Loading
Filter By:
-
Funder (14)
European Commission(542)Wellcome Trust(336)National Institutes of Health(310)Netherlands Organisation for Scientific Research (NWO)(192)Research Council UK(146)National Health and Medical Research Council (NHMRC)(126)Swiss National Science Foundation(73)Australian Research Council (ARC)(57)Austrian Science Fund (FWF)(17)Croatian Science Foundation (CSF)(16)Ministry of Science, Education and Sports of the Republic of Croatia (MSES)(13)National Science Foundation(11)Fundação para a Ciência e a Tecnologia, I.P.(3)Science Foundation Ireland(3)
-
Project (99+)
ENGAGE(542)NCHA Subsidiebesluit 2008-2012(115)Genetics of cardiovascular risk factors in large founder population birth control(98)Whole Genome Assoc. Analysis Strategies for Multi. Phenotypes(85)GMI(82)THE FRAMINGHAM HEART STUDY-268025195(81)Genetic Influences on ADHD in a Finnish Birth Cohort(72)GEFOS(65)tweeling onderzoek, met een focus op gedrag en depressie(65)Institute for Clinical and Translational Research (UL1)(63)Centre for molecular-based causal analyses in health and disease(63)Genome-wide combined linkage-association scan of multiply phenotyped twin sibships(61)GWA for Gene-Environment Interaction Effects Influencing CHD(61)Genome-Wide Association for Loci Influencing CHD and Other Heart, Lung and Blood(59)Cluster computing in genetic linkage studies on human complex traits(59)CORONARY HEART DISEASE AND STROKE(58)Validation and Replication of Genes Associated with Common Human Disease Using Australian Twin Families(57)Twin-family database for behavior genetics and genomics studies(57)Mapping Genes for typical migraine using twin families.(55)CENTRAL BLOOD ANALYSIS LABORATORY FOR CHS(55)CHS-Transition Phase -268055222(55)The genetics of weight, BMI, adiposity and obesity(55)Genetics of melanoma risk factors(54)Genetics of melanoma risk factors(53)Association Screen of High Priority Positional Candidate Genes for Migraine(53)NIMH Center for Collaborative Genetic Studies(53)A Genome-Wide Association Study in Essential Hypertension (FEHGAS2)(53)Dissecting genetic complexity of Alzheimer's disease and cognitive function(53)Epidemiology of Venous Thrombosis &Pulmonary Embolism(50)Assessment of biomedical risk factors and disease outcomes in the British 1958 cohort(50)Investigating the role of pigmentation pathway genes in moliness and melanoma risk(49)CHARGE consortium: gene discovery for CVD and aging phenotypes(48)Cardiovascular diseases and psychiatric disorders in the general population: a prospective follow-up study(47)A national DNA control series for genetic case-control studies based on the British 1958 birth cohort(47)Research Fellowship - Grant ID:442915(44)Develop & improve methodology in gene mapping, targetting localisation of genes underlying migraine & other disorders(44)Statistical Methods and Algorithms for Analysis of High-throughput Genetics and Genomics Platforms(44)AGES STUDY-THE REYKJAVIK STUDY OF HEALTHY AGING FOR THE NEW MILLENNIUM-260012100(42)BIOSHARE-EU(39)Major Depression: Stage 1 Genomewide Association in Population-Based Samples(39)Type 1 Diabetes Genetics Consortium(38)BBMRI-NL(38)CORONARY HEART DISEASE AND STROKE(37)Wellcome Trust Sanger Institute - generic account for deposition of all core- funded research papers(37)Genome-wide association studies of biomedical traits and endophenotypes for complex disease(36)CORONARY HEART DISEASE &STROKE IN THE ELDERLY(36)CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84(36)CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84(35)CHS Events Follow-up Study(35)Candidate gene variation and the association between early growth and adult disease: studies in the 1966 Northern Finland Birth Cohort(35)Identification of genetic risk factors for asthma: genome-wide association and the role of epigenetics(34)Understanding the genetic basis of common human diseases: core funding for the Wellcome Trust Centre for Human Genetics.