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ENGAGE(603)NCHA Subsidiebesluit 2008-2012(154)Genetics of cardiovascular risk factors in large founder population birth control(125)THE FRAMINGHAM HEART STUDY-268025195(112)Whole Genome Assoc. Analysis Strategies for Multi. Phenotypes(109)GMI(99)Institute for Clinical and Translational Research (UL1)(98)CORONARY HEART DISEASE AND STROKE(96)Genetic Influences on ADHD in a Finnish Birth Cohort(94)GWA for Gene-Environment Interaction Effects Influencing CHD(92)CENTRAL BLOOD ANALYSIS LABORATORY FOR CHS(88)GEFOS(84)The genetics of weight, BMI, adiposity and obesity(84)Genome-Wide Association for Loci Influencing CHD and Other Heart, Lung and Blood(81)tweeling onderzoek, met een focus op gedrag en depressie(80)CHS-Transition Phase -268055222(78)Genome-wide combined linkage-association scan of multiply phenotyped twin sibships(77)Centre for molecular-based causal analyses in health and disease(77)CHARGE consortium: gene discovery for CVD and aging phenotypes(76)A Genome-Wide Association Study in Essential Hypertension (FEHGAS2)(76)Validation and Replication of Genes Associated with Common Human Disease Using Australian Twin Families(74)NIMH Center for Collaborative Genetic Studies(73)A national DNA control series for genetic case-control studies based on the British 1958 birth cohort(73)Mapping Genes for typical migraine using twin families.(72)Cluster computing in genetic linkage studies on human complex traits(72)Epidemiology of Venous Thrombosis &Pulmonary Embolism(69)Dissecting genetic complexity of Alzheimer's disease and cognitive function(69)Genetics of melanoma risk factors(68)Genetics of melanoma risk factors(67)Twin-family database for behavior genetics and genomics studies(67)Cardiovascular diseases and psychiatric disorders in the general population: a prospective follow-up study(66)Association Screen of High Priority Positional Candidate Genes for Migraine(65)Assessment of biomedical risk factors and disease outcomes in the British 1958 cohort(65)Investigating the role of pigmentation pathway genes in moliness and melanoma risk(64)CHS Events Follow-up Study(61)CORONARY HEART DISEASE &STROKE IN THE ELDERLY(60)WGA Study to Identify Genetic Variants Associated with CV Events in CHS(60)AGES STUDY-THE REYKJAVIK STUDY OF HEALTHY AGING FOR THE NEW MILLENNIUM-260012100(59)Type 1 Diabetes Genetics Consortium(59)CORONARY HEART DISEASE AND STROKE(58)CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84(58)Statistical Methods and Algorithms for Analysis of High-throughput Genetics and Genomics Platforms(57)CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84(57)Research Fellowship - Grant ID:442915(55)UCLA Clinical and Translational Science Institute(55)CCSP - FIELD CENTER AND ULTRASOUND READING CENTER(55)CCSP-FIELD CENTER(53)BIOSHARE-EU(50)Develop & improve methodology in gene mapping, targetting localisation of genes underlying migraine & other disorders(50)COMMUNITY AND COHORT SURVEILLANCE PROGRAM(49)CCSP - FIELD CENTER(49)FIELD CENTER FOR CCSP(48)CANDIDATE GENE STUDIES OF OBESITY GUIDED BY WHOLE GENOME ASSOCIATION DATA(48)Integration of Genomics &Transcriptomics in Normal Twins &Major Depression(46)Candidate gene variation and the association between early growth and adult disease: studies in the 1966 Northern Finland Birth Cohort(46)CARDIOVASCULAR HEALTH STUDY--ECHOCARDIOGRAPHY(45)COMMUNITY AND COHORT SURVEILLANCE PROGRAMS(45)BBMRI-NL(45)PHASE(44)CENTRAL HEMOSTATIS LABORATORY FOR CCSP(44)MRI READING CENTER FOR THE CARDIOVASCULAR HEALTH STUDY(44)Understanding the genetic basis of common human diseases: core funding for the Wellcome Trust Centre for Human Genetics.