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89 projects, page 1 of 9
  • project . 2021 - 2026
    Funder: WT Project Code: 221824
    Funder Contribution: 1,973,120 GBP
    Open Access mandate for Publications
    Partners: KINGS COLLEGE LONDON

    TDP-43 is a conserved RNA binding protein central to the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). TDP-43 normally autoregulates its expression by binding to the 3’UTR of its cognate transcript. We have linked disrupted TDP-4...

  • project . 2020 - 2026
    Funder: WT Project Code: FC001988
    Open Access mandate for Publications
    Partners: The Francis Crick Institute
  • project . 2021 - 2026
    Funder: WT Project Code: 221737
    Funder Contribution: 1,827,980 GBP
    Open Access mandate for Publications
    Partners: Edinburgh University

    The type I interferon (IFN) response is the major antiviral pathway in mammals but needs to be tightly regulated to ensure effective defence against viruses whilst avoiding the negative consequences of their overproduction, resulting in autoimmune and autoinflammatory d...

  • project . 2021 - 2026
    Funder: WT Project Code: 222101
    Funder Contribution: 1,194,430 GBP
    Open Access mandate for Publications
    Partners: Oxford University

    Entrapment neuropathies are the most common conditions causing nerve-related pain. Even though Physiotherapy is the recommended treatment, research suggests only modest benefits. A major road-block is the lack of adequate patient stratification. My fellowship will addre...

  • project . 2020 - 2026
    Funder: WT Project Code: FC011005
    Open Access mandate for Publications
    Partners: The Francis Crick Institute
  • project . 2021 - 2026
    Funder: WT Project Code: 221817
    Funder Contribution: 1,110,040 GBP
    Open Access mandate for Publications
    Partners: The Francis Crick Institute, UNIVERSITY OF VICTORIA

    Wnt and Hedgehog signalling regulate intestinal stem cell dynamics to ensure intestinal renewal, function and integrity is maintained. The activation of these two pathways involves crosstalk and communication between the mesenchymal and epithelial layers of the intestin...

  • project . 2020 - 2026
    Funder: WT Project Code: FC011103
    Open Access mandate for Publications
    Partners: The Francis Crick Institute
  • project . 2021 - 2026
    Funder: WT Project Code: 221794
    Funder Contribution: 2,336,910 GBP
    Open Access mandate for Publications
    Partners: Oxford University

    The overarching aim is to understand the neural mechanisms of learning, decision-making, and motivation in humans. We will examine how they emerge from distributed patterns of activity across networks of subcortical nuclei such as the basal forebrain and dorsal raphe nu...

  • project . 2021 - 2026
    Funder: WT Project Code: 221803
    Funder Contribution: 1,904,150 GBP
    Open Access mandate for Publications
    Partners: London School of Hygiene and Tropical Medicine

    Invasive pneumococcal disease causes over a million deaths per year worldwide, particularly in sub-Saharan Africa. Streptococcus pneumoniae strains vary considerably in virulence, but the reasons for this are unclear. Capsular serotype 1 strains are particularly invasiv...

  • project . 2021 - 2026
    Funder: WT Project Code: 221890
    Funder Contribution: 886,561 GBP
    Open Access mandate for Publications
    Partners: Edinburgh University

    Ageing-related cognitive decline carries a huge personal, societal, and financial cost. Understanding its underlying mechanisms with a view to ameliorating age-related cognitive decline is a huge challenge. It is essential to identify biomarkers of cognitive ageing and ...

89 projects, page 1 of 9