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7,441 Projects, page 1 of 745

  • 2021-2021
  • 2015

10
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  • Funder: NWO Project Code: 29587
  • Funder: UKRI Project Code: ES/N009614/1
    Funder Contribution: 7,586,770 GBP
    Partners: Lancaster University, TITAN NW Regional Organized Crime Unit

    The social sciences have made important contributions to our understanding of security threats and the skills and technologies that can mitigate them. However, these contributions have yet to achieve their full impact on practice for two reasons. First, they draw on a diverse set of disciplinary perspectives and epistemologies, and are rarely understood holistically. As a result, there remains much to be learned from their systematic integration. Second, many contributions have been made without a full appreciation of the challenges and constraints faced by the security and intelligence agencies. There is thus a need to facilitate researcher-stakeholder exchanges that promote understanding and empower researchers to make impactful contributions. The Centre for Research and Evidence on Security Threats (CREST) will deliver a world-class, interdisciplinary portfolio of activity that maximises the value of social science to countering threats to national security. CREST brings together leading researchers from seven disciplines, government and industry stakeholders, and communication specialists to coordinate an international network of excellence that delivers five Agendas. These Agendas seek to enhance the skills and understanding of agency practitioners, develop capacity and capability in academia, build mutual understanding between stakeholders and academia, and maximise the impact of social science research and analysis. The KNOWLEDGE SYNTHESIS AGENDA will deliver state-of-the-art reviews that address key stakeholder questions by mapping out the evidence base and by providing policy and 'best practice' recommendations. Each participating Institution will lead one of five programmes: Actors and narratives; Ideas, beliefs and values in social context; Understanding and countering online behaviour; Eliciting information; and, Protective security and risk assessment. The ORIGINAL RESEARCH AGENDA will build on Knowledge Synthesis by generating theoretically motivated, high-quality new research that either addresses gaps identified in the existing literature, or demonstrates the operational relevance of existing knowledge to stakeholder contexts. As part of the Knowledge Synthesis and Original Research Agendas, £1.89m of CREST's funds will support COMMISSIONED ACTIVITIES, including synthetic reviews, workshops, toolkit development, and research projects. Funds will be allocated via a transparent and competitive process that delivers scientific excellence, stakeholder relevance, and value for money. With support from an Advisory Board and Programme Ambassadors, the COMMUNICATION AGENDA will use a range of innovative media (e.g. video briefings, interactive toolkits) to ensure that outputs from the Knowledge Synthesis and Original Research Agendas are communicated effectively to a range of audiences. Target audiences include intelligence officers to improve operational effectiveness, policy makers to support evidence-based policy, industry to help generate sector growth, and the public at large to increase awareness of the challenges faced within the UK. The NETWORKING AGENDA will deliver a range of events (e.g. workshops, 'hackathons') that support interaction between research and stakeholder communities at both strategic and grass-roots levels. These events will draw together a community of contributors leading to new and innovative contributions to theory and practice. The CAPACITY-BUILDING AGENDA will ensure the long-term sustainability of CREST while also delivering a step-change in capability in three areas: (1) the next generation of researchers and educators within the discipline (e.g. through PhD training); (2) the formal professional development of officers in the intelligence agencies (e.g. through online training, secondments); and, (3) the economic effectiveness of industry (e.g. SMEs) through knowledge exchange The funding for this grant comes in part from the UK security and intelligence agencies.

  • Open Access mandate for Publications
    Funder: EC Project Code: 639485
    Overall Budget: 1,499,740 EURFunder Contribution: 1,499,740 EUR
    Partners: Imperial