(44)Maximising knowledge from dense SNP (single nucleotide polymorphisms) data using multi-locus analysis(43)Genetic analysis of type II diabetes in Finnish populati(43)Genome Wide Association Coordinating Center(43)Major Depression: Stage 1 Genomewide Association in Population-Based Samples(43)Wellcome Trust Sanger Institute - generic account for deposition of all core- funded research papers(43)Prospective meta-analyses of drug-gene interactions: CHARGE GWAS consortium(42)OPENGENE(41)ATHEROREMO(41)Identifying Genes for Type 2 Diabetes: FUSION(41)Exceptional aging: 12 year trajectories to function(41)Genome-wide association studies of biomedical traits and endophenotypes for complex disease(40)EURHEALTHAGEING(39)SUBCLINICAL CARDIOVASCULAR DISEASE COORDINATING CENTER-268995159(39)CORE--ADIPOSE TISSUE BIOLOGY AND BASIC MECHANISMS(39)CHS-ULTRASOUND READING(39)SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--EBCT READING(38)Identification of genetic risk factors for asthma: genome-wide association and the role of epigenetics(37)CHS RETINAL READING CENTER(37)TRIAL OF ASPIRIN AND VITAMIN E IN WOMEN(37)Cambridge Institute for Medical Research (CIMR).(37)VARIATION IN THE EFFECTS OF ALCOHOL ON LIVER FUNCTION(35)Locating genes for elementary and complex cognitive abilities using genetic linkage and association analysis(34)HYPERGENES(34)Genetics of common neurological diseases.(33)Genome-wide Association in Families: Data Integrity, Design and Methods Issue(32)Identification of genetic variants underlying coronary artery disease and associated phenotypes in Indian Asians.(32)Quantitative and Molecular Genetic Analysis of Cognition(31)AN NCRR CENTER FOR HIGH THROUGHPUT SNP GENOTYPING AND ANALYSIS: GAIN NETWORK(31)Genome-wide Search for CVD Gene-Environment Interactions(31)Cardiovascular diseases and psychiatric disorders in the general population: a prospective follow-up study(31)JH/CIDR Genotyping for Genome-Wide Association Studies(30)Molecular Epidemiology of Alcoholism 3 - EDAC Families(30)Genetic Architecture of Adiposity in Multiple Large Cohorts(30)DYNAMICS OF HEALTH .AGING . AND BODY COMPOSITION /Pittsburgh/-260962101(30)HEALTH ABC--COORDINATING UNIT-260962106(30)SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTER(30)WTCCC2 core activities.(30)
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European Commission(603)Wellcome Trust(387)National Institutes of Health(365)Netherlands Organisation for Scientific Research (NWO)(230)View moreResearch Council UK(170)Funder
European Commission(603)Wellcome Trust(387)National Institutes of Health(365)Netherlands Organisation for Scientific Research (NWO)(230)Research Council UK(170)National Health and Medical Research Council (NHMRC)(153)Swiss National Science Foundation(91)Australian Research Council (ARC)(73)Croatian Science Foundation (CSF)(23)Austrian Science Fund (FWF)(21)Ministry of Science, Education and Sports of the Republic of Croatia (MSES)(19)National Science Foundation(13)Fundação para a Ciência e a Tecnologia, I.P.(5)Science Foundation Ireland(3)
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ENGAGE(603)NCHA Subsidiebesluit 2008-2012(154)Genetics of cardiovascular risk factors in large founder population birth control(125)THE FRAMINGHAM HEART STUDY-268025195(112)View moreWhole Genome Assoc. Analysis Strategies for Multi. Phenotypes(109)Project
