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  • Open Access English
    Authors: 
    Laura Pintado-Berninches; Beatriz Fernández-Varas; Carlos Benitez-Buelga; Cristina Manguan-García; Almudena Serrano-Benitez; Laura Iarriccio; Jaime Carrillo; Guillermo Guenechea; Susana P. Egusquiaguirre; J.L. Pedraz; +6 more
    Publisher: Nature Publishing Group UK
    Country: Spain

    Ataxia telangiectasia (AT) is a genetic disease caused by mutations in the ATM gene but the mechanisms underlying AT are not completely understood. Key functions of the ATM protein are to sense and regulate cellular redox status and to transduce DNA double-strand break ...

  • Open Access English
    Authors: 
    Alejandro Álvarez-Quilón; José Terrón-Bautista; Irene Delgado-Sainz; Almudena Serrano-Benitez; Rocío Romero-Granados; Pedro Manuel Martínez-García; Silvia Jimeno-González; Cristina Bernal-Lozano; Cristina Quintero; Lourdes García-Quintanilla; +1 more
    Publisher: Nature Publishing Group
    Country: Spain
    Project: EC | TOPOmics (647359)

    The ATM kinase is a master regulator of the DNA damage response to double-strand breaks (DSBs) and a well-established tumour suppressor whose loss is the cause of the neurodegenerative and cancer-prone syndrome Ataxia-Telangiectasia (A-T). A-T patients and Atm−/− mouse ...

  • Open Access
    Authors: 
    Marta Moreno-Oñate; Andrés Herrero-Ruiz; Mario García-Domínguez; Felipe Cortés-Ledesma; José F. Ruiz;
    Publisher: Elsevier BV
    Country: Spain

    Cellular DNA is under constant attack by a wide variety of agents, both endogenous and exogenous. To counteract DNA damage, human cells have a large collection of DNA repair factors. Among them, DNA polymerase lambda (Polλ) stands out for its versatility, as it particip...

  • Publication . Article . Other literature type . 2017
    Open Access
    Authors: 
    Matthew J. Schellenberg; Jenna Ariel Lieberman; Andrés Herrero-Ruiz; Logan R. Butler; Jason Williams; Ana M. Muñoz-Cabello; Geoffrey A. Mueller; Robert E. London; Felipe Cortés-Ledesma; R. Scott Williams;
    Country: Spain
    Project: EC | TOPOmics (647359), EC | MARCI (332402)

    Topoisomerase 2 (TOP2) DNA transactions proceed via formation of the TOP2 cleavage complex (TOP2cc), a covalent enzyme-DNA reaction intermediate that is vulnerable to trapping by potent anticancer TOP2 drugs. How genotoxic TOP2 DNA-protein cross-links are resolved is un...

  • Open Access English
    Authors: 
    Md. Rasel Al Mahmud; Kenichiro Ishii; Cristina Bernal-Lozano; Irene Delgado-Sainz; Masakazu Toi; Shusuke Akamatsu; Manabu Fukumoto; Masatoshi Watanabe; Shunichi Takeda; Felipe Cortés-Ledesma; +1 more
    Publisher: Wiley-VCH
    Country: Spain

    Androgens stimulate the proliferation of epithelial cells in the prostate by activating topoisomerase 2 (TOP2) and regulating the transcription of target genes. TOP2 resolves the entanglement of genomic DNA by transiently generating double‐strand breaks (DSBs), where TO...

  • Open Access
    Authors: 
    Guillermo Sastre-Moreno; John M. Pryor; Marta Moreno-Oñate; Andrés Herrero-Ruiz; Felipe Cortés-Ledesma; Luis Blanco; Dale A. Ramsden; José F. Ruiz;
    Publisher: Elsevier BV
    Country: Spain

    DNA double strand breaks (DSBs) trigger a variety of cellular signaling processes, collectively termed the DNA-damage response (DDR), that are primarily regulated by protein kinase ataxia-telangiectasia mutated (ATM). Among DDR activated processes, the repair of DSBs by...

  • Open Access
    Authors: 
    Weijun Feng; Daisuke Kawauchi; Huiqin Körkel-Qu; Huan Deng; Elisabeth Serger; Laura Sieber; Jenna Ariel Lieberman; Silvia Jimeno-González; Sander Lambo; Bola S. Hanna; +16 more
    Publisher: Springer Science and Business Media LLC
    Country: Spain
    Project: EC | CancerHetero (647055), EC | TOPOmics (647359)

    Mutations in chromatin modifier genes are frequently associated with neurodevelopmental diseases. We herein demonstrate that the chromodomain helicase DNA-binding protein 7 (Chd7), frequently associated with CHARGE syndrome, is indispensable for normal cerebellar develo...