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  • Publication . Article . 2015
    English
    Authors: 
    Krieger, Teresa; Simons, Benjamin;
    Publisher: The Company of Biologists
    Country: United Kingdom

    Recent lineage-tracing studies based on inducible genetic labelling have emphasized a crucial role for stochasticity in the maintenance and regeneration of cycling adult tissues. These studies have revealed that stem cells are frequently lost through differentiation and...

  • Open Access
    Authors: 
    Hakes, Anna; Brand, Andrea;
    Publisher: Elsevier BV
    Country: United Kingdom

    Determining the premalignant lesions that develop into malignant tumours remains a daunting task. Brain tumours are frequently characterised by a block in differentiation, implying that normal developmental pathways become hijacked during tumourigenesis. However, the he...

  • Publication . Article . 2016 . Embargo End Date: 31 Oct 2016
    English
    Authors: 
    Forment, Josep; Herzog, Mareike; Coates, Julia; Konopka, T; Gapp, BV; Nijman, SM; Adams, DJ; Keane, TM; Jackson, Stephen;
    Publisher: Apollo - University of Cambridge Repository
    Country: United Kingdom

    Research in the S.P.J. laboratory is funded by Cancer Research UK (CRUK; programme grant C6/A11224), the European Research Council and the European Community Seventh Framework Programme (grant agreement no. HEALTH-F2-2010-259893; DDResponse). Core funding is provided by...

  • Authors: 
    Schmidt, Christine K.; Galanty, Yaron; Sczaniecka-Clift, Matylda; Coates, Julia; Jhujh, Satpal; Demir, Mukerrem; Cornwell, Matthew; Beli, Petra; Jackson, Stephen P.;
    Publisher: Apollo - University of Cambridge Repository
    Country: United Kingdom

    Complete set of graphs for gammaH2AX, 53BP1 and ubiquitin (FK2 antibody) foci/cell kinetics in response to ionising radiation (IR)- and mock-treated human U2OS cells treated with siRNAs targeting ubiquitin E2s (screening module 1; refers to Fig. 1). Complete set of DDR ...

  • Publication . Article . 2017 . Embargo End Date: 17 Aug 2017
    Open Access English
    Authors: 
    Hackett, JA; Kobayashi, T; Dietmann, S; Surani, MA; Surani, A;
    Publisher: Apollo - University of Cambridge Repository
    Country: United Kingdom

    Embryonic stem cells (ESC) are characterised by the pluripotent capacity to generate all embryonic lineages. Here we show ESC can occupy a spectrum of distinct transcriptional and epigenetic states in response to varied extrinsic conditions. This spectrum broadly corres...

  • Publication . Article . Other literature type . 2016
    Open Access
    Authors: 
    Paul Bamborough; Chun-wa Chung; Emmanuel Hubert Demont; Rebecca C. Furze; Andrew J. Bannister; Ka Hing Che; Hawa Diallo; Clement Douault; Paola Grandi; Tony Kouzarides; +8 more
    Publisher: Wiley
    Country: United Kingdom

    ATAD2 is a cancer-associated protein whose bromodomain has been described as among the least druggable of that target class. Starting from a potent lead, permeability and selectivity were improved through a dual approach: 1) using CF2 as a sulfone bio-isostere to exploi...

  • Publication . Article . 2017
    Open Access
    Authors: 
    Otsuki, Leo; Brand, Andrea;
    Publisher: Elsevier BV
    Country: United Kingdom

    Neural stem cells (NSCs) are multipotent, self-renewing progenitors that generate progeny that differentiate into neurons and glia. NSCs in the adult mammalian brain are generally quiescent. Environmental stimuli such as learning or exercise can activate quiescent NSCs,...

  • Open Access English
    Authors: 
    Marshall, Owen J.; Brand, Andrea H.;
    Publisher: Oxford University Press (OUP)
    Country: United Kingdom
    Project: WT | Regulation of self-renewa... (092545), WT | Core support for the Well... (092096), UKRI | A genome-wide analysis of... (BB/L00786X/1)

    UNLABELLED: DamID is a powerful technique for identifying regions of the genome bound by a DNA-binding (or DNA-associated) protein. Currently, no method exists for automatically processing next-generation sequencing DamID (DamID-seq) data, and the use of DamID-seq datas...

  • English
    Authors: 
    Ochi, Takashi; Blackford, Andrew; Coates, Julia; Jhujh, Satpal; Mehmood, Shahid; Tamura, Naoka; Travers, Jon; Wu, Qian; Draviam Sastry, Viji; Robinson, Carol V; +2 more
    Publisher: American Association for the Advancement of Science (AAAS)
    Country: United Kingdom

    XRCC4 and XLF are two structurally related proteins that function in DNA double-strand break (DSB) repair. Here, we identify human PAXX (PAralog of XRCC4 and XLF, also called C9orf142) as a new XRCC4 superfamily member and show that its crystal structure resembles that ...

  • Open Access English
    Authors: 
    Maartens, Aidan; Wellmann, J; Wictome, E; Klapholz, Benjamin; Green, Hannah; Brown, Nicholas;
    Publisher: Apollo - University of Cambridge Repository
    Country: United Kingdom

    Vinculin is a highly conserved protein involved in cell adhesion and mechanotransduction, and both gain and loss of its activity causes defective cell behaviour. Here, we examine how altering vinculin activity perturbs integrin function within the context of $\textit{Dr...