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710 publications, page 1 of 71

Metabolomic markers reveal novel pathways of ageing and early development in human populations
Article English OPEN
Menni, Cristina; Kastenmueller, Gabriella; Petersen, Ann Kristin; Bell, Jordana T.; Psatha, Maria; Tsai, Pei-Chien; Gieger, Christian; Schulz, Holger; Erte, Idil; John, Sally; Brosnan, M. Julia; Wilson, Scott G.; Tsaprouni, Loukia; Lim, Ee Mun; Stuckey, Bronwyn; ...
(2013)
Publisher: OXFORD UNIV PRESS

Project: WT | Wellcome Trust Sanger Ins... (098051), EC | EPITWIN (250157), EC | ENGAGE (201413), EC | EURHEALTHAGEING (277849)
Background Human ageing is a complex, multifactorial process and early developmental factors affect health outcomes in old age. Methods Metabolomic profiling on fasting blood was carried out in 6055 individuals from the UK. Stepwise regression was performed to identify ...
Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases
Article English OPEN
Perry, John; Voight, Benjamin; Yengo, Loic; Amin, Najaf; Dupuis, Josée; Ganser, Martha; Grallert, Harald; Navarro, Pau; Li, Man; Qi, Lu; Steinthorsdottir, Valgerdur; Scott, Robert; Almgren, Peter; Arking, Dan; Aulchenko, Yurii; ...
(2012)

Project: NIH | GWAS of Venous Thrombosis (1U01HG004735-01), RCUK | Translating genome-wide a... (G0601261), WT | Identifying low frequency... (092447), WT | An investigation of genes... (083270), NIH | A Whole Genome Admixture ... (3R01CA063464-09S1), NIH | International Consortium ... (1U01DE018993-01), NIH | Dental Caries: Whole Geno... (3U01DE018903-02S1), NIH | GWA Mapping: Maternal Met... (1U01HG004415-01), NIH | GWA for Gene-Environment ... (5U01HG004402-02), NIH | THE FRAMINGHAM HEART STUD... (N01HC025195-005), NIH | Genome-Wide Associations ... (1U01HG004738-01), NIH | MULTIETHNIC/MINORITY COHO... (5R01CA054281-03), NIH | Targeted Genetic Analysis... (2R01DK072193-10), NIH | A Genome-wide Association... (5U01CA136792-02), NIH | GWAS of longitudinal bloo... (1U01HG004729-01),...
textabstractCommon diseases such as type 2 diabetes are phenotypically heterogeneous. Obesity is a major risk factor for type 2 diabetes, but patients vary appreciably in body mass index. We hypothesized that the genetic predisposition to the disease may be different in...
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
Article OPEN
Winkler, T.W.; Justice, A.E.; Graff, M.; Barata, L.; Feitosa, M.F.; Chu, S.; Czajkowski, J.; Esko, T.; Fall, T.; Kilpelainen, T.O.; Lu, Y.; Magi, R.; Mihailov, E.; Pers, T.H.; Rueger, S.; ...
(2015)

Project: NIH | RISK FACTORS FOR INCIDENT... (3R01AG011101-03S1), NIH | Data Mgmt &Analysis Core ... (5U01NS069208-02), NIH | CORONARY HEART DISEASE &S... (N01HC085080-018), NIH | CCSP - FIELD CENTER AND U... (N01HC055018-017), NIH | Exceptional aging: 12 yea... (5R01AG023629-03), NIH | Pharmacogenomics of CVD r... (3U01GM074518-05S1), NIH | Molecular Genetics of Sch... (5R01MH067257-03), NIH | UCLA Clinical and Transla... (5UL1TR000124-04), NIH | Genetic Influences on ADH... (1R01MH063706-01), NIH | TRIAL OF ASPIRIN AND VITA... (5R01CA047988-10), NIH | Genetics of cardiovascula... (5R01HL087679-02), NIH | AN NCRR CENTER FOR HIGH T... (5U54RR020278-04), NIH | Institute for Clinical an... (3UL1RR025005-03S2), NIH | Genetic Markers of CHD in... (5R01HL071981-04), NIH | SHORT-TERM STABILITY OF C... (1P30AG010161-01),...
Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these cha...
Interaction between prenatal growth and high-risk genotypes in the development of type 2 diabetes
Article English CLOSED
Pulizzi, N.; Lyssenko, V.; Jonsson, A.; Osmond, C.; Laakso, M.; Kajantie, E.; Barker, D. J.; Groop, L. C.; Eriksson, J. G.;
(2009)
Publisher: Springer Verlag

