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  • Funder (1)
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82,114 publications, page 3 of 8,212
  • Preprint English OPEN
    Landrein, Benoit; Formosa-Jordan, Pau; Malivert, Alice; Schuster, Christoph; Melnyk, Charles W.; Yang, Weibing; Turnbull, Colin; Meyerowitz, Elliot M.; Locke, James C.W.; Jönsson, Henrik;
    (2017)
    Publisher: Cold Spring Harbor Laboratory
    The shoot apical meristem (SAM) is responsible for the generation of all of the aerial parts of plants 1 . Given its critical role, dynamical changes in SAM activity should play a central role in the adaptation of plant architecture to the environment 2 . Using quantita...
  • Preprint English OPEN
    Ziebell, Frederik; Dehler, Sascha; Martin-Villalba, Ana; Anna, Marciniak-Czochra;
    (2017)
    Publisher: Cold Spring Harbor Laboratory
    In the adult hippocampus, neural stem cells (NSCs) continuously produce new neurons that integrate into the neuronal network to modulate learning and memory. The amount and quality of newly generated neurons decline with age, which can be counteracted by increasing intr...
  • Preprint English OPEN
    Spagnolli, Giovanni; Massignan, Tania; Astolfi, Andrea; Biggi, Silvia; Brunelli, Paolo; Libergoli, Michela; Ianeselli, Alan; Orioli, Simone; Boldrini, Alberto; Terruzzi, Luca; Maietta, Giulia; Rigoli, Marta; Lorenzo, Nuria Lopez; Fernandez, Leticia C.; Tosatto, Laura; ...
    (2020)
    Publisher: Cold Spring Harbor Laboratory
    ABSTRACT Recent computational advancements in the simulation of biochemical processes allow investigating the mechanisms involved in protein regulation with realistic physics-based models, at an atomistic level of resolution. Using these techniques to study the negativ...
  • Preprint English OPEN
    Malik, Ahmed M.; Miguez, Roberto A.; Li, Xingli; Ho, Ye-Shih; Feldman, Eva L.; Barmada, Sami J.;
    (2018)
    Publisher: Cold Spring Harbor Laboratory
    ABSTRACT Abnormalities in nucleic acid processing are associated with the development of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Mutations in Matrin 3 ( MATR3 ), a poorly understood DNA- and RNA-binding protein, cause familial ALS/FTD, ...
  • Preprint English OPEN
    Kandul, Nikolay P.; Liu, Junru; Buchman, Anna; Gantz, Valentino M.; Bier, Ethan; Akbari, Omar S.;
    (2019)
    Publisher: Cold Spring Harbor Laboratory
    Abstract Homing based gene drives (HGD) possess the potential to spread linked cargo genes into natural populations and are poised to revolutionize population control of animals. Given that host-encoded genes have been identified that are important for pathogen transmi...
  • Preprint English OPEN
    Siemons, M.; Hulleman, C. N.; Thorsen, R. Ø.; Smith, C. S.; Stallinga, S.;
    (2018)
    Publisher: Cold Spring Harbor Laboratory
    Abstract Point spread function (PSF) engineering is used in single emitter localization to measure the emitter position in 3D and possibly other parameters such as the emission color or dipole orientation as well. Advanced PSF models such as spline fits to experimental...
  • Preprint English OPEN
    Zhu, Qin; Gao, Peng; Tober, Joanna; Bennett, Laura; Chen, Changya; Uzun, Yasin; Li, Yan; Mumau, Melanie; Yu, Wenbao; He, Bing; Speck, Nancy A.; Tan, Kai;
    (2019)
    Publisher: Cold Spring Harbor Laboratory
    Summary Hematopoietic stem and progenitor cells (HSPCs) differentiate from hemogenic endothelial (HE) cells through an endothelial to hematopoietic cell transition (EHT). Newly formed HSPCs accumulate in intra-arterial clusters (IACs) before colonizing the fetal liver....
  • Preprint English OPEN
    Hackett, Sean R.; Baltz, Edward A.; Coram, Marc; Wranik, Bernd J.; Kim, Griffin; Baker, Adam; Fan, Minjie; Hendrickson, David G.; Berndl, Marc; McIsaac, R. Scott;
    (2019)
    Publisher: Cold Spring Harbor Laboratory
    Abstract We present an approach for inferring genome-wide regulatory causality and demonstrate its application on a yeast dataset constructed by independently inducing hundreds of transcription factors and measuring timecourses of the resulting gene expression response...
  • Preprint English OPEN
    Fruzangohar, Mario; Ebrahimie, Esmaeil; Adelson, David L;
    (2014)
    Publisher: Cold Spring Harbor Laboratory
    Gene Ontology (GO) classification of statistically significant over/under expressed genes is a commonly used to interpret transcriptomics data in functional genomic analysis. In this approach, all significant genes contribute equally to the final GO classification regar...
  • Preprint English OPEN
    Toth, Reka; Schiffmann, Heiko; Hube-Magg, Claudia; Büscheck, Franziska; Höflmayer, Doris; Weidemann, Sören; Lebok, Patrick; Fraune, Christoph; Minner, Sarah; Schlomm, Thorsten; Sauter, Guido; Plass, Christoph; Assenov, Yassen; Simon, Ronald; Meiners, Jan; ...
    (2019)
    Publisher: Cold Spring Harbor Laboratory
    Abstract The clinical course of prostate cancer (PCa) is highly variable, demanding an individualized approach to therapy and robust prognostic markers for treatment decisions. We present a random forest-based classification model to predict aggressive behaviour of PCa...
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