    Randomness pervades life and biological systems are continuously subject to variation. This variation may be stochastic, due to random fluctuations in the concentration of critical molecules, genetic, due to mutation accumulation, or environmental, because of changes in the environment over time. It is therefore remarkable how biological systems manage to operate with so much precision. The property of a system to produce an invariant output in the presence of considerable noise is called robustness. Development itself is highly robust to noise and this is instrumental for the successful transformation of a fertilised egg into a multi-cellular individual. Developmental robustness ensures the stability of phenotypic traits, including correct cell numbers in a given tissue. While research on developmental robustness has seen a surge over the last 15 years, most studies have remained theoretical, and we still lack appropriate experimental systems to elucidate the mechanisms via which robust outputs are achieved. We propose here to follow a system-wide, integrative approach to study the mechanisms, evolution and consequences of developmental robustness in a multi-cellular model organism. To this end, C. elegans is a very attractive system because developmental patterning is highly stereotypical and animals are isogenic, thereby allowing precise control of the genetic background. Focusing on a new experimental model, the epithelial seam cell number variation, and using comprehensive molecular developmental genetics, genomics and imaging we will derive principles about the contribution of genes to stabilisation of developmental outcomes and will develop a developmental framework for phenotypic buffering. Understanding the fundamental mechanisms underlying developmental robustness is highly relevant to biomedical sciences, as many diseases can be understood in the context of debuffering of normal physiological states.

  • Funder: NIH Project Code: 5R01AA023522-05
    Funder Contribution: 658,994 USD
    Partners: Brown University
  • Funder: NIH Project Code: 5R01NS092548-05
    Funder Contribution: 342,888 USD
    Partners: University of Virginia
  • Funder: NIH Project Code: 5R01HD081868-05
    Funder Contribution: 510,054 USD
    Partners: BUTLER HOSPITAL (PROVIDENCE, RI)
  • Funder: NIH Project Code: 5R01DC014281-05
    Funder Contribution: 499,663 USD
    Partners: University of Rome
  • Funder: NIH Project Code: 5R35CA197459-05
    Funder Contribution: 877,757 USD
    Partners: HSPH
  • Funder: NIH Project Code: 2UL1TR001430-05A1
    Funder Contribution: 6,457,641 USD
    Partners: BOSTON UNIVERSITY MEDICAL CAMPUS
  • Funder: UKRI Project Code: EP/N509103/1
    Funder Contribution: 1,957,400 GBP
    Partners: University of Cambridge

    Doctoral Training Partnerships: a range of postgraduate training is funded by the Research Councils. For information on current funding routes, see the common terminology at www.rcuk.ac.uk/StudentshipTerminology. Training grants may be to one organisation or to a consortia of research organisations. This portal will show the lead organisation only.

search
7,441 Projects, page 1 of 745
  • Funder: NWO Project Code: 29587
  • Funder: UKRI Project Code: ES/N009614/1
    Funder Contribution: 7,586,770 GBP
    Partners: Lancaster University, TITAN NW Regional Organized Crime Unit

    The social sciences have made important contributions to our understanding of security threats and the skills and technologies that can mitigate them. However, these contributions have yet to achieve their full impact on practice for two reasons. First, they draw on a diverse set of disciplinary perspectives and epistemologies, and are rarely understood holistically. As a result, there remains much to be learned from their systematic integration. Second, many contributions have been made without a full appreciation of the challenges and constraints faced by the security and intelligence agencies. There is thus a need to facilitate researcher-stakeholder exchanges that promote understanding and empower researchers to make impactful contributions. The Centre for Research and Evidence on Security Threats (CREST) will deliver a world-class, interdisciplinary portfolio of activity that maximises the value of social science to countering threats to national security. CREST brings together leading researchers from seven disciplines, government and industry stakeholders, and communication specialists to coordinate an international network of excellence that delivers five Agendas. These Agendas seek to enhance the skills and understanding of agency practitioners, develop capacity and capability in academia, build mutual understanding between stakeholders and academia, and maximise the impact of social science research and analysis. The KNOWLEDGE SYNTHESIS AGENDA will deliver state-of-the-art reviews that address key stakeholder questions by mapping out the evidence base and by providing policy and 'best practice' recommendations. Each participating Institution will lead one of five programmes: Actors and narratives; Ideas, beliefs and values in social context; Understanding and countering online behaviour; Eliciting information; and, Protective security and risk assessment. The ORIGINAL RESEARCH AGENDA will build on Knowledge Synthesis by generating theoretically motivated, high-quality new research that either addresses gaps identified in the existing literature, or demonstrates the operational relevance of existing knowledge to stakeholder contexts. As part of the Knowledge Synthesis and Original Research Agendas, £1.89m of CREST's funds will support COMMISSIONED ACTIVITIES, including synthetic reviews, workshops, toolkit development, and research projects. Funds will be allocated via a transparent and competitive process that delivers scientific excellence, stakeholder relevance, and value for money. With support from an Advisory Board and Programme Ambassadors, the COMMUNICATION AGENDA will use a range of innovative media (e.g. video briefings, interactive toolkits) to ensure that outputs from the Knowledge Synthesis and Original Research Agendas are communicated effectively to a range of audiences. Target audiences include intelligence officers to improve operational effectiveness, policy makers to support evidence-based policy, industry to help generate sector growth, and the public at large to increase awareness of the challenges faced within the UK. The NETWORKING AGENDA will deliver a range of events (e.g. workshops, 'hackathons') that support interaction between research and stakeholder communities at both strategic and grass-roots levels. These events will draw together a community of contributors leading to new and innovative contributions to theory and practice. The CAPACITY-BUILDING AGENDA will ensure the long-term sustainability of CREST while also delivering a step-change in capability in three areas: (1) the next generation of researchers and educators within the discipline (e.g. through PhD training); (2) the formal professional development of officers in the intelligence agencies (e.g. through online training, secondments); and, (3) the economic effectiveness of industry (e.g. SMEs) through knowledge exchange The funding for this grant comes in part from the UK security and intelligence agencies.