Project: EC | ENGAGE (201413)
Meta-analysis of telomere length in 19 713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect
Article, Other literature type English OPEN
Broer, Linda; Codd, Veryan; Nyholt, Dale R; Deelen, Joris; Mangino, Massimo; Willemsen, Gonneke; Albrecht, Eva; Amin, Najaf; Beekman, Marian; de Geus, Eco J C; Henders, Anjali; Nelson, Christopher P; Steves, Claire J; Wright, Margie J; de Craen, Anton J M; ...
(2013)
Publisher: NATURE PUBLISHING GROUP

Project: ARC | Elucidating the molecular... (FT0991022), EC | ENGAGE (201413), EC | IDEAL (259679), EC | GMI (230374), EC | ADDICTION (284167),WT, NWO | NCHA Subsidiebesluit 2008... (2300155116), NWO | tweeling onderzoek, met e... (2300133572), NWO | BBMRI-NL (2300154272), NHMRC | Validation and Replicatio... (496739)
Telomere length (TL) has been associated with aging and mortality, but individual differences are also influenced by genetic factors, with previous studies reporting heritability estimates ranging from 34 to 82%. Here we investigate the heritability, mode of inheritance...
A Genome-Wide Association Study Identifies Five Loci Influencing Facial Morphology in Europeans
Article English OPEN
Liu, Fan; Lijn, Fedde; Schurmann, Claudia; Zhu, Gu; Chakravarty, M Mallar; Hysi, Pirro; Wollstein, Andreas; Lao Grueso, Oscar; Bruijne, Marleen; Ikram, Arfan; Lugt, Aad; Rivadeneira Ramirez, Fernando; Uitterlinden, André; Hofman, Albert; Niessen, Wiro; ...
(2012)

Project: EC | GEFOS (201865), NHMRC | Twin and family studies o... (930223), NHMRC | Unravelling genetic influ... (496682), NHMRC | The Queensland Institute ... (983002), NHMRC | Genetics of melanoma risk... (389875), NHMRC | Genome-wide combined link... (389891), NHMRC | Importance of inherited f... (961061), NHMRC | Twin and family studies o... (900536), NHMRC | Mole development in pubes... (950998), NHMRC | Genetics of melanoma risk... (241944), NHMRC | Towards an etiological un... (613608), NHMRC | Investigating the role of... (552485), ARC | Quantitative and Molecula... (DP0212016), ARC | Locating genes for elemen... (DP0343921), ARC | From genotype to phenotyp... (LP110100121),...
textabstractInter-individual variation in facial shape is one of the most noticeable phenotypes in humans, and it is clearly under genetic regulation; however, almost nothing is known about the genetic basis of normal human facial morphology. We therefore conducted a ge...
Genome of the Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels
Article English OPEN
van Leeuwen, Elisabeth M.; Karssen, Lennart C.; Deelen, Joris; Isaacs, Aaron; Medina-Gomez, Carolina; Mbarek, Hamdi; Kanterakis, Alexandros; Trompet, Stella; Postmus, Iris; Verweij, Niek; van Enckevort, David J.; Huffman, Jennifer E.; White, Charles C.; Feitosa, Mary F.; Bartz, Traci M.; ...
(2015)
Publisher: Nature Pub. Group

