research data . Dataset . 2017

Transcriptional Decomposition Reveals Active Chromatin Architectures And Cell Specific Regulatory Interactions

Rennie, Sarah; Dalby, Maria; van Duin, Lucas; Andersson, Robin;
Open Access
  • Published: 24 Apr 2017
  • Publisher: Zenodo
Abstract
Summary Resource data across the 76 cell types from FANTOM5 analysed in our paper titled "Transcriptional decomposition reveals active chromatin architectures and cell specific regulatory interactions". Project abstract Gene transcription is influenced by favourable chromosome positioning and chromatin architectures bringing regulatory elements in close proximity. However, it is unclear to what extent transcription is attributable to topological organisation or to gene-specific regulatory programs. Here, we develop a strategy to transcriptionally decompose expression data into two main components reflecting the positional relationship of neighbouring transcripti...
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