(34)OPENGENE(33)Integration of Genomics &Transcriptomics in Normal Twins &Major Depression(33)CCSP-FIELD CENTER(32)CCSP - FIELD CENTER AND ULTRASOUND READING CENTER(32)WGA Study to Identify Genetic Variants Associated with CV Events in CHS(32)COMMUNITY AND COHORT SURVEILLANCE PROGRAM(31)UCLA Clinical and Translational Science Institute(31)MRI READING CENTER FOR THE CARDIOVASCULAR HEALTH STUDY(30)CCSP - FIELD CENTER(30)Maximising knowledge from dense SNP (single nucleotide polymorphisms) data using multi-locus analysis(29)PHASE(29)CARDIOVASCULAR HEALTH STUDY--ECHOCARDIOGRAPHY(29)FIELD CENTER FOR CCSP(29)CHS RETINAL READING CENTER(29)Locating genes for elementary and complex cognitive abilities using genetic linkage and association analysis(28)Quantitative and Molecular Genetic Analysis of Cognition(28)EURHEALTHAGEING(26)Genetic analysis of type II diabetes in Finnish populati(26)COMMUNITY AND COHORT SURVEILLANCE PROGRAMS(26)Genome Wide Association Coordinating Center(26)Molecular Epidemiology of Alcoholism 3 - EDAC Families(26)VARIATION IN THE EFFECTS OF ALCOHOL ON LIVER FUNCTION(26)CANDIDATE GENE STUDIES OF OBESITY GUIDED BY WHOLE GENOME ASSOCIATION DATA(26)CHS-ULTRASOUND READING(26)Cambridge Institute for Medical Research (CIMR).(26)Genetics of common neurological diseases.(26)ATHEROREMO(25)CENTRAL HEMOSTATIS LABORATORY FOR CCSP(25)Identifying Genes for Type 2 Diabetes: FUSION(25)Molecular Epidemiology of Alcoholism 2- Big Sibships(25)Prospective meta-analyses of drug-gene interactions: CHARGE GWAS consortium(25)Molecular Epidemiology of Alcoholism 1--Candidate Gene(25)WTCCC2 core activities.(25)HYPERGENES(24)CORE--ADIPOSE TISSUE BIOLOGY AND BASIC MECHANISMS(24)PERSISTENCE &CHANGE IN DRINKING HABITS: TWIN STUDY(24)SUBCLINICAL CARDIOVASCULAR DISEASE COORDINATING CENTER-268995159(23)JH/CIDR Genotyping for Genome-Wide Association Studies(23)SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--EBCT READING(23)Genomics of Developmental Trajectories in Twins(23)Bayesian Discovery of Regression Structures: a tool kit for genetic epidemiology and integrative genomics analyses(22)Identification of genetic variants underlying coronary artery disease and associated phenotypes in Indian Asians.(22)Diabetes Endocrinology Research Center(21)Exceptional aging: 12 year trajectories to function(21)TRIAL OF ASPIRIN AND VITAMIN E IN WOMEN(21)International Collaborative Twin Study of Refractive and Glaucoma Endophenotypes(21)Genome-wide Search for CVD Gene-Environment Interactions(21)
-
Publication Date (11)
2012(99)2013(77)2011(75)2014(51)2010(50)2017(50)2015(42)2009(32)2016(32)2018(20)2008(9)
-
Access Mode (3)
Open Access(484)Closed Access(55)Restricted(3)
-
Type (10)
Article(533)Other literature type(128)Unknown(68)Preprint(11)Review(11)Doctoral thesis(3)Conference object(1)External research report(1)Other ORP type(1)Report(1)
-
Language (2)
English(523)Undetermined(14)
-
Community (2)
EGI Federation(17)FET FP7(1)
-
Content Provider (100+)