Project: EC | ENGAGE (201413), EC | ADDICTION (284167), EC | GMI (230374), EC | PHASE (223004), NIH | Integration of Genomics &... (5RC2MH089951-02), NIH | Collaborative Study of Ge... (5R01HD042157-03), NIH | SUBCLINICAL CARDIOVASCULA... (N01HC095169-004), NIH | NIMH Center for Collabora... (3U24MH068457-07S2), NIH | Prospective meta-analyses... (1R01HL103612-01A1), NIH | Genomics of Developmental... (5RC2MH089995-02), NIH | CORONARY HEART DISEASE &S... (N01HC085083-021), NIH | MESA Family Study (5R01HL071259-03), NIH | Multi-Ethnic Study of Ath... (3R01HL071205-04S1), NIH | MESA Family Study (3R01HL071251-01A1S1), NIH | FHS-SCAN Genome Wide Asso... (3R01HL087700-02S1),...
<p>Variants associated with blood lipid levels may be population-specific. To identify low-frequency variants associated with this phenotype, population-specific reference panels may be used. Here we impute nine large Dutch biobanks (similar to 35,000 samples) with the ...
Pathway Analysis of GWAS Provides New Insights into Genetic Susceptibility to 3 Inflammatory Diseases
Article English OPEN
Hariklia Eleftherohorinou; Victoria Wright; Clive Hoggart; Anna-Liisa Hartikainen; Marjo-Riitta Jarvelin; David Balding; Lachlan Coin; Michael Levin;
(2009)
Publisher: PUBLIC LIBRARY SCIENCE

Project: AKA | GENETIC REGULATION OF THE... (120315), EC | ENGAGE (201413), AKA | Well-being and health: Re... (104781), NIH | Genetics of cardiovascula... (5R01HL087679-02), WT | The genetics of weight, B... (076113), NIH | Whole Genome Assoc. Analy... (1RL1MH083268-01)
Although the introduction of genome-wide association studies (GWAS) have greatly increased the number of genes associated with common diseases, only a small proportion of the predicted genetic contribution has so far been elucidated. Studying the cumulative variation of...
Pancreatic islet enhancer clusters enriched in type 2 diabetes risk–associated variants
Article English OPEN
Pasquali, Lorenzo; Gaulton, Kyle J; Rodríguez-Seguí, Santiago A; Mularoni, Loris; Miguel-Escalada, Irene; Akerman, Ildem; Tena, Juan J; Morán, Ignasi; Gómez-Marín, Carlos; van de Bunt, Martijn; Ponsa-Cobas, Joan; Castro, Natalia; Nammo, Takao; Cebola, Inês; García-Hurtado, Javier; ...
(2014)
Publisher: Nature Publishing Group

Project: EC | ENGAGE (201413), WT | Bridging the gap from typ... (095101), WT | Next-Generation Disease A... (090367), WT | Understanding regulatory ... (101033), WT | Understanding the genetic... (090532), WT | Characterising causal all... (098381)
Type 2 diabetes affects over 300 million people, causing severe complications and premature death, yet the underlying molecular mechanisms are largely unknown. Pancreatic islet dysfunction is central in type 2 diabetes pathogenesis, and understanding islet genome regula...
Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children.
Article English OPEN
Kilpeläinen, TO; Qi, L; Brage, S; Sharp, SJ; Sonestedt, E; Demerath, E; Ahmad, T; Mora, S; Kaakinen, M; Sandholt, CH; Holzapfel, C; Autenrieth, CS; Hyppönen, E; Cauchi, S; He, M; ...
(2011)
Publisher: Public Library of Science

Project: EC | ENGAGE (201413)
There are 116 authors. Only a few of them have been given author entries. Background: The FTO gene harbors the strongest known susceptibility locus for obesity. While many individual studies have suggested that physical activity (PA) may attenuate the effect of FT...

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