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Phenotypes(109)GMI(99)Institute for Clinical and Translational Research (UL1)(98)CORONARY HEART DISEASE AND STROKE(96)Genetic Influences on ADHD in a Finnish Birth Cohort(94)GWA for Gene-Environment Interaction Effects Influencing CHD(92)CENTRAL BLOOD ANALYSIS LABORATORY FOR CHS(88)GEFOS(84)The genetics of weight, BMI, adiposity and obesity(84)Genome-Wide Association for Loci Influencing CHD and Other Heart, Lung and Blood(81)tweeling onderzoek, met een focus op gedrag en depressie(80)CHS-Transition Phase -268055222(78)Genome-wide combined linkage-association scan of multiply phenotyped twin sibships(77)Centre for molecular-based causal analyses in health and disease(77)CHARGE consortium: gene discovery for CVD and aging phenotypes(76)A Genome-Wide Association Study in Essential Hypertension (FEHGAS2)(76)Validation and Replication of Genes Associated with Common Human Disease Using Australian Twin Families(74)NIMH Center for Collaborative Genetic Studies(73)A national DNA control series for genetic case-control studies based on the British 1958 birth cohort(73)Mapping Genes for typical migraine using twin families.(72)Cluster computing in genetic linkage studies on human complex traits(72)Epidemiology of Venous Thrombosis &Pulmonary Embolism(69)Dissecting genetic complexity of Alzheimer's disease and cognitive function(69)Genetics of melanoma risk factors(68)Genetics of melanoma risk factors(67)Twin-family database for behavior genetics and genomics studies(67)Cardiovascular diseases and psychiatric disorders in the general population: a prospective follow-up study(66)Association Screen of High Priority Positional Candidate Genes for Migraine(65)Assessment of biomedical risk factors and disease outcomes in the British 1958 cohort(65)Investigating the role of pigmentation pathway genes in moliness and melanoma risk(64)CHS Events Follow-up Study(61)CORONARY HEART DISEASE &STROKE IN THE ELDERLY(60)WGA Study to Identify Genetic Variants Associated with CV Events in CHS(60)AGES STUDY-THE REYKJAVIK STUDY OF HEALTHY AGING FOR THE NEW MILLENNIUM-260012100(59)Type 1 Diabetes Genetics Consortium(59)CORONARY HEART DISEASE AND STROKE(58)CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84(58)Statistical Methods and Algorithms for Analysis of High-throughput Genetics and Genomics Platforms(57)CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84(57)Research Fellowship - Grant ID:442915(55)UCLA Clinical and Translational Science Institute(55)CCSP - FIELD CENTER AND ULTRASOUND READING CENTER(55)CCSP-FIELD CENTER(53)BIOSHARE-EU(50)Develop & improve methodology in gene mapping, targetting localisation of genes underlying migraine & other disorders(50)COMMUNITY AND COHORT SURVEILLANCE PROGRAM(49)CCSP - FIELD CENTER(49)FIELD CENTER FOR CCSP(48)CANDIDATE GENE STUDIES OF OBESITY GUIDED BY WHOLE GENOME ASSOCIATION DATA(48)Integration of Genomics &Transcriptomics in Normal Twins &Major Depression(46)Candidate gene variation and the association between early growth and adult disease: studies in the 1966 Northern Finland Birth Cohort(46)CARDIOVASCULAR HEALTH STUDY--ECHOCARDIOGRAPHY(45)COMMUNITY AND COHORT SURVEILLANCE PROGRAMS(45)BBMRI-NL(45)PHASE(44)CENTRAL HEMOSTATIS LABORATORY FOR CCSP(44)MRI READING CENTER FOR THE CARDIOVASCULAR HEALTH STUDY(44)Understanding the genetic basis of common human diseases: core funding for the Wellcome Trust Centre for Human Genetics.