  • Open Access mandate for Publications
    Funder: EC Project Code: 639485
    Overall Budget: 1,499,740 EURFunder Contribution: 1,499,740 EUR
    Partners: Imperial

    Randomness pervades life and biological systems are continuously subject to variation. This variation may be stochastic, due to random fluctuations in the concentration of critical molecules, genetic, due to mutation accumulation, or environmental, because of changes in the environment over time. It is therefore remarkable how biological systems manage to operate with so much precision. The property of a system to produce an invariant output in the presence of considerable noise is called robustness. Development itself is highly robust to noise and this is instrumental for the successful transformation of a fertilised egg into a multi-cellular individual. Developmental robustness ensures the stability of phenotypic traits, including correct cell numbers in a given tissue. While research on developmental robustness has seen a surge over the last 15 years, most studies have remained theoretical, and we still lack appropriate experimental systems to elucidate the mechanisms via which robust outputs are achieved. We propose here to follow a system-wide, integrative approach to study the mechanisms, evolution and consequences of developmental robustness in a multi-cellular model organism. To this end, C. elegans is a very attractive system because developmental patterning is highly stereotypical and animals are isogenic, thereby allowing precise control of the genetic background. Focusing on a new experimental model, the epithelial seam cell number variation, and using comprehensive molecular developmental genetics, genomics and imaging we will derive principles about the contribution of genes to stabilisation of developmental outcomes and will develop a developmental framework for phenotypic buffering. Understanding the fundamental mechanisms underlying developmental robustness is highly relevant to biomedical sciences, as many diseases can be understood in the context of debuffering of normal physiological states.

  • Funder: NIH Project Code: 5R01AA023522-05
    Funder Contribution: 658,994 USD
    Partners: Brown University
  • Funder: NIH Project Code: 5R01NS092548-05
    Funder Contribution: 342,888 USD
    Partners: University of Virginia
  • Funder: NIH Project Code: 5R01HD081868-05
    Funder Contribution: 510,054 USD
    Partners: BUTLER HOSPITAL (PROVIDENCE, RI)
  • Funder: NIH Project Code: 5R01DC014281-05
    Funder Contribution: 499,663 USD
    Partners: University of Rome
  • Funder: NIH Project Code: 5R35CA197459-05
    Funder Contribution: 877,757 USD
    Partners: HSPH
  • Funder: NIH Project Code: 2UL1TR001430-05A1
    Funder Contribution: 6,457,641 USD
    Partners: BOSTON UNIVERSITY MEDICAL CAMPUS
  • Funder: UKRI Project Code: EP/N509103/1
    Funder Contribution: 1,957,400 GBP
    Partners: University of Cambridge

    Doctoral Training Partnerships: a range of postgraduate training is funded by the Research Councils. For information on current funding routes, see the common terminology at www.rcuk.ac.uk/StudentshipTerminology. Training grants may be to one organisation or to a consortia of research organisations. This portal will show the lead organisation only.

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