research data . Dataset . 2017

Dynamics Of Individual T Cell Repertoires: From Cord Blood To Centenarians

Genomics Of Adaptive Immunity Laboratory;
Open Access
  • Published: 13 Jul 2017
  • Publisher: Zenodo
The dataset contains processed T-cell receptor repertoire sequencing data from 79 individuals of different sex and age, originally published in [1] and [2]. Note that [1] describes only a subset of samples, while [2] describes the full cohort. The libraries were prepared using a 5'RACE protocol and sequenced on HiSEQ. The libraries incorporate unique molecular identifier (UMI) tags that were mainly used for counting cDNA molecules. Preprocessing was performed using the MIGEC software [3] as follows: all UMI tags represented by a single sequencing read were discarded, the remaining UMI tags were used to assemble cDNA consensus sequences. Note that this procedure ...
free text keywords: t-cell, immune repertoire, sequencing, immunology
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