Europe PubMed Central(380)Unknown Repository(335)Erasmus University Institutional Repository(85)Edinburgh Research Explorer(83)Digital Access to Scholarship at Harvard(52)UCL Discovery(48)Spiral - Imperial College Digital Repository(45)DSpace at VU(40)SpringerOpen(33)Serveur académique lausannois(31)University of Groningen Digital Archive(29)Enlighten(27)St George's Online Research Archive(26)PLoS ONE(24)King's Research Portal(24)LSHTM Research Online(23)Publikationer från Uppsala Universitet(23)TamPub Julkaisuarkisto - TamPub Institutional Repository(21)Oxford University Research Archive(20)Open Access LMU(17)Explore Bristol Research(17)BASE (Open Access Aggregator)(16)Radboud Repository(15)Archive ouverte UNIGE(15)Queen's University Research Portal(14)Copenhagen University Research Information System(13)NTNU Open(13)Online Research @ Cardiff(13)Norwegian Open Research Archives(12)Lund University Publications(12)PLoS Genetics(10)Helsingin yliopiston digitaalinen arkisto(10)University of Southern Denmark Research Output(10)Ghent University Academic Bibliography(10)Hyper Article en Ligne(9)INRIA a CCSD electronic archive server(9)University of Liverpool Repository(8)Brunel University Research Archive(8)bioRxiv(8)Landspítali University Hospital Research Archive(7)Publikationer från Umeå universitet(7)Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano(6)Trinity's Access to Research Archive(6)Apollo(6)DSpace@MIT(6)Utrecht University Repository(6)eScholarship - University of California(6)Juelich Shared Electronic Resources(6)UPF Digital Repository(6)University of Lincoln Institutional Repository(6)Lirias(6)HAL-Inserm(5)MediaTUM(5)BMC Genomics(4)Translational Psychiatry(4)Norsk Epidemiologi(4)e-Prints Soton(4)UEF eRepository(4)Wageningen Yield(4)BMC Bioinformatics(3)BMC Medical Genomics(3)Scientific Reports(3)Hal-Diderot(3)Keele Research Repository(3)HAL AMU(3)Aaltodoc Publication Archive(3)Research Repository of Catalonia(3)Opin visindi(3)edoc(3)Archivio istituzionale della ricerca - Università dell'Insubria(3)Nottingham ePrints(3)HAL-UPMC(3)University of Oulu Repository - Jultika(3)Publikationer från Högskolan i Jönköping(3)UM Publications(3)Nucleic Acids Research(2)BMC Medical Genetics(2)OPUS FAU - Online-Publikationssystem der Friedrich-Alexander-Universität Erlangen-Nürnberg(2)Zurich Open Repository and Archive(2)HAL-Rennes 1(2)Diposit Digital de la Universitat de Barcelona(2)Kingston University Research Repository(2)HAL-CEA(2)Archivio istituzionale della ricerca - Università di Trieste(2)arXiv.org e-Print Archive(2)Nottingham eTheses(2)Cork Open Research Archive(2)Open Repository and Bibliography - University of Liège(2)RERO DOC Digital Library(2)Archivio Istituzionale(2)Universiteit Twente Repository(2)e-publications@RCSI(2)BOA - Bicocca Open Archive(2)Central Archive at the University of Reading(2)Universiteit van Amsterdam Digital Academic Repository(2)Digital.CSIC(2)HKU Scholars Hub(2)Munin - Open Research Archive(2)Journal of the Renin-Angiotensin-Aldosterone System(1)Aging Cell(1)
-
Funder (14)
European Commission(542)Wellcome Trust(336)National Institutes of Health(310)Netherlands Organisation for Scientific Research (NWO)(192)View moreResearch Council UK(146)Funder
European Commission(542)Wellcome Trust(336)National Institutes of Health(310)Netherlands Organisation for Scientific Research (NWO)(192)Research Council UK(146)National Health and Medical Research Council (NHMRC)(126)Swiss National Science Foundation(73)Australian Research Council (ARC)(57)Austrian Science Fund (FWF)(17)Croatian Science Foundation (CSF)(16)Ministry of Science, Education and Sports of the Republic of Croatia (MSES)(13)National Science Foundation(11)Fundação para a Ciência e a Tecnologia, I.P.(3)Science Foundation Ireland(3)
-
Project (99+)
ENGAGE(542)NCHA Subsidiebesluit 2008-2012(115)Genetics of cardiovascular risk factors in large founder population birth control(98)Whole Genome Assoc. Analysis Strategies for Multi. Phenotypes(85)View moreGMI(82)Project
Showing top 99 values.ENGAGE(542)
