Bacteria protect themselves against bacteriophage (phage) infection using defensive systems, with phages co-evolving counter-resistant strategies. Several anti-phage systems have been identified and their modes of action determined. Additionally, nine novel systems were...

Element seeks Wellcome funding to cover Deep Learning experimentation and core feature development to ensure the infant biometric solution is fit-for-use in low-resource healthcare contexts. This includes pioneering innovations in accuracy by combining modality recognit...

Understanding the neural circuit basis of behaviour is one of the great challenges in biology. Yet no single laboratory can study the many brain regions, connections, and cell types working together o coordinate decision-making. There is thus a disparity between the cap...

Cells must communicate with their neighbours, send, and receive various information as they build and regenerate tissues. This communication is often not well understood, for example during the very first steps of cancer growth. Pre-neoplastic cells (PNCs) (the first ce...

Magnetic resonance imaging (MRI) it is a powerful technique which allows brain tissue to be explored indirectly. Despite more than 40 years of innovation, the standard clinical MRI protocol remains largely unchanged: a set of 3 images influenced by ‘relaxation’ phenomen...

Current research suggests that homo sapiens originated in numerous subdivided populations, opposing the traditional view that we evolved from a single region/population. Existing methods for detecting the size of ancestral populations are limited by their assumption tha...

Tissue morphogenesis is associated with dramatic changes in cell morphology. Whilst these cell shape changes may define final tissue form, how they impact and/or direct other key morphogenetic processes remains unclear. I aim to redefine our understanding of the role of...

Ebola virus disease has been declared a Public Health Emergency of International Concern in Democratic Republic of the Congo. In the short term, our consortium plans to optimise, manufacture, and validate a novel Ebola rapid diagnostic test (RDT) for deployment at the p...

The process of endosomal sorting, where internalised transmembrane proteins (cargoes) are sorted for lysosomal degradation or recycled back to the cell surface, maintains and regulates the cell surface proteome. Thus, endosomal sorting regulates numerous cellular proces...

My research is about what influences people in Ghana to use cancer services. Cancer is an increasing problem in Ghana due to changes to lifestyle and population age. Many things influence cancer services use including, disease beliefs, stigma, healthcare trust, and cost...