(44)Maximising knowledge from dense SNP (single nucleotide polymorphisms) data using multi-locus analysis(43)Genetic analysis of type II diabetes in Finnish populati(43)Genome Wide Association Coordinating Center(43)Major Depression: Stage 1 Genomewide Association in Population-Based Samples(43)Wellcome Trust Sanger Institute - generic account for deposition of all core- funded research papers(43)Prospective meta-analyses of drug-gene interactions: CHARGE GWAS consortium(42)OPENGENE(41)ATHEROREMO(41)Identifying Genes for Type 2 Diabetes: FUSION(41)Exceptional aging: 12 year trajectories to function(41)Genome-wide association studies of biomedical traits and endophenotypes for complex disease(40)EURHEALTHAGEING(39)SUBCLINICAL CARDIOVASCULAR DISEASE COORDINATING CENTER-268995159(39)CORE--ADIPOSE TISSUE BIOLOGY AND BASIC MECHANISMS(39)CHS-ULTRASOUND READING(39)SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--EBCT READING(38)Identification of genetic risk factors for asthma: genome-wide association and the role of epigenetics(37)CHS RETINAL READING CENTER(37)TRIAL OF ASPIRIN AND VITAMIN E IN WOMEN(37)Cambridge Institute for Medical Research (CIMR).(37)VARIATION IN THE EFFECTS OF ALCOHOL ON LIVER FUNCTION(35)Locating genes for elementary and complex cognitive abilities using genetic linkage and association analysis(34)HYPERGENES(34)Genetics of common neurological diseases.(33)Genome-wide Association in Families: Data Integrity, Design and Methods Issue(32)Identification of genetic variants underlying coronary artery disease and associated phenotypes in Indian Asians.(32)Quantitative and Molecular Genetic Analysis of Cognition(31)AN NCRR CENTER FOR HIGH THROUGHPUT SNP GENOTYPING AND ANALYSIS: GAIN NETWORK(31)Genome-wide Search for CVD Gene-Environment Interactions(31)Cardiovascular diseases and psychiatric disorders in the general population: a prospective follow-up study(31)JH/CIDR Genotyping for Genome-Wide Association Studies(30)Molecular Epidemiology of Alcoholism 3 - EDAC Families(30)Genetic Architecture of Adiposity in Multiple Large Cohorts(30)DYNAMICS OF HEALTH .AGING . AND BODY COMPOSITION /Pittsburgh/-260962101(30)HEALTH ABC--COORDINATING UNIT-260962106(30)SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTER(30)WTCCC2 core activities.(30)
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External research report, Article, Report English OPENFTO, Type 2 Diabetes, and Weight Gain Throughout Adult Life: A Meta-Analysis of 41,504 Subjects From the Scandinavian HUNT, MDC, and MPP Studies
Hertel, Jens Kristoffer; Johansson, Stefan; Sonestedt, Emily; Jonsson, Anna; Lie, Rolv Terje; Platou, Carl G. P.; Nilsson, Peter M.; Rukh, Gull; Midthjell, Kristian; Hveem, Kristian; Melander, Olle; Groop, Leif; Lyssenko, Valeriya; Molven, Anders; Orho-Melander, Marju; ... (2011)Project: EC | ENGAGE (201413)This article contains Supplementary Data online at <a href="http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db10-1340/-/DC1" target="blank">http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db10-1340/-/DC1.</a> <p><strong>OBJECTIVE</strong>—... -
Article English OPENGenetic loci associated with coronary artery disease harbor evidence of selection and antagonistic pleiotropy.
Sean G Byars; Qin Qin Huang; Lesley-Ann Gray; Andrew Bakshi; Samuli Ripatti; Gad Abraham; Stephen C Stearns; Michael Inouye; (2017)Project: NIH | THE FRAMINGHAM HEART STUD... (N01HC025195-005), WT, NHMRC | Integrative genomics and ... (1062227), NHMRC | Large-Scale Multi-Omic An... (1090462), NHMRC | Using systems biology to ... (1061435), EC | ePerMed (692145), EC | ENGAGE (201413), EC | BIOSHARE-EU (261433)Traditional genome-wide scans for positive selection have mainly uncovered selective sweeps associated with monogenic traits. While selection on quantitative traits is much more common, very few signals have been detected because of their polygenic nature. We searched f... -
Article English OPENGenotype-driven recruitment: a strategy whose time has come?