NCHA Subsidiebesluit 2008-2012(115)Genetics of cardiovascular risk factors in large founder population birth control(98)Whole Genome Assoc. Analysis Strategies for Multi. Phenotypes(85)GMI(82)THE FRAMINGHAM HEART STUDY-268025195(81)Genetic Influences on ADHD in a Finnish Birth Cohort(72)GEFOS(65)tweeling onderzoek, met een focus op gedrag en depressie(65)Institute for Clinical and Translational Research (UL1)(63)Centre for molecular-based causal analyses in health and disease(63)Genome-wide combined linkage-association scan of multiply phenotyped twin sibships(61)GWA for Gene-Environment Interaction Effects Influencing CHD(61)Genome-Wide Association for Loci Influencing CHD and Other Heart, Lung and Blood(59)Cluster computing in genetic linkage studies on human complex traits(59)CORONARY HEART DISEASE AND STROKE(58)Validation and Replication of Genes Associated with Common Human Disease Using Australian Twin Families(57)Twin-family database for behavior genetics and genomics studies(57)Mapping Genes for typical migraine using twin families.(55)CENTRAL BLOOD ANALYSIS LABORATORY FOR CHS(55)CHS-Transition Phase -268055222(55)The genetics of weight, BMI, adiposity and obesity(55)Genetics of melanoma risk factors(54)Genetics of melanoma risk factors(53)Association Screen of High Priority Positional Candidate Genes for Migraine(53)NIMH Center for Collaborative Genetic Studies(53)A Genome-Wide Association Study in Essential Hypertension (FEHGAS2)(53)Dissecting genetic complexity of Alzheimer's disease and cognitive function(53)Epidemiology of Venous Thrombosis &Pulmonary Embolism(50)Assessment of biomedical risk factors and disease outcomes in the British 1958 cohort(50)Investigating the role of pigmentation pathway genes in moliness and melanoma risk(49)CHARGE consortium: gene discovery for CVD and aging phenotypes(48)Cardiovascular diseases and psychiatric disorders in the general population: a prospective follow-up study(47)A national DNA control series for genetic case-control studies based on the British 1958 birth cohort(47)Research Fellowship - Grant ID:442915(44)Develop & improve methodology in gene mapping, targetting localisation of genes underlying migraine & other disorders(44)Statistical Methods and Algorithms for Analysis of High-throughput Genetics and Genomics Platforms(44)AGES STUDY-THE REYKJAVIK STUDY OF HEALTHY AGING FOR THE NEW MILLENNIUM-260012100(42)BIOSHARE-EU(39)Major Depression: Stage 1 Genomewide Association in Population-Based Samples(39)Type 1 Diabetes Genetics Consortium(38)BBMRI-NL(38)CORONARY HEART DISEASE AND STROKE(37)Wellcome Trust Sanger Institute - generic account for deposition of all core- funded research papers(37)Genome-wide association studies of biomedical traits and endophenotypes for complex disease(36)CORONARY HEART DISEASE &STROKE IN THE ELDERLY(36)CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84(36)CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84(35)CHS Events Follow-up Study(35)Candidate gene variation and the association between early growth and adult disease: studies in the 1966 Northern Finland Birth Cohort(35)Identification of genetic risk factors for asthma: genome-wide association and the role of epigenetics(34)Understanding the genetic basis of common human diseases: core funding for the Wellcome Trust Centre for Human Genetics.