spectrometry-based screens enable thousands of protein phosphorylation sites to be monitored simultaneously, they often do not cover important regulatory sites. Here, we hypothesized that this is due to the fact that nearly all large-scale phosphop...

112 research outcomes, page 1 of 12
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