Budin-Ljøsne, Isabelle; Soye, Kaitlin J; Tassé, Anne; Knoppers, Bartha; Harris, Jennifer R; (2013)Background Genotype-Driven Recruitment (GDR) is a research design that recruits research participants based on genotype rather than based on the presence or absence of a particular condition or clinical outcome. Analyses of the ethical issues of GDR studies, and the rec... -
Article English OPENExome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes
Altshuler, David; (2012)Project: EC | ENGAGE (201413), RCUK | Assessment of biomedical ... (G0000934), WT | The genetics of weight, B... (076113), WT | Statistical methods for t... (081682), WT | An investigation of genes... (083270), WT | The UK Type 2 diabetes ge... (072960)Aims/hypothesis Human complex metabolic traits are in part regulated by genetic determinants. Here we applied exome sequencing to identify novel associations of coding polymorphisms at minor allele frequencies (MAFs) >1% with common metabolic phenotypes. Methods The stu... -
Article, Other literature type English OPENGenome-wide association study identifies multiple loci influencing human serum metabolite levels
Kettunen, Johannes; Tukiainen, Taru; Sarin, Antti-Pekka; Ortega-Alonso, Alfredo; Tikkanen, Emmi; Lyytikainen, Leo-Pekka; Kangas, Antti J.; Soininen, Pasi; Wuertz, Peter; Silander, Kaisa; Dick, Danielle M.; Rose, Richard J.; Savolainen, Markku J.; Viikari, Jorma; Kahonen, Mika; ... (2012)Project: NIH | Genetics of cardiovascula... (5R01HL087679-02), NIH | Whole Genome Assoc. Analy... (5RL1MH083268-04), NIH | BEHAVIORAL PRECURSORS OF ... (5R01AA009203-04), NIH | ADOLESCENT ALCOHOL ABUSE:... (1R37AA012502-01), EC | BIOSHARE-EU (261433), EC | ENGAGE (201413), RCUK | Centre for molecular-base... (G0600705), WT | Candidate gene variation ... (069224), WT | Genetics of common neurol... (089062), WT | Wellcome Trust Sanger Ins... (098051)Nuclear magnetic resonance assays allow for measurement of a wide range of metabolic phenotypes. We report here the results of a GWAS on 8,330 Finnish individuals genotyped and imputed at 7.7 million SNPs for a range of 216 serum metabolic phenotypes assessed by NMR of ... -
Article, Other literature type English OPENGenetic predictors of fibrin D-dimer levels in healthy adults
Smith, Nicholas L.; Huffman, Jennifer E.; Strachan, David P.; Huang, Jie; Dehghan, Abbas; Trompet, Stella; Lopez, Lorna M.; Shin, So-Youn; Baumert, Jens; Vitart, Veronique; Bis, Joshua C.; Wild, Sarah H.; Rumley, Ann; Yang, Qiong; Uitterlinden, Andre G; ... (2011)Project: NIH | CHS-ULTRASOUND READING (N01HC045133-004), NIH | Type 1 Diabetes Genetics ... (1U01DK062418-01), NIH | CHS-Transition Phase -268... (N01HC055222-001), NIH | Epidemiology of Precursor... (5K24DK080140-03), NIH | CENTRAL BLOOD ANALYSIS LA... (N01HC085086-019), NIH | Diabetes Endocrinology Re... (3P30DK063491-04S1), NIH | INSULINOPENIC TYPE 2 DIAB... (5M01RR000425-40), NIH | MRI READING CENTER FOR TH... (N01HC015103-007), NIH | CORONARY HEART DISEASE AN... (N01HC085079-023), NIH | CARDIOVASCULAR HEALTH STU... (N01HC035129-010), EC | PHASE (223004), EC | ENGAGE (201413), NIH | CHS RETINAL READING CENTE... (N01HC075150-001), NWO | NCHA Subsidiebesluit 2008... (2300155116), RCUK | A genome-wide association... (BB/F019394/1), ...Background-Fibrin fragment D-dimer, one of several peptides produced when crosslinked fibrin is degraded by plasmin, is the most widely used clinical marker of activated blood coagulation. To identity genetic loci influencing D-dimer levels, we performed the first large... -
