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604 projects, page 1 of 61
  • project . 2020 - 2025
    Funder: WT Project Code: 219500
    Funder Contribution: 1,740,980 GBP
    Open Access mandate for Publications
    Partners: UNIVERSITY OF VICTORIA

    Tissue morphogenesis is associated with dramatic changes in cell morphology. Whilst these cell shape changes may define final tissue form, how they impact and/or direct other key morphogenetic processes remains unclear. I aim to redefine our understanding of the role of...

  • project . 2020 - 2028
    Funder: WT Project Code: 218510
    Funder Contribution: 5,488,460 GBP
    Open Access mandate for Publications
    Partners: University of Bristol

    Identifying disease-associated genes, mutations and perturbed expression is only the first stage towards understanding human disease and the development of therapeutics. In Bristol we aspire to understand gene function and the proteins they encode across spatial scales,...

  • project . 2020 - 2024
    Funder: WT Project Code: 219506
    Funder Contribution: 4,041,770 GBP
    Open Access mandate for Publications
    Partners: University of Cambridge

    Primary Immunodeficiency (PID) has a devastating impact on the lives of patients and their families, and management is aided by genetic diagnosis. 80% of PID patients have no overt family history, and thus have been intractable to gene discovery. Our recent pilot study ...

  • project . 2020 - 2024
    Funder: WT Project Code: 220429
    Funder Contribution: 300,000 GBP
    Open Access mandate for Publications
    Partners: University College London

    Motivation: Interventions mobilising communities in collective action for their own health are some of the most effective known global health interventions. However, they do not always succeed and we cannot presently predict or explain why this happens. Aim: Taking as a...

  • project . 2020 - 2023
    Funder: WT Project Code: 222359
    Open Access mandate for Publications
    Partners: Wellcome / MRC Cambridge Stem Cell Institute

    Regenerative cardiovascular medicine is emerging as a novel therapeutic alternative to heart transplantation in patients suffering from chronic heart failure. This approach aims to restore cardiac functionality by exogenous transplantation of stem cell-derived cardiomyo...

  • project . 2020 - 2022
    Funder: WT Project Code: 218585
    Funder Contribution: 499,992 GBP
    Open Access mandate for Publications
    Partners: GlaxoSmithKline

    Tp identify the top-4 molecules by the end of the grant. From those, a preclinical candidate mAb that can be used as a single prophylactic agent to prevent liver stage P. falciparum malaria infection, with significant improvement upon the existing parental AB317, will b...

  • project . 2020 - 2023
    Funder: WT Project Code: 222316
    Open Access mandate for Publications
    Partners: University of Cambridge

    Pulmonary arterial hypertension (PAH) is a fatal disease in which the blood vessels of the lung thicken and narrow, causing an increase in blood pressure and eventually right heart failure. In order to develop new therapies for PAH the mechanisms underlying the progress...

  • project . 2020 - 2023
    Funder: WT Project Code: 222365
    Open Access mandate for Publications
    Partners: Wellcome / MRC Cambridge Stem Cell Institute

    Transcription factor (TF) networks are cardinally dysregulated in Acute Myeloid Leukaemia (AML), with many of these dysregulated TFs known to have developmental and homeostatic roles in normal haematopoiesis. I will focus on the E-twenty six (ETS) TF Pu.1 that is known ...

  • project . 2020 - 2024
    Funder: WT Project Code: 220480
    Funder Contribution: 300,000 GBP
    Open Access mandate for Publications
    Partners: UNIVERSITY OF CALIFORNIA SAN FRANCISCO

    The process of endosomal sorting, where internalised transmembrane proteins (cargoes) are sorted for lysosomal degradation or recycled back to the cell surface, maintains and regulates the cell surface proteome. Thus, endosomal sorting regulates numerous cellular proces...

  • project . 2020 - 2025
    Funder: WT Project Code: 215593
    Funder Contribution: 2,273,710 GBP
    Open Access mandate for Publications
    Partners: University College London

    Ribonucleoprotein complexes (RNPs) play key roles in RNA regulation. Many mRNAs, especially those localised to neuronal axons or dendrites, promote the condensation of RNPs into microscopically visible complexes, often referred to as ‘RNA granules’. Mutations in RNA-bin...

604 projects, page 1 of 61