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82,114 publications, page 2 of 8,212
  • Preprint English OPEN
    Yu, Haopeng; Meng, Wenjing; Mao, Yuanhui; Zhang, Yi; Sun, Qing; Tao, Shiheng;
    (2018)
    Publisher: Cold Spring Harbor Laboratory
    The structure of mRNA in vivo is influenced by various factors involved in the translation process, resulting in significant differentiation of mRNA structure from that in vitro . Because multiple factors cause the differentiation of in vivo and in vitro mRNA str...
  • Preprint English OPEN
    Wei, Fu-Jin; Ueno, Saneyoshi; Ujino-Ihara, Tokuko; Saito, Maki; Tsumura, Yoshihiko; Higuchi, Yuumi; Hirayama, Satoko; Iwai, Junji; Hakamata, Tetsuji; Moriguchi, Yoshinari;
    (2020)
    Publisher: Cold Spring Harbor Laboratory
    Abstract Sugi ( Cryptomeria japonica D. Don) is an important conifer used for afforestation in Japan. The field of functional genomics is rapidly developing. The genomics of this gymnosperm species is currently being studied. Although its genomic size is 11 Gbps, it i...
  • Preprint English OPEN
    Weikop, Pia; Jensen, Kathrine L.; Thomsen, Morgane;
    (2020)
    Publisher: Cold Spring Harbor Laboratory
    ABSTRACT Cocaine addiction is a chronic illness characterized by maladaptive drug-induced neuroplastic changes that confer lasting vulnerability to relapse. Over several weeks we observed the effects of the M 1 receptor-selective agonist VU0364572 in adult male rats t...
  • Preprint English OPEN
    Rajbhandari, AK; Octeau, JC; Gonzalez, S; Pennington, ZT; Trott, J; Chavez, J; Ngyuen, E; Keces, N; Hong, WZ; Neve, RL; Waschek, J; Khakh, BS; Fanselow, MS;
    (2020)
    Publisher: Cold Spring Harbor Laboratory
    Abstract Trauma can cause dysfunctional fear regulation leading some to develop disorders like post-traumatic stress disorder (PTSD). The amygdala regulates fear, and, PACAP and PAC1 receptors are linked to PTSD symptom severity at genetic/epigenetic levels, with a str...
  • Preprint English OPEN
    Bally, Alexander P. R.; Neeld, Dennis K.; Lu, Peiyuan; Majumder, Parimal; Tang, Yan; Barwick, Benjamin G.; Wang, Qing; Boss, Jeremy M.;
    (2019)
    Publisher: Cold Spring Harbor Laboratory
    Abstract During prolonged exposure to antigens, such as chronic viral infections, sustained T cell receptor (TCR) signaling can result in T cell exhaustion mediated in part by expression of Programmed cell death-1 (PD-1) encoded by the Pdcd1 gene. Here, dynamic chang...
  • Preprint English OPEN
    Vogg, Matthias C.; Beccari, Leonardo; Iglesias Ollé, Laura; Rampon, Christine; Vriz, Sophie; Perruchoud, Chrystelle; Wenger, Yvan; Galliot, Brigitte;
    (2018)
    Publisher: Cold Spring Harbor Laboratory
    Abstract The Hydra polyp regenerates its head by transforming the gastric tissue below the wound into a head organizer made of two antagonistic cross-reacting components. The activator, previously characterized as Wnt3 , drives apical differentiation by acting local...
  • Preprint English OPEN
    Mandal, Punam Kumari; Wagle, Rajendra Raj; Thakur, Ajoy Kumar; Uranw, Surendra;
    (2019)
    Publisher: Cold Spring Harbor Laboratory
    Abstract Visceral leishmaniasis is a major public health concern in Nepal. During the last few years, several KA outbreaks have been reported from Tarai region including Morang district. A case control study was conducted to assess the risk factors associated with VL i...
  • Preprint English OPEN
    Reichhardt, Martin P.; Johnson, Steven; Tang, Terence; Morgan, Thomas; Tebeka, Nchimunya; Popitsch, Niko; Deme, Justin C.; Jore, Matthijs M.; Lea, Susan M.;
    (2019)
    Publisher: Cold Spring Harbor Laboratory
    Abstract The complement system is a crucial part of innate immune defences against invading pathogens. The blood-meal of the tick Rhipicephalus pulchellus lasts for days, and the tick must therefore rely on inhibitors to counter complement activation. We have identif...
  • Preprint English OPEN
    Woo, Xing Yi; Giordano, Jessica; Srivastava, Anuj; Zhao, Zi-Ming; Lloyd, Michael W.; de Bruijn, Roebi; Suh, Yun-Suhk; Patidar, Rajesh; Chen, Li; Scherer, Sandra; Bailey, Matthew; Yang, Chieh-Hsiang; Cortes-Sanchez, Emilio; Xi, Yuanxin; Wang, Jing; ...
    (2019)
    Publisher: Cold Spring Harbor Laboratory
    ABSTRACT Patient-derived xenografts (PDXs) are resected human tumors engrafted into mice for preclinical studies and therapeutic testing. It has been proposed that the mouse host affects tumor evolution during PDX engraftment and propagation, impacting the accuracy of ...
  • Preprint English OPEN
    Metlagel, Zoltan; Krey, Jocelyn F; Song, Junha; Swift, Mark F; Tivol, William J; Dumont, Rachel A; Thai, Jasmine; Chang, Alex; Seifikar, Helia; Volkmann, Niels; Hanein, Dorit; Barr-Gillespie, Peter G; Auer, Manfred;
    (2018)
    Publisher: Cold Spring Harbor Laboratory
    High-resolution imaging of hair-cell stereocilia of the inner ear has contributed substantially to our understanding of auditory and vestibular function. To provide three-dimensional views of the structure of stereocilia cytoskeleton and membranes, we developed a method...
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