Article English CLOSEDComprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients
Saus, Ester; Brunet, Anna; Armengol, Lluís; Alonso, Pino; Crespo, José M.; Fernández-Aranda, Fernando; Guitart, Miriam; Martín-Santos, Rocío; Menchón, José Manuel; Navinés, Ricard; Soria, Virginia; Torrens, Marta; Urretavizcaya, Mikel; Vallès, Vicenç; Gratacòs, Mònica; ... (2010)Project: EC | ENGAGE (201413) -
Article English OPENA novel common variant in DCST2 is associated with length in early life and height in adulthood
van der Valk, R. J. P.; Kreiner-Moller, E.; Kooijman, M. N.; Guxens, M.; Stergiakouli, E.; Saaf, A.; Bradfield, J. P.; Geller, F.; Hayes, M. G.; Cousminer, D. L.; Korner, A.; Thiering, E.; Curtin, J. A.; Myhre, R.; Huikari, V.; ... (2015)Project: NIH | HAPO: DATA COORDINATING ... (5R01HD034242-04), NIH | Genome-wide association s... (3U01HG004423-02S1), NIH | Gene-Environment Interact... (5U01NS047537-04), NIH | HYPERGLYCEMIA AND ADVERSE... (1R01HD034243-01A2), NIH | Genome Wide Association S... (5R01HD056465-08), NIH | GWA Mapping: Maternal Met... (1U01HG004415-01), EC | ENGAGE (201413), EC | GMI (230374), NIH | A Center for GEI Associat... (5U01HG004424-02), NIH | Genome Wide Association C... (5U01HG004446-04), NHMRC | Childhood Precursors of A... (403981), NIH | JH/CIDR Genotyping for Ge... (5U01HG004438-04), NIH | Replication of GWAS for M... (1R01CA141688-01), WT | Wellcome Trust Sanger Ins... (098051), WT | Understanding the genetic... (090532), ...Common genetic variants have been identified for adult height, but not much is known about the genetics of skeletal growth in early life. To identify common genetic variants that influence fetal skeletal growth, we meta-analyzed 22 genome-wide association studies (Stage... -
Article English OPENQuantification of the smoking-associated cancer risk with rate advancement periods: meta-analysis of individual participant data from cohorts of the CHANCES consortium
Ordóñez-Mena, José Manuel; Schöttker, Ben; Mons, Ute; Jenab, Mazda; Freisling, Heinz; Bueno-de-Mesquita, Bas; O’Doherty, Mark G.; Scott, Angela; Kee, Frank; Stricker, Bruno H.; Hofman, Albert; de Keyser, Catherine E.; Ruiter, Rikje; Söderberg, Stefan; Jousilahti, Pekka; ... (2016)Project: EC | CHANCES (242244), EC | BIOMARCARE (278913), EC | ENGAGE (201413), WT | Determinants of cardiovas... (081081), WT | Determinants of cardiovas... (064947), NIH | Health disparities and ag... (5R01AG023522-04)Source: <a href=http://dx.doi.org/10.1186/s12916-016-0607-5>doi: 10.1186/s12916-016-0607-5</a> Background:<br> Smoking is the most important individual risk factor for many cancer sites but its association with breast and prostate cancer is not entirely clear. Ra... -
Article English OPENWorldwide population distribution of the common LCE3C-LCE3B deletion associated with psoriasis and other autoimmune disorders
Bassaganyas, Laia; Riveira-Munoz, Eva; Garcia-Aragones, Manel; Gonzalez, Juan R.; Caceres, Mario; Armengol, Lluis; Estivill, Xavier; (2013)Project: EC | ENGAGE (201413)Background: There is increasing evidence of the importance of copy number variants (CNV) in genetic diversity among individuals and populations, as well as in some common genetic diseases. We previously characterized a common 32-kb insertion/deletion variant of the PSOR...