(34)OPENGENE(33)Integration of Genomics &Transcriptomics in Normal Twins &Major Depression(33)CCSP-FIELD CENTER(32)CCSP - FIELD CENTER AND ULTRASOUND READING CENTER(32)WGA Study to Identify Genetic Variants Associated with CV Events in CHS(32)COMMUNITY AND COHORT SURVEILLANCE PROGRAM(31)UCLA Clinical and Translational Science Institute(31)MRI READING CENTER FOR THE CARDIOVASCULAR HEALTH STUDY(30)CCSP - FIELD CENTER(30)Maximising knowledge from dense SNP (single nucleotide polymorphisms) data using multi-locus analysis(29)PHASE(29)CARDIOVASCULAR HEALTH STUDY--ECHOCARDIOGRAPHY(29)FIELD CENTER FOR CCSP(29)CHS RETINAL READING CENTER(29)Locating genes for elementary and complex cognitive abilities using genetic linkage and association analysis(28)Quantitative and Molecular Genetic Analysis of Cognition(28)EURHEALTHAGEING(26)Genetic analysis of type II diabetes in Finnish populati(26)COMMUNITY AND COHORT SURVEILLANCE PROGRAMS(26)Genome Wide Association Coordinating Center(26)Molecular Epidemiology of Alcoholism 3 - EDAC Families(26)VARIATION IN THE EFFECTS OF ALCOHOL ON LIVER FUNCTION(26)CANDIDATE GENE STUDIES OF OBESITY GUIDED BY WHOLE GENOME ASSOCIATION DATA(26)CHS-ULTRASOUND READING(26)Cambridge Institute for Medical Research (CIMR).(26)Genetics of common neurological diseases.(26)ATHEROREMO(25)CENTRAL HEMOSTATIS LABORATORY FOR CCSP(25)Identifying Genes for Type 2 Diabetes: FUSION(25)Molecular Epidemiology of Alcoholism 2- Big Sibships(25)Prospective meta-analyses of drug-gene interactions: CHARGE GWAS consortium(25)Molecular Epidemiology of Alcoholism 1--Candidate Gene(25)WTCCC2 core activities.(25)HYPERGENES(24)CORE--ADIPOSE TISSUE BIOLOGY AND BASIC MECHANISMS(24)PERSISTENCE &CHANGE IN DRINKING HABITS: TWIN STUDY(24)SUBCLINICAL CARDIOVASCULAR DISEASE COORDINATING CENTER-268995159(23)JH/CIDR Genotyping for Genome-Wide Association Studies(23)SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--EBCT READING(23)Genomics of Developmental Trajectories in Twins(23)Bayesian Discovery of Regression Structures: a tool kit for genetic epidemiology and integrative genomics analyses(22)Identification of genetic variants underlying coronary artery disease and associated phenotypes in Indian Asians.(22)Diabetes Endocrinology Research Center(21)Exceptional aging: 12 year trajectories to function(21)TRIAL OF ASPIRIN AND VITAMIN E IN WOMEN(21)International Collaborative Twin Study of Refractive and Glaucoma Endophenotypes(21)Genome-wide Search for CVD Gene-Environment Interactions(21)
-
Publication Date (11)
2012(99)2013(77)2011(75)2014(51)View more2010(50)Publication Date
2012(99)2013(77)2011(75)2014(51)2010(50)2017(50)2015(42)2009(32)2016(32)2018(20)2008(9)
-
Access Mode (3)
Open Access(484)Closed Access(55)Restricted(3)Access Mode
Open Access(484)Closed Access(55)Restricted(3)
-
Type (10)
Article(533)Other literature type(128)Unknown(68)Preprint(11)View moreReview(11)Type
Article(533)Other literature type(128)Unknown(68)Preprint(11)Review(11)Doctoral thesis(3)Conference object(1)External research report(1)Other ORP type(1)Report(1)
-
Language (2)
English(523)Undetermined(14)Language
English(523)Undetermined(14)
-
Community (2)
EGI Federation(17)FET FP7(1)Community
EGI Federation(17)FET FP7(1)
-
Content Provider (100+)
Europe PubMed Central(380)Unknown Repository(335)Erasmus University Institutional Repository(85)Edinburgh Research Explorer(83)View moreDigital Access to Scholarship at Harvard(52)Content Provider
Showing top 100 values.Europe PubMed Central(380)Unknown Repository(335)Erasmus University Institutional Repository(85)Edinburgh Research Explorer(83)Digital Access to Scholarship at Harvard(52)UCL Discovery(48)Spiral - Imperial College Digital Repository(45)DSpace at VU(40)SpringerOpen(33)Serveur académique lausannois(31)University of Groningen Digital Archive(29)Enlighten(27)St George's Online Research Archive(26)PLoS ONE(24)King's Research Portal(24)LSHTM Research Online(23)Publikationer från Uppsala Universitet(23)TamPub Julkaisuarkisto - TamPub Institutional Repository(21)Oxford University Research Archive(20)Open Access LMU(17)Explore Bristol