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81,226 publications, page 1 of 8,123
  • Preprint English OPEN
    Wong, Ting; Hall, Jesse; Boehm, Dylan; Barbier, Mariette; Heath Damron, F.;
    (2017)
    Publisher: Cold Spring Harbor Laboratory
    Abstract Bordetella pertussis is an obligate human respiratory pathogen that causes the disease whooping cough. A whole cell vaccine (DTP) was developed in the 1940s and was subsequently replaced in the 1990s with a protein-based subunit acellular vaccine (DTaP; tdap...
  • Preprint English OPEN
    Tiger Li, Zheng-Rong; Zarnitsyna, Veronika I.; Lowen, Anice C.; Weissman, Daniel; Koelle, Katia; Kohlmeier, Jacob E.; Antia, Rustom;
    (2018)
    Publisher: Cold Spring Harbor Laboratory
    Abstract The high-degree conservation of CD8 T cell epitopes of influenza A virus (IAV) may allow T cell-inducing vaccines effective across different strains and subtypes. This conservation is not fully explained by functional constraint, since additional mutation(s) c...
  • Preprint English OPEN
    Zhu, Zhenglin; Meng, Geng;
    (2019)
    Publisher: Cold Spring Harbor Laboratory
    Abstract The recent outbreaks of African swine fever (ASF) in China and Europe have threatened the swine industry globally. To control the transmission of the African swine fever virus (ASFV), we developed ASFVdb, the African swine fever virus database, an online data ...
  • Preprint English OPEN
    McCleery, W. T.; Veldhuis, J.; Brodland, G. W.; Bennett, M. E.; Hutson, M. S.;
    (2018)
    Publisher: Cold Spring Harbor Laboratory
    ABSTRACT During Drosophila embryogenesis, the germband first extends to curl around the posterior end of the embryo, and then retracts back; however, retraction is not simply the reversal of extension. At a tissue level, extension is coincident with ventral furrow fo...
  • Preprint English OPEN
    Bowler, Diana E.; Kvasnes, Mikkel A. J.; Pedersen, Hans C.; Sandercock, Brett K.; Nilsen, Erlend B.;
    (2020)
    Publisher: Cold Spring Harbor Laboratory
    Abstract According to classic theory, species interactions are less important than climatic variation for species’ population dynamics and distributions in climatically harsh regions compared with more climatically benign regions. In boreal ecosystems, the cyclic dynam...
  • Preprint English OPEN
    Hanson, Laura; Sethuramanujam, Santhosh; deRosenroll, Geoff; Awatramani, Gautam B.;
    (2018)
    Publisher: Cold Spring Harbor Laboratory
    S ummary In the mammalian retina, asymmetric inhibitory signals arising from the direction-selective dendrites of GABAergic/cholinergic starburst amacrine cells are thought to be crucial for originating direction selectivity. Contrary to this notion, however, we found...
  • Preprint English OPEN
    Lassi, Glenda; Tan, Vanessa; Mahedy, Liam; Oliveira, Ana Sofia F.; Dyer, Maddy L.; Drax, Katie; Dawkins, Lynne; Rennard, Stephen; Matcham, James; Timpson, Nicholas J.; Eisen, Tim; Munafò, Marcus R.;
    (2019)
    Publisher: Cold Spring Harbor Laboratory
    Abstract Genome-wide association studies have identified associations between variation at rs16969968/rs1051730 in the CHRNA5–A3–B4 gene cluster and smoking related outcomes. Experiments in rodents have described the nicotinic acetylcholine receptors (nAChRs) subunit...
  • Preprint English OPEN
    Vanwalleghem, Gilles; Schuster, Kevin; Taylor, Michael A.; Favre-Bulle, Itia A.; Scott, Ethan K.;
    (2020)
    Publisher: Cold Spring Harbor Laboratory
    Abstract Information about water flow, detected by lateral line organs, is critical to the behavior and survival of fish and amphibians. While certain specific aspects of water flow processing have been revealed through electrophysiology, we lack a comprehensive descri...
  • Preprint English OPEN
    Saitou, M.; Satta, Y.; Gokcumen, O.;
    (2018)
    Publisher: Cold Spring Harbor Laboratory
    ABSTRACT The deletion of the metabolizing Glutathione S-transferase Mu 1 ( GSTM1 ) gene was previously associated with multiple cancers, metabolic and autoimmune disorders, as well as drug response. It is unusually common, with allele frequency reaching up to 75% in so...
  • Preprint English OPEN
    Fulco, Charles P.; Nasser, Joseph; Jones, Thouis R.; Munson, Glen; Bergman, Drew T.; Subramanian, Vidya; Grossman, Sharon R.; Anyoha, Rockwell; Patwardhan, Tejal A.; Nguyen, Tung H.; Kane, Michael; Doughty, Benjamin; Perez, Elizabeth M.; Durand, Neva C.; Stamenova, Elena K.; ...
    (2019)
    Publisher: Cold Spring Harbor Laboratory
    Abstract Mammalian genomes harbor millions of noncoding elements called enhancers that quantitatively regulate gene expression, but it remains unclear which enhancers regulate which genes. Here we describe an experimental approach, based on CRISPR interference, RNA FIS...
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