Research(17)BASE (Open Access Aggregator)(16)Radboud Repository(15)Archive ouverte UNIGE(15)Queen's University Research Portal(14)Copenhagen University Research Information System(13)NTNU Open(13)Online Research @ Cardiff(13)Norwegian Open Research Archives(12)Lund University Publications(12)PLoS Genetics(10)Helsingin yliopiston digitaalinen arkisto(10)University of Southern Denmark Research Output(10)Ghent University Academic Bibliography(10)Hyper Article en Ligne(9)INRIA a CCSD electronic archive server(9)University of Liverpool Repository(8)Brunel University Research Archive(8)bioRxiv(8)Landspítali University Hospital Research Archive(7)Publikationer från Umeå universitet(7)Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano(6)Trinity's Access to Research Archive(6)Apollo(6)DSpace@MIT(6)Utrecht University Repository(6)eScholarship - University of California(6)Juelich Shared Electronic Resources(6)UPF Digital Repository(6)University of Lincoln Institutional Repository(6)Lirias(6)HAL-Inserm(5)MediaTUM(5)BMC Genomics(4)Translational Psychiatry(4)Norsk Epidemiologi(4)e-Prints Soton(4)UEF eRepository(4)Wageningen Yield(4)BMC Bioinformatics(3)BMC Medical Genomics(3)Scientific Reports(3)Hal-Diderot(3)Keele Research Repository(3)HAL AMU(3)Aaltodoc Publication Archive(3)Research Repository of Catalonia(3)Opin visindi(3)edoc(3)Archivio istituzionale della ricerca - Università dell'Insubria(3)Nottingham ePrints(3)HAL-UPMC(3)University of Oulu Repository - Jultika(3)Publikationer från Högskolan i Jönköping(3)UM Publications(3)Nucleic Acids Research(2)BMC Medical Genetics(2)OPUS FAU - Online-Publikationssystem der Friedrich-Alexander-Universität Erlangen-Nürnberg(2)Zurich Open Repository and Archive(2)HAL-Rennes 1(2)Diposit Digital de la Universitat de Barcelona(2)Kingston University Research Repository(2)HAL-CEA(2)Archivio istituzionale della ricerca - Università di Trieste(2)arXiv.org e-Print Archive(2)Nottingham eTheses(2)Cork Open Research Archive(2)Open Repository and Bibliography - University of Liège(2)RERO DOC Digital Library(2)Archivio Istituzionale(2)Universiteit Twente Repository(2)e-publications@RCSI(2)BOA - Bicocca Open Archive(2)Central Archive at the University of Reading(2)Universiteit van Amsterdam Digital Academic Repository(2)Digital.CSIC(2)HKU Scholars Hub(2)Munin - Open Research Archive(2)Journal of the Renin-Angiotensin-Aldosterone System(1)Aging Cell(1)
-
Article English OPENExome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes
Albrechtsen, Anders; Grarup, N; Li, Y; Sparsø, Thomas Hempel; Tian, G; Cao, H; Jiang, Tao; Kim, S Y; Korneliussen, Thorfinn Sand; Li, Q; Nie, C; Wu, Rui; Skotte, Line; Morris, A P; Ladenvall, C; ... (2013)Project: WT | The genetics of weight, B... (076113), WT | An investigation of genes... (083270), WT | Statistical methods for t... (081682), WT | The UK Type 2 diabetes ge... (072960), RCUK | Assessment of biomedical ... (G0000934), EC | ENGAGE (201413)Aims/hypothesis Human complex metabolic traits are in part regulated by genetic determinants. Here we applied exome sequencing to identify novel associations of coding polymorphisms at minor allele frequencies (MAFs) >1% with common metabolic phenotypes. Methods The stu... -
Article English OPENInterspecies Translation of Disease Networks Increases Robustness and Predictive Accuracy
Anvar, SY; Tucker, A; Vinciotti, V; Venema, A; van Ommen, G-JB; van der Maarel, SM; Raz, V; 't Hoen, PAC; (2011)Project: EC | ENGAGE (201413)© 2011 Anvar et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Gene regula... -
Article English OPENQuality, quantity and harmony: the DataSHaPER approach to integrating data across bioclinical studies.
Fortier, I.; Burton, P. R.; Robson, P. J.; Ferretti, V.; Little, J.; L'Heureux, F.; Deschenes, M.; Knoppers, B. M.; Doiron, D.; Keers, J. C.; Linksted, P.; Harris, J. R.; Lachance, G.; Boileau, C.; Pedersen, N. L.; ... (2010)Background Vast sample sizes are often essential in the quest to disentangle the complex interplay of the genetic, lifestyle, environmental and social factors that determine the aetiology and progression of chronic diseases. The pooling of information between studies is... -
Article, Unknown English OPENGenome metabolome integrated network analysis to uncover connections between genetic variants and complex traits: an application to obesity
Valcárcel, Beatriz; Ebbels, Timothy M. D.; Kangas, Antti J.; Soininen, Pasi; Elliot, Paul; Ala-Korpela, Mika; Järvelin, Marjo-Riitta; de Iorio, Maria; (2014)Project: EC | COSMOS (312941), EC | DIXA (283775), EC | ENGAGE (201413), RCUK | Centre for molecular-base... (G0600705), NIH | Whole Genome Assoc. Analy... (1RL1MH083268-01), NIH | Genetics of cardiovascula... (5R01HL087679-02), NIH | Genetic Influences on ADH... (1R01MH063706-01)Current studies of phenotype diversity by genome-wide association studies (GWAS) are mainly focused on identifying genetic variants that influence level changes of individual traits without considering additional alterations at the system-level. However, in addition to ... -
Article, Other literature type English OPENA novel atlas of gene expression in human skeletal muscle reveals molecular changes associated with aging
Su, Jing; Ekman, Carl; Oskolkov, Nikolay; Lahti, Leo; Ström, Kristoffer; Brazma, Alvis; Groop, Leif; Rung, Johan; Hansson, Ola; (2015)Background Although high-throughput studies of gene expression have generated large amounts of data, most of which is freely available in public archives, the use of this valuable resource is limited by computational complications and non-homogenous annotation. To addre... -
Unknown, Article, Other literature type English OPENThirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies
Elks, Cathy E; Perry, John R B; Sulem, Patrick; Chasman, Daniel I; Franceschini, Nora; He, Chunyan; Lunetta, Kathryn L; Visser, Jenny A; Byrne, Enda M; Cousminer, Diana L; Gudbjartsson, Daniel F; Esko, Tõnu; Feenstra, Bjarke; Hottenga, Jouke-Jan; Koller, Daniel L; ... (2010)Project: RCUK | Assessment of biomedical ... (G0000934), SNSF | Contribution of the nucle... (310030_122586), SNSF | Cardiovascular diseases a... (33CSC0-122661), WT | ALSPAC: consolidation of ... (076467), WT | Cambridge Institute for M... (079895), WT | A national DNA control se... (068545), WT | Genetic studies of the ae... (077016), NWO | NCHA Subsidiebesluit 2008... (2300155116), NWO | Twin-family database for ... (2200125679), NWO | Cluster computing in gene... (2300131050), SNSF | From modules to models: t... (31003A-116323), NIH | GWAS of Venous Thrombosis (1U01HG004735-01), NIH | Genetic Risk to Stroke in... (5U01HG004436-02), NIH | Building on GWAS for NHLB... (1RC2HL102419-01), NIH | Genome-wide Association i... (5U01HL084756-03), ...<p>To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at LIN28B (P = 5.4 x 10(-60)) and 9q31.2 (P = 2.2 x 10(... -
Article English OPENGenotype-driven recruitment: a strategy whose time has come?
Budin-Ljøsne, Isabelle; Soye, Kaitlin J; Tassé, Anne; Knoppers, Bartha; Harris, Jennifer R; (2013)Background Genotype-Driven Recruitment (GDR) is a research design that recruits research participants based on genotype rather than based on the presence or absence of a particular condition or clinical outcome. Analyses of the ethical issues of GDR studies, and the rec... -
Article, Other literature type English OPENGenome-wide association study identifies multiple loci influencing human serum metabolite levels
Kettunen, Johannes; Tukiainen, Taru; Sarin, Antti-Pekka; Ortega-Alonso, Alfredo; Tikkanen, Emmi; Lyytikäinen, Leo-Pekka; Kangas, Antti J; Soininen, Pasi; Würtz, Peter; Silander, Kaisa; Dick, Danielle M; Rose, Richard J; Savolainen, Markku J; Viikari, Jorma; Kähönen, Mika; ... (2012)Project: NIH | Genetics of cardiovascula... (5R01HL087679-02), EC | BIOSHARE-EU (261433), NIH | ADOLESCENT ALCOHOL ABUSE:... (1R37AA012502-01), EC | ENGAGE (201413), NIH | BEHAVIORAL PRECURSORS OF ... (5R01AA009203-04), NIH | Whole Genome Assoc. Analy... (5RL1MH083268-04), WT | Genetics of common neurol... (089062), WT | Wellcome Trust Sanger Ins... (098051), WT | Candidate gene variation ... (069224), RCUK | Centre for molecular-base... (G0600705)Nuclear magnetic resonance assays allow for measurement of a wide range of metabolic phenotypes. We report here the results of a GWAS on 8,330 Finnish individuals genotyped and imputed at 7.7 million SNPs for a range of 216 serum metabolic phenotypes assessed by NMR of ... -
Article, Other literature type English OPENTwin's Birth-Order Differences in Height and Body Mass Index From Birth to Old Age: A Pooled Study of 26 Twin Cohorts Participating in the CODATwins Project
Yokoyama, Yoshie; Jelenkovic, Aline; Sund, Reijo; Sung, Joohon; Hopper, John L.; Ooki, Syuichi; Heikkilä, Kauko; Aaltonen, Sari; Tarnoki, Adam D.; Tarnoki, David L.; Willemsen, Gonneke; Bartels, Meike; Van Beijsterveldt, Toos C. E. M.; Saudino, Kimberly J.; Cutler, Tessa L.; ... (2016)Project: RCUK | Origins of learning diffi... (G0901245), NIH | Genetic Influences on Act... (1R01MH062375-01A2), NIH | HEALTH AND PSYCHOSOCIAL F... (5R01AG013662-03), NIH | Integrating contextual, p... (3R01HD066040-04S1), NIH | Familial Transmission of ... (1R03MH063851-01A1), NHMRC | Mental Health Across Gene... (437015), NHMRC | Defining genetic and epig... (607358), NHMRC | Australian Centre of Exce... (1079102), EC | ENGAGE (201413), NIH | The Effects of Estradiol ... (5R01MH092377-03), NIH | Gene-environment Interact... (5R01MH081813-04), NIH | Developmental Change in T... (5R01HD068435-04)<p>We analyzed birth order differences in means and variances of height and body mass index (BMI) in monozygotic (MZ) and dizygotic (DZ) twins from infancy to old age. The data were derived from the international CODATwins database. The total number of height and BMI me... -
Article English OPENGenome-wide association identifies ATOH7 as a major gene determining human optic disc size
Macgregor, Stuart; Hewitt, Alex W.; Hysi, Pirro G.; Ruddle, Jonathan B.; Medland, Sarah E.; Henders, Anjali K.; Gordon, Scott D.; Andrew, Toby; McEvoy, Brian; Sanfilippo, Paul G.; Carbonaro, Francis; Tah, Vikas; Li, Yi Ju; Bennett, Sonya L.; Craig, Jamie E.; ... (2010)Project: NWO | Cluster computing in gene... (2300131050), WT, NIH | INVESTIGATION OF MAMMALIA... (5R01EY013612-04), EC | GEFOS (201865), EC | ENGAGE (201413), NIH | International Collaborati... (5R01EY018246-03)Optic nerve assessment is important for many blinding diseases, with cup-to-disc ratio (CDR) assessments commonly used in both diagnosis and progression monitoring of glaucoma patients. Optic disc, cup, rim area and CDR measurements all show substantial variation betwee...